| Name |
Macular degeneration (macula_degen) |
| Category |
Eye |
| Sex |
|
| Adult |
Yes |
| UUID |
57aeb75c-924f-48dd-b997-df9436f2984f |
| Definition |
A retinal degeneration characterized by gradual deterioration of light-sensing cells in the tissues at the back of the eye and has_symptom vision loss. |
Ontologies
Key Summary Statistics
Cases from any source
| Total |
13203 |
| Female (%) |
7837 (59%) |
| Male (%) |
5366 (41%) |
Year first recorded
Cases linked in all UK Biobank sources
Cross-source concordance
Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.
Incidence & prevalence
Baseline prevalence stratified by sex
| Female |
123.06 (115.64,130.48) |
| Male |
111.99 (104.28,119.71) |
Incidence stratified by sex
| Female |
11.38 (10.49,12.26) |
| Male |
9.43 (8.55,10.3) |
Incidence stratified by age
| Ages 40-44 |
1.61 (0.82,2.4) |
| Ages 45-49 |
2.76 (1.87,3.65) |
| Ages 50-54 |
2.8 (1.97,3.63) |
| Ages 55-59 |
7.51 (6.28,8.74) |
| Ages 60-64 |
14.47 (12.99,15.94) |
| Ages 65-69 |
24.34 (22.14,26.54) |
Period prevalence
Methods
Comparison with general population
Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)
| Population |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| UK Biobank |
20 (16,25) |
42 (37,47) |
150 (143,159) |
| CALIBER |
18 (17,19) |
51 (49,53) |
164 (160,168) |
Stratified by age and Townsend deprivation status
| Deprivation status |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| Least deprived |
22(13,36) |
42(32,55) |
148(131,166) |
| Low |
18(10,31) |
33(24,45) |
119(104,136) |
| Medium |
15(7,27) |
43(32,56) |
149(132,167) |
| High |
26(16,39) |
43(33,56) |
165(147,186) |
| Most deprived |
18(11,28) |
45(35,58) |
178(158,200) |
Stratified by age and country
| Country |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| England |
18(14,23) |
36(31,42) |
140(132,149) |
| Scotland |
38(22,60) |
57(42,75) |
207(180,236) |
| Wales |
10(2,31) |
70(49,96) |
175(145,209) |
Risk factors analysis
‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.
Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method
N=153508, Events=407
| Factor |
Level |
Hazard Ratio |
P value |
| BMI |
overweight |
0.96 (0.75, 1.22) |
0.716 |
| BMI |
obese |
1.36 (1.06, 1.76) |
0.0167 |
| BMI |
underweight |
0 (0, Inf) |
0.986 |
| smoking |
previous |
1.37 (1.1, 1.7) |
0.00438 |
| smoking |
current |
2.14 (1.6, 2.85) |
2.26e-07 |
| hypertension |
yes |
1.88 (1.53, 2.31) |
1.47e-09 |
Definition
| UK Biobank field id |
Description |
Code |
Value |
| 20002 |
Non-cancer illness code, self-reported |
1528 |
macular degeneration |
| 41202 |
Diagnoses - main ICD10 |
H35.3 |
Degeneration of macula and posterior pole |
| 41204 |
Diagnoses - secondary ICD10 |
H35.3 |
Degeneration of macula and posterior pole |
| 40001 |
Underlying (primary) cause of death: ICD10 |
H35.3 |
Degeneration of macula and posterior pole |
| 40002 |
Contributory (secondary) causes of death: ICD10 |
H35.3 |
Degeneration of macula and posterior pole |
| 42040 |
GP clinical event records |
2BBH.00 |
Retinal drusen |
| 42040 |
GP clinical event records |
F424200 |
Retinal pigment epithelium serous detachment |
| 42040 |
GP clinical event records |
F424300 |
Retinal pigment epithelium haemorrhagic detachment |
| 42040 |
GP clinical event records |
F424400 |
Retinal pigment epithelial detachment |
| 42040 |
GP clinical event records |
F425000 |
Unspecified senile macular degeneration |
| 42040 |
GP clinical event records |
F425100 |
Dry senile macular degeneration |
| 42040 |
GP clinical event records |
F425200 |
Wet senile macular degeneration |
| 42040 |
GP clinical event records |
F425211 |
Kuhnt - Junius degeneration |
| 42040 |
GP clinical event records |
F425700 |
Drusen |
| 42040 |
GP clinical event records |
F425.00 |
Degeneration of macula and posterior pole |
| 42040 |
GP clinical event records |
F425.11 |
Senile macular degeneration |
| 42040 |
GP clinical event records |
F425z00 |
Degeneration of macula or posterior pole NOS |
| 42040 |
GP clinical event records |
X00eG |
Retinal pigment epithelial detachment |
| 42040 |
GP clinical event records |
XE15x |
Degeneration of macula and posterior pole |
| 42040 |
GP clinical event records |
X75mo |
Retinal drusen |
| 5912 |
Which eye(s) affected by macular degeneration |
1 |
Right |
| 5912 |
Which eye(s) affected by macular degeneration |
2 |
Left |
| 5912 |
Which eye(s) affected by macular degeneration |
3 |
Right |
| 6148 |
Eye problems/disorders |
5 |
Macular degeneration |