Male infertility

Metadata

Name	Male infertility (male_infertility)
Category	Genitourinary
Sex
Adult	Yes
UUID	fda24d9d-619f-41a3-acf7-9be064fdad9a
Definition	The inability of the male to effect fertilization of an ovum after a specified period of unprotected intercourse.

Ontologies

Disease Ontology (DOID)	DOID_12336
GWAS Catalogue	EFO_0004248
MeSH	D007248
SNOMED-CT	2904007
FinnGen	N14_MALEINFERT

Key Summary Statistics

Cases from any source

Total	716
Female (%)	0 (0%)
Male (%)	716 (100%)

Year first recorded

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Incidence & prevalence

Baseline prevalence stratified by sex

Female	0.0 (0.0,0.0)
Male	57.12 (51.59,62.64)

Incidence stratified by sex

Female	0.0 (0.0,0.0)
Male	0.53 (0.32,0.74)

Incidence stratified by age

Ages 40-44	1.41 (0.67,2.15)
Ages 45-49	0.52 (0.13,0.91)
Ages 50-54	0.19 (-0.03,0.41)
Ages 55-59	0.05 (-0.05,0.15)
Ages 60-64	0.0 (0.0,0.0)
Ages 65-69	0.0 (0.0,0.0)

Period prevalence

Methods

Comparison with general population

Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)

Population	Ages 40-49	Ages 50-59	Ages 60-69
UK Biobank	54 (47,62)	36 (31,41)	19 (16,22)
CALIBER	136 (132,140)	85 (81,88)	44 (41,47)

Stratified by age and Townsend deprivation status

Deprivation status	Ages 40-49	Ages 50-59	Ages 60-69
Least deprived	67(49,90)	38(27,51)	29(21,37)
Low	59(41,81)	38(27,51)	13(8,20)
Medium	41(27,60)	38(28,51)	18(13,26)
High	63(47,83)	35(25,48)	18(12,26)
Most deprived	44(32,59)	30(21,41)	15(9,22)

Stratified by age and country

Country	Ages 40-49	Ages 50-59	Ages 60-69
England	54(46,62)	38(33,44)	19(16,23)
Scotland	60(39,88)	35(23,50)	26(17,39)
Wales	52(28,87)	15(6,31)	6(2,16)

Definition

UK Biobank field id	Description	Code	Value
20002	Non-cancer illness code, self-reported	1404	male infertility
41202	Diagnoses - main ICD10	N46	Male infertility
41204	Diagnoses - secondary ICD10	N46	Male infertility
40001	Underlying (primary) cause of death: ICD10	N46	Male infertility
40002	Contributory (secondary) causes of death: ICD10	N46	Male infertility
42040	GP clinical event records	4914.00	Semen exam.: low fertility
42040	GP clinical event records	4915.00	Semen exam.:very low fertility
42040	GP clinical event records	4916.00	Semen exam.: infertile
42040	GP clinical event records	4917.00	Semen exam: abnormal
42040	GP clinical event records	K260.00	Azoospermia
42040	GP clinical event records	K260.11	Young’s syndrome
42040	GP clinical event records	K261000	Oligoasthenozoospermia
42040	GP clinical event records	K261.00	Oligospermia
42040	GP clinical event records	K262.00	Aspermia
42040	GP clinical event records	K26..00	Male infertility
42040	GP clinical event records	K26y200	Infertility due to efferent duct obstruction
42040	GP clinical event records	K26y300	Infertility due to radiation
42040	GP clinical event records	K26y400	Infertility in systemic disease
42040	GP clinical event records	K26y.00	Infertility due to extratesticular cause
42040	GP clinical event records	K26yz00	Infertility due to extratesticular cause NOS
42040	GP clinical event records	K26z.00	Male infertility NOS
42040	GP clinical event records	K5B1000	Primary pituitary - hypothalamic infertility
42040	GP clinical event records	K5B1100	Secondary pituitary - hypothalamic infertility
42040	GP clinical event records	K5B6.00	Female infertility associated with male factors
42040	GP clinical event records	K5By000	Primary infertility unspecified
42040	GP clinical event records	K5By100	Secondary infertility unspecified
42040	GP clinical event records	K5Byz11	Subfertility
42040	GP clinical event records	XaXbT	Oligoasthenozoospermia
42040	GP clinical event records	XE0ey	Other female infertility NOS
42040	GP clinical event records	XE0eA	Azoospermia
42040	GP clinical event records	X409B	Female infertility associated with male factors
42040	GP clinical event records	XaXUx	Aspermia