Myelodysplastic syndromes

Metadata

Name	Myelodysplastic syndromes (MDS)
Category	Cancers
Sex
Adult	Yes
UUID	d1d622aa-5b48-4749-9f05-521e7f6e04e3
Definition	Clonal hematopoietic stem cell disorders characterized by dysplasia in one or more hematopoietic cell lineages.

Ontologies

Disease Ontology (DOID)	DOID_0050908
GWAS Catalogue	EFO_0000198
MeSH	D009190
SNOMED-CT	128623006

Key Summary Statistics

Cases from any source

Total	810
Female (%)	314 (39%)
Male (%)	496 (61%)

Year first recorded

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Incidence & prevalence

Baseline prevalence stratified by sex

Female	1.89 (0.96,2.81)
Male	2.66 (1.46,3.86)

Incidence stratified by sex

Female	0.42 (0.25,0.59)
Male	1.14 (0.83,1.44)

Incidence stratified by age

Ages 40-44	0.3 (-0.04,0.64)
Ages 45-49	0.22 (-0.03,0.47)
Ages 50-54	0.38 (0.08,0.68)
Ages 55-59	0.88 (0.46,1.3)
Ages 60-64	0.54 (0.26,0.82)
Ages 65-69	1.76 (1.18,2.34)

Period prevalence

Methods

Comparison with general population

Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)

Population	Ages 40-49	Ages 50-59	Ages 60-69
UK Biobank	3 (1,5)	6 (4,9)	9 (7,11)
CALIBER	2 (2,3)	5 (5,6)	15 (13,16)

Stratified by age and Townsend deprivation status

Deprivation status	Ages 40-49	Ages 50-59	Ages 60-69
Least deprived	3(0,10)	3(1,8)	7(4,12)
Low	3(0,9)	10(5,17)	8(4,13)
Medium	3(0,10)	7(3,13)	9(5,15)
High	3(1,10)	6(3,12)	10(6,16)
Most deprived	2(0,7)	6(2,11)	9(5,16)

Stratified by age and country

Country	Ages 40-49	Ages 50-59	Ages 60-69
England	3(2,6)	6(4,9)	8(6,11)
Scotland	0(NaN,NaN)	6(2,14)	9(4,16)
Wales	0(NaN,NaN)	5(1,15)	12(5,23)

Definition

UK Biobank field id	Description	Code	Value
20001	Cancer code, self-reported	1051	myelofibrosis or myelodysplasia
41202	Diagnoses - main ICD10	D46	Myelodysplastic syndromes
41204	Diagnoses - secondary ICD10	D46	Myelodysplastic syndromes
40001	Underlying (primary) cause of death: ICD10	D46	Myelodysplastic syndromes
40002	Contributory (secondary) causes of death: ICD10	D46	Myelodysplastic syndromes
42040	GP clinical event records	7Q09700	Myelodysplastic syndrome drugs Band 1
42040	GP clinical event records	B937000	Refractory anaemia without sideroblasts, so stated
42040	GP clinical event records	B937100	Refractory anaemia with sideroblasts
42040	GP clinical event records	B937200	Refractory anaemia with excess of blasts
42040	GP clinical event records	B937300	Refractory anaemia with excess of blasts with transformation
42040	GP clinical event records	B937600	Refractory anaemia without ring sideroblasts
42040	GP clinical event records	B937700	Refractory anaemia with ring sideroblasts
42040	GP clinical event records	B937800	Refractory anaemia with multilineage dysplasia
42040	GP clinical event records	B937900	5Q minus syndrome
42040	GP clinical event records	B937911	Myelodysplastic syndrome isolated del(5q) chromosomal abnorm
42040	GP clinical event records	B937.14	Myelodysplasia
42040	GP clinical event records	B937W00	Myelodysplastic syndrome, unspecified
42040	GP clinical event records	B937W11	Myelodysplasia
42040	GP clinical event records	B937X00	Refractory anaemia, unspecified
42040	GP clinical event records	BBmA.00	[M] Refractory anaemia with sideroblasts
42040	GP clinical event records	BBmB.00	[M]Refractory anaemia+excess of blasts with transformation
42040	GP clinical event records	BBmL.00	[M] Refractory anaemia with excess of blasts
42040	GP clinical event records	BBv..00	[M]Myelodysplastic syndrome
42040	GP clinical event records	ByuHD00	[X]Myelodysplastic syndrome, unspecified
42040	GP clinical event records	D213.00	Refractory Anaemia
42040	GP clinical event records	XaBC5	[M] Refractory anaemia with excess of blasts
42040	GP clinical event records	XaYv2	Refractory anaemia with multilineage dysplasia
42040	GP clinical event records	Xa0Sh	5Q minus syndrome
42040	GP clinical event records	XE1wQ	Neoplasm of uncertain behaviour of other lymphatic and haematopoietic tissue
42040	GP clinical event records	XaXJF	Myelodysplastic syndrome drugs Band 1
40006	Type of cancer: ICD10	D46	Myelodysplastic syndromes