| Name |
Meniere disease (meniere) |
| Category |
Ear |
| Sex |
|
| Adult |
Yes |
| UUID |
67dc1fe3-3091-4215-ac9b-9a04f080f5ab |
| Definition |
A disease of the inner ear (LABYRINTH) that is characterized by fluctuating SENSORINEURAL HEARING LOSS; TINNITUS; episodic VERTIGO; and aural fullness. |
Ontologies
Key Summary Statistics
Cases from any source
| Total |
3166 |
| Female (%) |
2021 (64%) |
| Male (%) |
1145 (36%) |
Year first recorded
Cases linked in all UK Biobank sources
Cross-source concordance
Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.
Incidence & prevalence
Baseline prevalence stratified by sex
| Female |
72.61 (66.9,78.33) |
| Male |
47.46 (42.42,52.5) |
Incidence stratified by sex
| Female |
2.28 (1.89,2.68) |
| Male |
1.44 (1.1,1.78) |
Incidence stratified by age
| Ages 40-44 |
1.21 (0.52,1.89) |
| Ages 45-49 |
1.79 (1.07,2.5) |
| Ages 50-54 |
2.1 (1.38,2.82) |
| Ages 55-59 |
2.04 (1.4,2.68) |
| Ages 60-64 |
2.05 (1.5,2.6) |
| Ages 65-69 |
1.82 (1.23,2.42) |
Period prevalence
Methods
Comparison with general population
Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)
| Population |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| UK Biobank |
28 (24,34) |
54 (49,60) |
82 (77,89) |
| CALIBER |
22 (21,23) |
45 (43,47) |
76 (73,78) |
Stratified by age and Townsend deprivation status
| Deprivation status |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| Least deprived |
28(17,43) |
52(41,65) |
77(65,90) |
| Low |
30(19,45) |
57(45,71) |
80(68,94) |
| Medium |
26(16,40) |
56(45,70) |
88(75,102) |
| High |
26(17,39) |
49(38,62) |
83(70,97) |
| Most deprived |
31(22,44) |
56(44,70) |
85(71,100) |
Stratified by age and country
| Country |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| England |
23(19,29) |
50(44,56) |
72(66,78) |
| Scotland |
42(26,64) |
40(28,55) |
83(66,102) |
| Wales |
62(38,97) |
121(94,154) |
193(161,228) |
Risk factors analysis
‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.
Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method
N=153646, Events=402
| Factor |
Level |
Hazard Ratio |
P value |
| BMI |
overweight |
1.07 (0.82, 1.39) |
0.637 |
| BMI |
obese |
2.13 (1.65, 2.77) |
1.06e-08 |
| BMI |
underweight |
0 (0, Inf) |
0.986 |
| smoking |
previous |
1.48 (1.19, 1.85) |
0.000498 |
| smoking |
current |
2.47 (1.87, 3.26) |
1.43e-10 |
| hypertension |
yes |
2.21 (1.8, 2.72) |
5.76e-14 |
Definition
| UK Biobank field id |
Description |
Code |
Value |
| 20002 |
Non-cancer illness code, self-reported |
1421 |
meniere’s disease |
| 41202 |
Diagnoses - main ICD10 |
H81.0 |
Meniere’s disease |
| 41204 |
Diagnoses - secondary ICD10 |
H81.0 |
Meniere’s disease |
| 40001 |
Underlying (primary) cause of death: ICD10 |
H81.0 |
Meniere’s disease |
| 40002 |
Contributory (secondary) causes of death: ICD10 |
H81.0 |
Meniere’s disease |
| 42040 |
GP clinical event records |
1491.11 |
H/O: Meniere’s disease |
| 42040 |
GP clinical event records |
F560000 |
Unspecified Meniere’s disease |
| 42040 |
GP clinical event records |
F560100 |
Active cochleovestibular Meniere’s disease |
| 42040 |
GP clinical event records |
F560200 |
Active cochlear Meniere’s disease |
| 42040 |
GP clinical event records |
F560300 |
Active vestibular Meniere’s disease |
| 42040 |
GP clinical event records |
F560400 |
Inactive Meniere’s disease |
| 42040 |
GP clinical event records |
F560.00 |
Meniere’s disease |
| 42040 |
GP clinical event records |
F560.11 |
Endolymphatic hydrops |
| 42040 |
GP clinical event records |
F560.12 |
Lermoyez’s syndrome |
| 42040 |
GP clinical event records |
F560z00 |
Meniere’s disease NOS |