Metadata

Name Meningitis (meningitis)
Category Infections
Sex
Adult Yes
UUID 26187c29-7b47-4cd2-90a0-ed4c825fab0d
Definition A central nervous system disease that is characterized by an inflammation of the pia-arachnoid meninges. It can be caused by growth of bacteria, fungi, or parasites within the subarachnoid space or by the growth of bacteria or viruses within the meningeal or ependymal cells.

Ontologies

Disease Ontology (DOID) DOID_9471
GWAS Catalogue EFO_0000584
MeSH D008581
SNOMED-CT 7180009
FinnGen MENINGITIS

Key Summary Statistics

Cases from any source

Total 2449
Female (%) 1285 (52%)
Male (%) 1164 (48%)

Year first recorded

meningitis year of first event

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Cross-sourced meningitis cases

Incidence & prevalence

Sex and age-stratified incidence and prevalence of meningitis

Baseline prevalence stratified by sex

Female 37.13 (33.04,41.22)
Male 45.64 (40.69,50.58)

Incidence stratified by sex

Female 0.37 (0.21,0.53)
Male 0.4 (0.22,0.58)

Incidence stratified by age

Ages 40-44 0.4 (0.01,0.8)
Ages 45-49 0.45 (0.09,0.8)
Ages 50-54 0.19 (-0.03,0.41)
Ages 55-59 0.21 (0.0,0.41)
Ages 60-64 0.5 (0.23,0.77)
Ages 65-69 0.5 (0.19,0.82)

Period prevalence

Methods

Comparison with general population

Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)

CALIBER and UKB meningitis prevalence comparison for multiple age groups

Population Ages 40-49 Ages 50-59 Ages 60-69
UK Biobank 12 (9,16) 6 (5,9) 6 (5,8)
CALIBER 12 (11,13) 8 (7,9) 6 (5,7)

Stratified by age and Townsend deprivation status

Deprivation status Ages 40-49 Ages 50-59 Ages 60-69
Least deprived 14(7,26) 9(4,16) 7(4,12)
Low 11(5,21) 3(1,8) 7(4,12)
Medium 16(8,27) 5(2,11) 6(3,10)
High 10(5,20) 8(4,15) 7(3,12)
Most deprived 12(7,21) 6(2,11) 4(1,8)

Stratified by age and country

Country Ages 40-49 Ages 50-59 Ages 60-69
England 15(11,19) 6(4,8) 7(5,9)
Scotland 2(0,10) 8(3,16) 5(2,12)
Wales 6(1,22) 8(2,20) 1(0,8)

Definition

UK Biobank field id Description Code Value
20002 Non-cancer illness code, self-reported 1247 meningitis
41202 Diagnoses - main ICD10 A17.0 Tuberculous meningitis
41202 Diagnoses - main ICD10 A17.1 Meningeal tuberculoma
41202 Diagnoses - main ICD10 A20.3 Plague meningitis
41202 Diagnoses - main ICD10 A32.1 Listerial meningitis and meningoencephalitis
41202 Diagnoses - main ICD10 A39.0 Meningococcal meningitis
41202 Diagnoses - main ICD10 A87 Viral meningitis
41202 Diagnoses - main ICD10 B00.3 Herpesviral meningitis
41202 Diagnoses - main ICD10 B01.0 Varicella meningitis
41202 Diagnoses - main ICD10 B02.1 Zoster meningitis
41202 Diagnoses - main ICD10 B05.1 Measles complicated by meningitis
41202 Diagnoses - main ICD10 B26.1 Mumps meningitis
41202 Diagnoses - main ICD10 B37.5 Candidal meningitis
41202 Diagnoses - main ICD10 B38.4 Coccidioidomycosis meningitis
41202 Diagnoses - main ICD10 G00 Bacterial meningitis, not elsewhere classified
41202 Diagnoses - main ICD10 G01 Meningitis in bacterial diseases classified elsewhere
41202 Diagnoses - main ICD10 G02.0 Meningitis in viral diseases classified elsewhere
41202 Diagnoses - main ICD10 G02.1 Meningitis in mycoses
41202 Diagnoses - main ICD10 G02.8 Meningitis in other specified infectious and parasitic diseases classified elsewhere
41204 Diagnoses - secondary ICD10 A17.0 Tuberculous meningitis
41204 Diagnoses - secondary ICD10 A17.1 Meningeal tuberculoma
41204 Diagnoses - secondary ICD10 A20.3 Plague meningitis
41204 Diagnoses - secondary ICD10 A32.1 Listerial meningitis and meningoencephalitis
41204 Diagnoses - secondary ICD10 A39.0 Meningococcal meningitis
41204 Diagnoses - secondary ICD10 A87 Viral meningitis
41204 Diagnoses - secondary ICD10 B00.3 Herpesviral meningitis
41204 Diagnoses - secondary ICD10 B01.0 Varicella meningitis
41204 Diagnoses - secondary ICD10 B02.1 Zoster meningitis
41204 Diagnoses - secondary ICD10 B05.1 Measles complicated by meningitis
41204 Diagnoses - secondary ICD10 B26.1 Mumps meningitis
41204 Diagnoses - secondary ICD10 B37.5 Candidal meningitis
41204 Diagnoses - secondary ICD10 B38.4 Coccidioidomycosis meningitis
41204 Diagnoses - secondary ICD10 G00 Bacterial meningitis, not elsewhere classified
41204 Diagnoses - secondary ICD10 G01 Meningitis in bacterial diseases classified elsewhere
41204 Diagnoses - secondary ICD10 G02.0 Meningitis in viral diseases classified elsewhere
41204 Diagnoses - secondary ICD10 G02.1 Meningitis in mycoses
41204 Diagnoses - secondary ICD10 G02.8 Meningitis in other specified infectious and parasitic diseases classified elsewhere
40001 Underlying (primary) cause of death: ICD10 A17.0 Tuberculous meningitis
40001 Underlying (primary) cause of death: ICD10 A17.1 Meningeal tuberculoma
40001 Underlying (primary) cause of death: ICD10 A20.3 Plague meningitis
40001 Underlying (primary) cause of death: ICD10 A32.1 Listerial meningitis and meningoencephalitis
40001 Underlying (primary) cause of death: ICD10 A39.0 Meningococcal meningitis
40001 Underlying (primary) cause of death: ICD10 A87 Viral meningitis
40001 Underlying (primary) cause of death: ICD10 B00.3 Herpesviral meningitis
40001 Underlying (primary) cause of death: ICD10 B01.0 Varicella meningitis
40001 Underlying (primary) cause of death: ICD10 B02.1 Zoster meningitis
40001 Underlying (primary) cause of death: ICD10 B05.1 Measles complicated by meningitis
40001 Underlying (primary) cause of death: ICD10 B26.1 Mumps meningitis
40001 Underlying (primary) cause of death: ICD10 B37.5 Candidal meningitis
40001 Underlying (primary) cause of death: ICD10 B38.4 Coccidioidomycosis meningitis
40001 Underlying (primary) cause of death: ICD10 G00 Bacterial meningitis, not elsewhere classified
40001 Underlying (primary) cause of death: ICD10 G01 Meningitis in bacterial diseases classified elsewhere
40001 Underlying (primary) cause of death: ICD10 G02.0 Meningitis in viral diseases classified elsewhere
40001 Underlying (primary) cause of death: ICD10 G02.1 Meningitis in mycoses
40001 Underlying (primary) cause of death: ICD10 G02.8 Meningitis in other specified infectious and parasitic diseases classified elsewhere
40002 Contributory (secondary) causes of death: ICD10 A17.0 Tuberculous meningitis
40002 Contributory (secondary) causes of death: ICD10 A17.1 Meningeal tuberculoma
40002 Contributory (secondary) causes of death: ICD10 A20.3 Plague meningitis
40002 Contributory (secondary) causes of death: ICD10 A32.1 Listerial meningitis and meningoencephalitis
40002 Contributory (secondary) causes of death: ICD10 A39.0 Meningococcal meningitis
40002 Contributory (secondary) causes of death: ICD10 A87 Viral meningitis
40002 Contributory (secondary) causes of death: ICD10 B00.3 Herpesviral meningitis
40002 Contributory (secondary) causes of death: ICD10 B01.0 Varicella meningitis
40002 Contributory (secondary) causes of death: ICD10 B02.1 Zoster meningitis
40002 Contributory (secondary) causes of death: ICD10 B05.1 Measles complicated by meningitis
40002 Contributory (secondary) causes of death: ICD10 B26.1 Mumps meningitis
40002 Contributory (secondary) causes of death: ICD10 B37.5 Candidal meningitis
40002 Contributory (secondary) causes of death: ICD10 B38.4 Coccidioidomycosis meningitis
40002 Contributory (secondary) causes of death: ICD10 G00 Bacterial meningitis, not elsewhere classified
40002 Contributory (secondary) causes of death: ICD10 G01 Meningitis in bacterial diseases classified elsewhere
40002 Contributory (secondary) causes of death: ICD10 G02.0 Meningitis in viral diseases classified elsewhere
40002 Contributory (secondary) causes of death: ICD10 G02.1 Meningitis in mycoses
40002 Contributory (secondary) causes of death: ICD10 G02.8 Meningitis in other specified infectious and parasitic diseases classified elsewhere