Menorrhagia and polymenorrhoea

Metadata

Name	Menorrhagia and polymenorrhoea (menorrhagia)
Category	Genitourinary
Sex
Adult	Yes
UUID	37b34e03-641b-4209-bb17-c1f6be2d3601
Definition	Menorrhagia is the medical term for menstrual periods with abnormally heavy or prolonged bleeding.

Ontologies

Disease Ontology (DOID)	DOID_756
GWAS Catalogue	HP_0000132
MeSH	D008595
SNOMED-CT	386692008
FinnGen	N14_MENORRHAGIA

Key Summary Statistics

Cases from any source

Total	29009
Female (%)	29009 (100%)
Male (%)	0 (0%)

Year first recorded

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Incidence & prevalence

Baseline prevalence stratified by sex

Female	1358.18 (1335.13,1381.24)
Male	0.0 (0.0,0.0)

Incidence stratified by sex

Female	31.33 (29.76,32.91)
Male	0.0 (0.0,0.0)

Incidence stratified by age

Ages 40-44	73.4 (67.8,79.0)
Ages 45-49	53.4 (49.25,57.55)
Ages 50-54	14.61 (12.61,16.62)
Ages 55-59	0.97 (0.51,1.43)
Ages 60-64	0.08 (-0.03,0.2)
Ages 65-69	0.1 (-0.04,0.25)

Period prevalence

Methods

Comparison with general population

Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)

Population	Ages 40-49	Ages 50-59	Ages 60-69
UK Biobank	1177 (1145,1209)	972 (950,995)	490 (476,504)
CALIBER	2788 (2768,	2654 (2632,	1410 (1393,

Stratified by age and Townsend deprivation status

Deprivation status	Ages 40-49	Ages 50-59	Ages 60-69
Least deprived	1132(1060,1209)	980(930,1031)	526(496,559)
Low	1175(1101,1253)	974(925,1026)	475(446,505)
Medium	1136(1066,1210)	999(949,1050)	499(469,530)
High	1172(1106,1241)	953(905,1003)	470(440,502)
Most deprived	1250(1184,1318)	954(905,1005)	476(443,510)

Stratified by age and country

Country	Ages 40-49	Ages 50-59	Ages 60-69
England	1243(1207,1280)	1003(978,1029)	498(482,514)
Scotland	624(562,692)	680(630,733)	448(411,488)
Wales	1411(1286,1545)	1152(1067,1241)	472(423,524)

Risk factors analysis

‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.

Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method

N=153321, Events=259

Factor	Level	Hazard Ratio	P value
BMI	overweight	1.47 (1.07, 2.01)	0.0165
BMI	obese	2.46 (1.81, 3.35)	1.19e-08
BMI	underweight	0 (0, Inf)	0.998
smoking	previous	1.06 (0.81, 1.39)	0.676
smoking	current	0.75 (0.46, 1.22)	0.25
hypertension	yes	0.83 (0.58, 1.19)	0.31

Definition

UK Biobank field id	Description	Code	Value
20002	Non-cancer illness code, self-reported	1556	menorrhagia (unknown cause)
41202	Diagnoses - main ICD10	N92.0	Excessive and frequent menstruation with regular cycle
41202	Diagnoses - main ICD10	N92.1	Excessive and frequent menstruation with irregular cycle
41202	Diagnoses - main ICD10	N92.2	Excessive menstruation at puberty
41202	Diagnoses - main ICD10	N92.4	Excessive bleeding in the premenopausal period
41204	Diagnoses - secondary ICD10	N92.0	Excessive and frequent menstruation with regular cycle
41204	Diagnoses - secondary ICD10	N92.1	Excessive and frequent menstruation with irregular cycle
41204	Diagnoses - secondary ICD10	N92.2	Excessive menstruation at puberty
41204	Diagnoses - secondary ICD10	N92.4	Excessive bleeding in the premenopausal period
40001	Underlying (primary) cause of death: ICD10	N92.0	Excessive and frequent menstruation with regular cycle
40001	Underlying (primary) cause of death: ICD10	N92.1	Excessive and frequent menstruation with irregular cycle
40001	Underlying (primary) cause of death: ICD10	N92.2	Excessive menstruation at puberty
40001	Underlying (primary) cause of death: ICD10	N92.4	Excessive bleeding in the premenopausal period
40002	Contributory (secondary) causes of death: ICD10	N92.0	Excessive and frequent menstruation with regular cycle
40002	Contributory (secondary) causes of death: ICD10	N92.1	Excessive and frequent menstruation with irregular cycle
40002	Contributory (secondary) causes of death: ICD10	N92.2	Excessive menstruation at puberty
40002	Contributory (secondary) causes of death: ICD10	N92.4	Excessive bleeding in the premenopausal period
42040	GP clinical event records	151G.00	Length of cycle decreasing
42040	GP clinical event records	1572.00	H/O: polymenorrhoea
42040	GP clinical event records	1573.00	H/O: menorrhagia
42040	GP clinical event records	1573.11	H/O: heavy periods
42040	GP clinical event records	K592000	Menorrhagia
42040	GP clinical event records	K592011	Heavy periods
42040	GP clinical event records	K592012	Heavy menstrual bleeding
42040	GP clinical event records	K592100	Polymenorrhoea
42040	GP clinical event records	K592111	Epimenorrhoea
42040	GP clinical event records	K592.00	Excessive or frequent menstruation
42040	GP clinical event records	K592.11	Frequent menses
42040	GP clinical event records	K592.12	Hypermenorrhoea
42040	GP clinical event records	K592z00	Excessive or frequent menstruation NOS
42040	GP clinical event records	K593.11	Pubertal bleeding and menorrhagia
42040	GP clinical event records	K5A0.00	Premenopausal menorrhagia
42040	GP clinical event records	K5A0.11	Climacteric menorrhagia
42040	GP clinical event records	K5A6.00	Perimenopausal menorrhagia
42040	GP clinical event records	XE0ep	Puberty bleeding
42040	GP clinical event records	Xa9CP	Perimenopausal menorrhagia
42040	GP clinical event records	XE0ew	Premenopausal menorrhagia