| Name |
Monoclonal gammopathy of undetermined significance (MGUS) (MGUS) |
| Category |
Cancers |
| Sex |
|
| Adult |
Yes |
| UUID |
0646bdf5-f1d7-44f2-bcb3-1b44a81f0c7e |
| Definition |
A condition characterized by the abnormal presence of monoclonal immunoglobulins in the blood or urine. |
Ontologies
Key Summary Statistics
Cases from any source
| Total |
1361 |
| Female (%) |
624 (46%) |
| Male (%) |
737 (54%) |
Year first recorded
Cases linked in all UK Biobank sources
Cross-source concordance
Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.
Incidence & prevalence
Baseline prevalence stratified by sex
| Female |
7.43 (5.59,9.26) |
| Male |
8.54 (6.4,10.68) |
Incidence stratified by sex
| Female |
2.3 (1.91,2.7) |
| Male |
2.19 (1.77,2.61) |
Incidence stratified by age
| Ages 40-44 |
0.2 (-0.08,0.48) |
| Ages 45-49 |
0.96 (0.44,1.49) |
| Ages 50-54 |
1.08 (0.56,1.59) |
| Ages 55-59 |
1.3 (0.79,1.81) |
| Ages 60-64 |
3.38 (2.68,4.09) |
| Ages 65-69 |
4.53 (3.59,5.46) |
Period prevalence
Methods
Comparison with general population
Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)
| Population |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| UK Biobank |
4 (3,7) |
12 (9,15) |
30 (26,34) |
| CALIBER |
3 (2,3) |
8 (7,9) |
24 (22,25) |
Stratified by age and Townsend deprivation status
| Deprivation status |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| Least deprived |
7(2,17) |
13(8,21) |
25(18,33) |
| Low |
4(1,12) |
12(7,20) |
34(27,43) |
| Medium |
3(0,11) |
11(6,18) |
28(21,37) |
| High |
2(0,8) |
13(8,22) |
28(20,37) |
| Most deprived |
6(2,13) |
10(6,17) |
35(26,46) |
Stratified by age and country
| Country |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| England |
4(2,7) |
12(9,16) |
30(26,34) |
| Scotland |
6(1,19) |
3(1,10) |
30(20,42) |
| Wales |
4(0,21) |
23(12,41) |
31(19,47) |
Risk factors analysis
‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.
Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method
N=153561, Events=310
| Factor |
Level |
Hazard Ratio |
P value |
| BMI |
overweight |
0.89 (0.68, 1.17) |
0.406 |
| BMI |
obese |
1.13 (0.84, 1.51) |
0.416 |
| BMI |
underweight |
0 (0, Inf) |
0.987 |
| smoking |
previous |
0.95 (0.75, 1.22) |
0.699 |
| smoking |
current |
1.05 (0.72, 1.55) |
0.789 |
| hypertension |
yes |
1.12 (0.87, 1.45) |
0.386 |
Definition
| UK Biobank field id |
Description |
Code |
Value |
| 20002 |
Non-cancer illness code, self-reported |
1450 |
monoclonal gammopathy/not myeloma |
| 41202 |
Diagnoses - main ICD10 |
D47.2 |
Monoclonal gammopathy of undetermined significance (MGUS) |
| 41204 |
Diagnoses - secondary ICD10 |
D47.2 |
Monoclonal gammopathy of undetermined significance (MGUS) |
| 40001 |
Underlying (primary) cause of death: ICD10 |
D47.2 |
Monoclonal gammopathy of undetermined significance (MGUS) |
| 40002 |
Contributory (secondary) causes of death: ICD10 |
D47.2 |
Monoclonal gammopathy of undetermined significance (MGUS) |
| 42040 |
GP clinical event records |
BBm7.00 |
[M] Monoclonal gammopathy |
| 42040 |
GP clinical event records |
C331000 |
Monoclonal gammopathy of uncertain significance |
| 42040 |
GP clinical event records |
C331.00 |
Monoclonal paraproteinaemia |
| 42040 |
GP clinical event records |
C331.11 |
Monoclonal gammopathy |
| 42040 |
GP clinical event records |
C332200 |
Benign paraproteinaemia |
| 42040 |
GP clinical event records |
C332.00 |
Other paraproteinaemias |
| 42040 |
GP clinical event records |
C332z00 |
Paraproteinaemia NOS |
| 42040 |
GP clinical event records |
XaIt4 |
Benign paraproteinaemia |
| 42040 |
GP clinical event records |
XE11b |
Monoclonal paraproteinaemia |
| 42040 |
GP clinical event records |
XE11b |
Monoclonal paraproteinaemia |
| 42040 |
GP clinical event records |
Xa0SJ |
Monoclonal gammopathy of uncertain significance |
| 40006 |
Type of cancer: ICD10 |
D47.2 |
Monoclonal gammopathy of undetermined significance (MGUS) |