| Name |
Migraine (migraine) |
| Category |
Neurological |
| Sex |
|
| Adult |
Yes |
| UUID |
865e1810-5c77-4387-9b53-694d76360e6c |
| Definition |
A common, severe type of vascular headache often associated with increased sympathetic activity, resulting in nausea, vomiting, and light sensitivity. |
Ontologies
Key Summary Statistics
Cases from any source
| Total |
36612 |
| Female (%) |
28209 (77%) |
| Male (%) |
8403 (23%) |
Year first recorded
Cases linked in all UK Biobank sources
Cross-source concordance
Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.
Incidence & prevalence
Baseline prevalence stratified by sex
| Female |
1282.27 (1259.77,1304.77) |
| Male |
427.82 (412.98,442.66) |
Incidence stratified by sex
| Female |
27.77 (26.3,29.25) |
| Male |
12.43 (11.41,13.46) |
Incidence stratified by age
| Ages 40-44 |
39.37 (35.24,43.5) |
| Ages 45-49 |
30.49 (27.36,33.62) |
| Ages 50-54 |
20.61 (18.24,22.97) |
| Ages 55-59 |
16.97 (15.03,18.92) |
| Ages 60-64 |
15.65 (14.06,17.25) |
| Ages 65-69 |
13.97 (12.27,15.68) |
Period prevalence
Methods
Comparison with general population
Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)
| Population |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| UK Biobank |
1052 (1022,1083) |
944 (922,967) |
783 (765,801) |
| CALIBER |
945 (937,953) |
895 (886,903) |
778 (769,786) |
Stratified by age and Townsend deprivation status
| Deprivation status |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| Least deprived |
1027(956,1102) |
984(933,1038) |
829(790,870) |
| Low |
1091(1018,1169) |
949(898,1002) |
767(729,806) |
| Medium |
1073(1003,1147) |
935(885,987) |
788(750,829) |
| High |
1027(963,1093) |
921(872,972) |
803(762,845) |
| Most deprived |
1050(990,1114) |
928(879,980) |
722(681,764) |
Stratified by age and country
| Country |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| England |
1085(1051,1120) |
964(938,990) |
804(784,824) |
| Scotland |
792(719,871) |
778(723,836) |
698(650,748) |
| Wales |
1134(1019,1257) |
1034(951,1122) |
704(644,769) |
Risk factors analysis
‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.
Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method
N=153420, Events=132
| Factor |
Level |
Hazard Ratio |
P value |
| BMI |
overweight |
0.98 (0.66, 1.47) |
0.928 |
| BMI |
obese |
1.08 (0.69, 1.7) |
0.735 |
| BMI |
underweight |
0 (0, Inf) |
0.992 |
| smoking |
previous |
1.16 (0.78, 1.73) |
0.462 |
| smoking |
current |
2.27 (1.45, 3.57) |
0.000355 |
| hypertension |
yes |
1.19 (0.76, 1.85) |
0.449 |
Definition
| UK Biobank field id |
Description |
Code |
Value |
| 20002 |
Non-cancer illness code, self-reported |
1265 |
migraine |
| 41202 |
Diagnoses - main ICD10 |
G43 |
Migraine |
| 41204 |
Diagnoses - secondary ICD10 |
G43 |
Migraine |
| 40001 |
Underlying (primary) cause of death: ICD10 |
G43 |
Migraine |
| 40002 |
Contributory (secondary) causes of death: ICD10 |
G43 |
Migraine |
| 42040 |
GP clinical event records |
1474000.0 |
H/O migraine with aura |
| 42040 |
GP clinical event records |
1474.00 |
H/O: migraine |
| 42040 |
GP clinical event records |
8B6N.00 |
Migraine prophylaxis |
| 42040 |
GP clinical event records |
F260.00 |
Classical migraine |
| 42040 |
GP clinical event records |
F260.11 |
Migraine with aura |
| 42040 |
GP clinical event records |
F261000 |
Atypical migraine |
| 42040 |
GP clinical event records |
F261.00 |
Common migraine |
| 42040 |
GP clinical event records |
F261.11 |
Migraine without aura |
| 42040 |
GP clinical event records |
F261z00 |
Common migraine NOS |
| 42040 |
GP clinical event records |
F262200 |
Abdominal migraine |
| 42040 |
GP clinical event records |
F262300 |
Basilar migraine |
| 42040 |
GP clinical event records |
F262400 |
Ophthalmic migraine |
| 42040 |
GP clinical event records |
F262800 |
Migraine induced by oestrogen contraceptive |
| 42040 |
GP clinical event records |
F262.00 |
Migraine variants |
| 42040 |
GP clinical event records |
F262z00 |
Migraine variant NOS |
| 42040 |
GP clinical event records |
F26..00 |
Migraine |
| 42040 |
GP clinical event records |
F26y000 |
Hemiplegic migraine |
| 42040 |
GP clinical event records |
F26y100 |
Ophthalmoplegic migraine |
| 42040 |
GP clinical event records |
F26y111 |
Moebius’ ophthalmoplegic migraine |
| 42040 |
GP clinical event records |
F26y200 |
Status migrainosus |
| 42040 |
GP clinical event records |
F26y300 |
Complicated migraine |
| 42040 |
GP clinical event records |
F26y.00 |
Other forms of migraine |
| 42040 |
GP clinical event records |
F26yz00 |
Other forms of migraine NOS |
| 42040 |
GP clinical event records |
F26z.00 |
Migraine NOS |
| 42040 |
GP clinical event records |
Fyu5300 |
[X]Other migraine |
| 42040 |
GP clinical event records |
K584.11 |
Migraine - menstrual |
| 42040 |
GP clinical event records |
XaXkr |
Migraine induced by oestrogen contraceptive |
| 42040 |
GP clinical event records |
X007R |
Status migrainosus |
| 42040 |
GP clinical event records |
XE0el |
Premenstrual tension syndrome |
| 42040 |
GP clinical event records |
XaJLO |
Migraine prophylaxis |
| 42040 |
GP clinical event records |
XaXkv |
H/O migraine with aura |