| Name |
Motor neuron disease (MND) |
| Category |
Neurological |
| Sex |
|
| Adult |
Yes |
| UUID |
d274dfbb-ab34-416a-87a5-50e630afcfff |
| Definition |
A neurodegenerative disease that is located in the motor neurones. |
Ontologies
Key Summary Statistics
Cases from any source
| Total |
670 |
| Female (%) |
295 (44%) |
| Male (%) |
375 (56%) |
Year first recorded
Cases linked in all UK Biobank sources
Cross-source concordance
Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.
Incidence & prevalence
Baseline prevalence stratified by sex
| Female |
1.53 (0.7,2.37) |
| Male |
3.22 (1.9,4.54) |
Incidence stratified by sex
| Female |
0.51 (0.32,0.69) |
| Male |
0.93 (0.65,1.2) |
Incidence stratified by age
| Ages 40-44 |
0.1 (-0.1,0.3) |
| Ages 45-49 |
0.37 (0.05,0.7) |
| Ages 50-54 |
0.38 (0.08,0.68) |
| Ages 55-59 |
0.57 (0.23,0.91) |
| Ages 60-64 |
0.65 (0.34,0.96) |
| Ages 65-69 |
1.66 (1.09,2.22) |
Period prevalence
Methods
Comparison with general population
Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)
| Population |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| UK Biobank |
1 (1,3) |
6 (5,9) |
8 (6,10) |
| CALIBER |
2 (2,3) |
4 (4,5) |
10 (9,11) |
Stratified by age and Townsend deprivation status
| Deprivation status |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| Least deprived |
3(0,10) |
2(0,7) |
7(4,13) |
| Low |
1(0,7) |
6(2,12) |
9(5,14) |
| Medium |
0(NaN,NaN) |
5(2,10) |
8(4,13) |
| High |
2(0,8) |
8(3,14) |
10(6,16) |
| Most deprived |
0(NaN,NaN) |
11(6,19) |
5(2,9) |
Stratified by age and country
| Country |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| England |
2(0,4) |
6(4,9) |
8(6,10) |
| Scotland |
0(NaN,NaN) |
6(2,13) |
7(3,14) |
| Wales |
3(0,17) |
8(2,20) |
6(2,15) |
Definition
| UK Biobank field id |
Description |
Code |
Value |
| 20002 |
Non-cancer illness code, self-reported |
1259 |
motor neurone disease |
| 41202 |
Diagnoses - main ICD10 |
G12.2 |
Motor neuron disease |
| 41204 |
Diagnoses - secondary ICD10 |
G12.2 |
Motor neuron disease |
| 40001 |
Underlying (primary) cause of death: ICD10 |
G12.2 |
Motor neuron disease |
| 40002 |
Contributory (secondary) causes of death: ICD10 |
G12.2 |
Motor neuron disease |
| 42040 |
GP clinical event records |
7Q04100 |
Amyotrophic lateral sclerosis drugs Band 1 |
| 42040 |
GP clinical event records |
F152000 |
Amyotrophic lateral sclerosis |
| 42040 |
GP clinical event records |
F152100 |
Progressive muscular atrophy |
| 42040 |
GP clinical event records |
F152111 |
Duchenne Aran muscular atrophy |
| 42040 |
GP clinical event records |
F152200 |
Progressive bulbar palsy |
| 42040 |
GP clinical event records |
F152300 |
Pseudobulbar palsy |
| 42040 |
GP clinical event records |
F152400 |
Primary lateral sclerosis |
| 42040 |
GP clinical event records |
F152.00 |
Motor neurone disease |
| 42040 |
GP clinical event records |
F152z00 |
Motor neurone disease NOS |
| 42040 |
GP clinical event records |
F15..00 |
Anterior horn cell disease |
| 42040 |
GP clinical event records |
F15y.00 |
Other anterior horn cell disease |
| 42040 |
GP clinical event records |
F15z.00 |
Anterior horn cell disease NOS |
| 42040 |
GP clinical event records |
XaMEh |
Amyotrophic lateral sclerosis drugs Band 1 |