Multiple sclerosis

Metadata

Name	Multiple sclerosis (MS)
Category	Neurological
Sex
Adult	Yes
UUID	4711ebff-ecf7-4ccc-9537-e36dc7de1dc2
Definition	A demyelinating disease that involves damage to the fatty myelin sheaths around the axons of the brain and spinal cord resulting in demyelination and scarring.

Ontologies

Disease Ontology (DOID)	DOID_2377
GWAS Catalogue	EFO_0003885
MeSH	D009103
SNOMED-CT	24700007
FinnGen	G6_MS

Key Summary Statistics

Cases from any source

Total	2512
Female (%)	1815 (72%)
Male (%)	697 (28%)

Year first recorded

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Incidence & prevalence

Baseline prevalence stratified by sex

Female	57.17 (52.1,62.24)
Male	24.22 (20.61,27.82)

Incidence stratified by sex

Female	1.48 (1.17,1.8)
Male	1.01 (0.73,1.3)

Incidence stratified by age

Ages 40-44	2.83 (1.78,3.87)
Ages 45-49	1.72 (1.01,2.42)
Ages 50-54	1.59 (0.97,2.22)
Ages 55-59	1.1 (0.63,1.56)
Ages 60-64	0.73 (0.4,1.06)
Ages 65-69	0.81 (0.41,1.2)

Period prevalence

Methods

Comparison with general population

Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)

Population	Ages 40-49	Ages 50-59	Ages 60-69
UK Biobank	50 (44,58)	59 (53,65)	39 (35,43)
CALIBER	38 (37,40)	49 (47,51)	51 (49,53)

Stratified by age and Townsend deprivation status

Deprivation status	Ages 40-49	Ages 50-59	Ages 60-69
Least deprived	58(42,78)	65(52,80)	40(32,50)
Low	55(39,74)	53(42,67)	38(30,47)
Medium	34(22,50)	66(53,82)	39(30,48)
High	53(39,70)	55(43,69)	45(35,55)
Most deprived	53(40,69)	55(44,69)	33(25,43)

Stratified by age and country

Country	Ages 40-49	Ages 50-59	Ages 60-69
England	50(42,58)	57(51,63)	37(33,42)
Scotland	60(41,86)	71(55,90)	49(37,64)
Wales	43(23,73)	57(39,81)	39(26,57)

Risk factors analysis

‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.

Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method

N=153420, Events=132

Factor	Level	Hazard Ratio	P value
BMI	overweight	0.98 (0.66, 1.47)	0.928
BMI	obese	1.08 (0.69, 1.7)	0.735
BMI	underweight	0 (0, Inf)	0.992
smoking	previous	1.16 (0.78, 1.73)	0.462
smoking	current	2.27 (1.45, 3.57)	0.000355
hypertension	yes	1.19 (0.76, 1.85)	0.449

Definition

UK Biobank field id	Description	Code	Value
20002	Non-cancer illness code, self-reported	1261	multiple sclerosis
41202	Diagnoses - main ICD10	G35	Multiple sclerosis
41204	Diagnoses - secondary ICD10	G35	Multiple sclerosis
40001	Underlying (primary) cause of death: ICD10	G35	Multiple sclerosis
40002	Contributory (secondary) causes of death: ICD10	G35	Multiple sclerosis
42040	GP clinical event records	666A.00	Multiple sclerosis review
42040	GP clinical event records	666B.00	Multiple sclerosis multidisciplinary review
42040	GP clinical event records	8Cc0.00	Management of multiple sclerosis in onset phase
42040	GP clinical event records	8Cc1.00	Management of multiple sclerosis in early disease phase
42040	GP clinical event records	8Cc2.00	Management of multiple sclerosis in stable disability phase
42040	GP clinical event records	8Cc4.00	Management of multiple sclerosis in palliative phase
42040	GP clinical event records	8CS1.00	Multiple sclerosis care plan agreed
42040	GP clinical event records	8IAb.00	Multiple sclerosis review declined
42040	GP clinical event records	9kG..00	Spec serv for pat with multiple sclerosis - enh serv admin
42040	GP clinical event records	9mD0.00	Multiple sclerosis monitoring first letter
42040	GP clinical event records	9mD1.00	Multiple sclerosis monitoring second letter
42040	GP clinical event records	9mD..00	Multiple sclerosis monitoring administration
42040	GP clinical event records	F200.00	Multiple sclerosis of the brain stem
42040	GP clinical event records	F201.00	Multiple sclerosis of the spinal cord
42040	GP clinical event records	F202.00	Generalised multiple sclerosis
42040	GP clinical event records	F203.00	Exacerbation of multiple sclerosis
42040	GP clinical event records	F204.00	Benign multiple sclerosis
42040	GP clinical event records	F206.00	Primary progressive multiple sclerosis
42040	GP clinical event records	F207.00	Relapsing and remitting multiple sclerosis
42040	GP clinical event records	F208.00	Secondary progressive multiple sclerosis
42040	GP clinical event records	F20..00	Multiple sclerosis
42040	GP clinical event records	F20..11	Disseminated sclerosis
42040	GP clinical event records	F20z.00	Multiple sclerosis NOS
42040	GP clinical event records	XaX9F	Multiple sclerosis monitoring first letter
42040	GP clinical event records	XaX9A	Multiple sclerosis monitoring administration
42040	GP clinical event records	XaX9H	Multiple sclerosis monitoring second letter
42040	GP clinical event records	XaKzg	Multiple sclerosis care plan agreed
42040	GP clinical event records	XaPSc	Management of multiple sclerosis in palliative phase
42040	GP clinical event records	XaPSY	Management of multiple sclerosis in onset phase
42040	GP clinical event records	XaP0r	Primary progressive multiple sclerosis
42040	GP clinical event records	XaPSZ	Management of multiple sclerosis in early disease phase
42040	GP clinical event records	XaP1V	Secondary progressive multiple sclerosis
42040	GP clinical event records	XaPSa	Management of multiple sclerosis in stable disability phase
42040	GP clinical event records	XaKvn	Multiple sclerosis multidisciplinary review
42040	GP clinical event records	XaP1B	Relapsing and remitting multiple sclerosis
42040	GP clinical event records	XaOzZ	Benign multiple sclerosis
42040	GP clinical event records	XaKvm	Multiple sclerosis review
42040	GP clinical event records	XaQwl	Multiple sclerosis review declined