Metadata
| Name | Multiple valve dz (mult_valve) |
| Category | Cardiovascular |
| Sex | |
| Adult | Yes |
| UUID | b17ca73f-356a-4bb3-8910-b454ba94b5ce |
| Definition | The combination of stenotic or regurgitant lesions occurring on ?2 cardiac valves. |
Ontologies
| SNOMED-CT | 195002007 |
Key Summary Statistics
Cases from any source
| Total | 7066 |
| Female (%) | 3049 (43%) |
| Male (%) | 4017 (57%) |
Year first recorded
Cases linked in all UK Biobank sources
Cross-source concordance
Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.
Incidence & prevalence
Baseline prevalence stratified by sex
| Female | 9.55 (7.47,11.63) |
| Male | 12.32 (9.75,14.89) |
Incidence stratified by sex
| Female | 3.29 (2.82,3.76) |
| Male | 6.98 (6.23,7.73) |
Incidence stratified by age
| Ages 40-44 | 0.7 (0.18,1.22) |
| Ages 45-49 | 1.19 (0.61,1.77) |
| Ages 50-54 | 1.65 (1.01,2.28) |
| Ages 55-59 | 4.84 (3.86,5.82) |
| Ages 60-64 | 5.7 (4.78,6.61) |
| Ages 65-69 | 11.5 (10.0,12.99) |
Period prevalence
Methods
Comparison with general population
Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)
| Population | Ages 40-49 | Ages 50-59 | Ages 60-69 |
| UK Biobank | 9 (7,13) | 23 (20,28) | 59 (54,64) |
| CALIBER | 11 (10,12) | 29 (27,31) | 78 (75,81) |
Stratified by age and Townsend deprivation status
| Deprivation status | Ages 40-49 | Ages 50-59 | Ages 60-69 |
| Least deprived | 6(2,15) | 14(8,23) | 59(48,71) |
| Low | 3(0,10) | 17(11,26) | 60(50,72) |
| Medium | 8(3,17) | 22(14,32) | 51(41,62) |
| High | 10(5,19) | 30(21,41) | 55(44,67) |
| Most deprived | 16(9,26) | 33(24,44) | 72(59,86) |
Stratified by age and country
| Country | Ages 40-49 | Ages 50-59 | Ages 60-69 |
| England | 9(6,13) | 26(21,30) | 61(55,67) |
| Scotland | 11(4,26) | 13(7,23) | 51(38,66) |
| Wales | 7(1,24) | 20(10,37) | 50(34,70) |
Risk factors analysis
‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.
Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method
N=153996, Events=147
| Factor | Level | Hazard Ratio | P value |
| BMI | overweight | 0.93 (0.63, 1.37) | 0.695 |
| BMI | obese | 1 (0.64, 1.55) | 0.987 |
| BMI | underweight | 0 (0, Inf) | 0.994 |
| smoking | previous | 1.24 (0.87, 1.76) | 0.231 |
| smoking | current | 1.53 (0.9, 2.59) | 0.116 |
| hypertension | yes | 1.65 (1.18, 2.3) | 0.00322 |
Definition
| UK Biobank field id | Description | Code | Value |
|---|---|---|---|
| 41202 | Diagnoses - main ICD10 | I08 | Multiple valve diseases |
| 41204 | Diagnoses - secondary ICD10 | I08 | Multiple valve diseases |
| 40001 | Underlying (primary) cause of death: ICD10 | I08 | Multiple valve diseases |
| 40002 | Contributory (secondary) causes of death: ICD10 | I08 | Multiple valve diseases |
| 42040 | GP clinical event records | G130.00 | Mitral and aortic stenosis |
| 42040 | GP clinical event records | G131.00 | Mitral stenosis and aortic insufficiency |
| 42040 | GP clinical event records | G131.13 | Mitral stenosis and aortic incompetence |
| 42040 | GP clinical event records | G131.14 | Mitral stenosis and aortic regurgitation |
| 42040 | GP clinical event records | G132.00 | Mitral insufficiency and aortic stenosis |
| 42040 | GP clinical event records | G132.12 | Mitral incompetence and aortic stenosis |
| 42040 | GP clinical event records | G132.13 | Mitral regurgitation and aortic stenosis |
| 42040 | GP clinical event records | G133.00 | Mitral and aortic incompetence |
| 42040 | GP clinical event records | G133.11 | Mitral and aortic insufficiency |
| 42040 | GP clinical event records | G133.12 | Mitral and aortic regurgitation |
| 42040 | GP clinical event records | G13..00 | Diseases of mitral and aortic valves |
| 42040 | GP clinical event records | G13y.00 | Multiple mitral and aortic valve involvement |
| 42040 | GP clinical event records | G13z.00 | Mitral and aortic valve disease NOS |
| 42040 | GP clinical event records | G544000 | Disorders of both aortic and tricuspid valves |
| 42040 | GP clinical event records | G544100 | Disorders of both mitral and tricuspid valves |
| 42040 | GP clinical event records | G544200 | Combined disorders of mitral, aortic and tricuspid valves |
| 42040 | GP clinical event records | G544.00 | Multiple valve diseases |
| 42040 | GP clinical event records | G544X00 | Multiple valve disease, unspecified |
| 42040 | GP clinical event records | Gyu5D00 | [X]Multiple valve disorders/diseases CE |