| Name |
Myasthenia gravis (myasthenia) |
| Category |
Neurological |
| Sex |
|
| Adult |
Yes |
| UUID |
9962b89a-87bb-4806-aa8e-68de12a894cf |
| Definition |
A rare, clinically heterogeneous, autoimmune disorder of the neuromuscular junction characterized by fatigable weakness of voluntary muscles. |
Ontologies
Key Summary Statistics
Cases from any source
| Total |
433 |
| Female (%) |
209 (48%) |
| Male (%) |
224 (52%) |
Year first recorded
Cases linked in all UK Biobank sources
Cross-source concordance
Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.
Incidence & prevalence
Baseline prevalence stratified by sex
| Female |
4.95 (3.45,6.45) |
| Male |
4.48 (2.93,6.03) |
Incidence stratified by sex
| Female |
0.44 (0.27,0.61) |
| Male |
0.51 (0.3,0.71) |
Incidence stratified by age
| Ages 40-44 |
0.0 (0.0,0.0) |
| Ages 45-49 |
0.07 (-0.07,0.22) |
| Ages 50-54 |
0.38 (0.08,0.68) |
| Ages 55-59 |
0.36 (0.09,0.63) |
| Ages 60-64 |
0.5 (0.23,0.77) |
| Ages 65-69 |
1.1 (0.64,1.57) |
Period prevalence
Methods
Comparison with general population
Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)
| Population |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| UK Biobank |
3 (2,5) |
7 (5,9) |
9 (7,11) |
| CALIBER |
3 (2,3) |
4 (4,5) |
9 (8,9) |
Stratified by age and Townsend deprivation status
| Deprivation status |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| Least deprived |
4(1,13) |
5(2,11) |
4(2,8) |
| Low |
1(0,7) |
10(5,17) |
9(6,15) |
| Medium |
3(1,10) |
5(2,9) |
9(6,15) |
| High |
1(0,6) |
3(1,8) |
11(6,17) |
| Most deprived |
6(2,12) |
10(5,17) |
13(8,20) |
Stratified by age and country
| Country |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| England |
3(2,6) |
7(5,10) |
9(7,12) |
| Scotland |
6(1,19) |
4(1,11) |
11(6,19) |
| Wales |
0(NaN,NaN) |
5(1,16) |
7(2,17) |
Definition
| UK Biobank field id |
Description |
Code |
Value |
| 20002 |
Non-cancer illness code, self-reported |
1260 |
myasthenia gravis |
| 41202 |
Diagnoses - main ICD10 |
G70.0 |
Myasthenia gravis |
| 41204 |
Diagnoses - secondary ICD10 |
G70.0 |
Myasthenia gravis |
| 40001 |
Underlying (primary) cause of death: ICD10 |
G70.0 |
Myasthenia gravis |
| 40002 |
Contributory (secondary) causes of death: ICD10 |
G70.0 |
Myasthenia gravis |
| 42040 |
GP clinical event records |
F380100 |
Juvenile or adult myasthenia gravis |
| 42040 |
GP clinical event records |
F380.00 |
Myasthenia gravis |
| 42040 |
GP clinical event records |
F380z00 |
Myasthenia gravis NOS |