Mycoses

Metadata

Name	Mycoses (mycoses)
Category	Infections
Sex
Adult	Yes
UUID	24f8b493-8cf7-43be-9d1c-820d4c7a1b67
Definition	A disease by infectious agent that results_in infection, has_material_basis_in Fungi, which pass the resistance barriers of the human or animal body.

Ontologies

Disease Ontology (DOID)	DOID_1564
MeSH	D009181
SNOMED-CT	3218000
FinnGen	AB1_MYCOSES

Key Summary Statistics

Cases from any source

Total	7665
Female (%)	4046 (53%)
Male (%)	3619 (47%)

Year first recorded

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Incidence & prevalence

Baseline prevalence stratified by sex

Female	20.39 (17.36,23.43)
Male	18.9 (15.71,22.08)

Incidence stratified by sex

Female	6.91 (6.22,7.59)
Male	7.62 (6.83,8.4)

Incidence stratified by age

Ages 40-44	3.53 (2.36,4.7)
Ages 45-49	3.19 (2.24,4.15)
Ages 50-54	5.39 (4.25,6.54)
Ages 55-59	5.99 (4.89,7.08)
Ages 60-64	9.01 (7.86,10.17)
Ages 65-69	12.15 (10.62,13.68)

Period prevalence

Methods

Comparison with general population

Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)

Population	Ages 40-49	Ages 50-59	Ages 60-69
UK Biobank	43 (37,50)	50 (45,56)	82 (76,88)
CALIBER	44 (43,46)	59 (57,62)	103 (99,106)

Stratified by age and Townsend deprivation status

Deprivation status	Ages 40-49	Ages 50-59	Ages 60-69
Least deprived	36(24,53)	33(24,44)	63(52,75)
Low	45(31,63)	52(40,66)	77(65,91)
Medium	27(17,42)	42(31,54)	78(66,92)
High	49(36,66)	47(36,61)	91(78,107)
Most deprived	51(39,67)	74(60,90)	104(89,121)

Stratified by age and country

Country	Ages 40-49	Ages 50-59	Ages 60-69
England	46(39,53)	51(45,58)	88(81,95)
Scotland	25(13,44)	31(20,45)	50(37,65)
Wales	44(24,73)	66(46,92)	66(48,88)

Risk factors analysis

‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.

Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method

N=153969, Events=129

Factor	Level	Hazard Ratio	P value
BMI	overweight	1.18 (0.74, 1.86)	0.489
BMI	obese	1.91 (1.2, 3.06)	0.00685
BMI	underweight	0 (0, Inf)	0.995
smoking	previous	1.29 (0.88, 1.87)	0.189
smoking	current	1.41 (0.81, 2.45)	0.23
hypertension	yes	1.93 (1.34, 2.77)	0.000403

Definition

UK Biobank field id	Description	Code	Value
41202	Diagnoses - main ICD10	B20.4	HIV disease resulting in candidiasis
41202	Diagnoses - main ICD10	B20.5	HIV disease resulting in other mycoses
41202	Diagnoses - main ICD10	B20.6	HIV disease resulting in Pneumocystis jirovecii pneumonia
41202	Diagnoses - main ICD10	B35	Dermatophytosis
41202	Diagnoses - main ICD10	B36	Other superficial mycoses
41202	Diagnoses - main ICD10	B37	Candidiasis
41202	Diagnoses - main ICD10	B38	Coccidioidomycosis
41202	Diagnoses - main ICD10	B39	Histoplasmosis
41202	Diagnoses - main ICD10	B40	Blastomycosis
41202	Diagnoses - main ICD10	B41	Paracoccidioidomycosis
41202	Diagnoses - main ICD10	B42	Sporotrichosis
41202	Diagnoses - main ICD10	B43	Chromomycosis and phaeomycotic abscess
41202	Diagnoses - main ICD10	B44	Aspergillosis
41202	Diagnoses - main ICD10	B45	Cryptococcosis
41202	Diagnoses - main ICD10	B46	Zygomycosis
41202	Diagnoses - main ICD10	B47	Mycetoma
41202	Diagnoses - main ICD10	B48	Other mycoses, not elsewhere classified
41202	Diagnoses - main ICD10	B49	Unspecified mycosis
41202	Diagnoses - main ICD10	B59	Pneumocystosis
41202	Diagnoses - main ICD10	G02.1	Meningitis in mycoses
41202	Diagnoses - main ICD10	H62.2	Otitis externa in mycoses
41202	Diagnoses - main ICD10	J17.2	Pneumonia in mycoses
41202	Diagnoses - main ICD10	M01.6	Arthritis in mycoses
41204	Diagnoses - secondary ICD10	B20.4	HIV disease resulting in candidiasis
41204	Diagnoses - secondary ICD10	B20.5	HIV disease resulting in other mycoses
41204	Diagnoses - secondary ICD10	B20.6	HIV disease resulting in Pneumocystis jirovecii pneumonia
41204	Diagnoses - secondary ICD10	B35	Dermatophytosis
41204	Diagnoses - secondary ICD10	B36	Other superficial mycoses
41204	Diagnoses - secondary ICD10	B37	Candidiasis
41204	Diagnoses - secondary ICD10	B38	Coccidioidomycosis
41204	Diagnoses - secondary ICD10	B39	Histoplasmosis
41204	Diagnoses - secondary ICD10	B40	Blastomycosis
41204	Diagnoses - secondary ICD10	B41	Paracoccidioidomycosis
41204	Diagnoses - secondary ICD10	B42	Sporotrichosis
41204	Diagnoses - secondary ICD10	B43	Chromomycosis and phaeomycotic abscess
41204	Diagnoses - secondary ICD10	B44	Aspergillosis
41204	Diagnoses - secondary ICD10	B45	Cryptococcosis
41204	Diagnoses - secondary ICD10	B46	Zygomycosis
41204	Diagnoses - secondary ICD10	B47	Mycetoma
41204	Diagnoses - secondary ICD10	B48	Other mycoses, not elsewhere classified
41204	Diagnoses - secondary ICD10	B49	Unspecified mycosis
41204	Diagnoses - secondary ICD10	B59	Pneumocystosis
41204	Diagnoses - secondary ICD10	G02.1	Meningitis in mycoses
41204	Diagnoses - secondary ICD10	H62.2	Otitis externa in mycoses
41204	Diagnoses - secondary ICD10	J17.2	Pneumonia in mycoses
41204	Diagnoses - secondary ICD10	M01.6	Arthritis in mycoses
40001	Underlying (primary) cause of death: ICD10	B20.4	HIV disease resulting in candidiasis
40001	Underlying (primary) cause of death: ICD10	B20.5	HIV disease resulting in other mycoses
40001	Underlying (primary) cause of death: ICD10	B20.6	HIV disease resulting in Pneumocystis jirovecii pneumonia
40001	Underlying (primary) cause of death: ICD10	B35	Dermatophytosis
40001	Underlying (primary) cause of death: ICD10	B36	Other superficial mycoses
40001	Underlying (primary) cause of death: ICD10	B37	Candidiasis
40001	Underlying (primary) cause of death: ICD10	B38	Coccidioidomycosis
40001	Underlying (primary) cause of death: ICD10	B39	Histoplasmosis
40001	Underlying (primary) cause of death: ICD10	B40	Blastomycosis
40001	Underlying (primary) cause of death: ICD10	B41	Paracoccidioidomycosis
40001	Underlying (primary) cause of death: ICD10	B42	Sporotrichosis
40001	Underlying (primary) cause of death: ICD10	B43	Chromomycosis and phaeomycotic abscess
40001	Underlying (primary) cause of death: ICD10	B44	Aspergillosis
40001	Underlying (primary) cause of death: ICD10	B45	Cryptococcosis
40001	Underlying (primary) cause of death: ICD10	B46	Zygomycosis
40001	Underlying (primary) cause of death: ICD10	B47	Mycetoma
40001	Underlying (primary) cause of death: ICD10	B48	Other mycoses, not elsewhere classified
40001	Underlying (primary) cause of death: ICD10	B49	Unspecified mycosis
40001	Underlying (primary) cause of death: ICD10	B59	Pneumocystosis
40001	Underlying (primary) cause of death: ICD10	G02.1	Meningitis in mycoses
40001	Underlying (primary) cause of death: ICD10	H62.2	Otitis externa in mycoses
40001	Underlying (primary) cause of death: ICD10	J17.2	Pneumonia in mycoses
40001	Underlying (primary) cause of death: ICD10	M01.6	Arthritis in mycoses
40002	Contributory (secondary) causes of death: ICD10	B20.4	HIV disease resulting in candidiasis
40002	Contributory (secondary) causes of death: ICD10	B20.5	HIV disease resulting in other mycoses
40002	Contributory (secondary) causes of death: ICD10	B20.6	HIV disease resulting in Pneumocystis jirovecii pneumonia
40002	Contributory (secondary) causes of death: ICD10	B35	Dermatophytosis
40002	Contributory (secondary) causes of death: ICD10	B36	Other superficial mycoses
40002	Contributory (secondary) causes of death: ICD10	B37	Candidiasis
40002	Contributory (secondary) causes of death: ICD10	B38	Coccidioidomycosis
40002	Contributory (secondary) causes of death: ICD10	B39	Histoplasmosis
40002	Contributory (secondary) causes of death: ICD10	B40	Blastomycosis
40002	Contributory (secondary) causes of death: ICD10	B41	Paracoccidioidomycosis
40002	Contributory (secondary) causes of death: ICD10	B42	Sporotrichosis
40002	Contributory (secondary) causes of death: ICD10	B43	Chromomycosis and phaeomycotic abscess
40002	Contributory (secondary) causes of death: ICD10	B44	Aspergillosis
40002	Contributory (secondary) causes of death: ICD10	B45	Cryptococcosis
40002	Contributory (secondary) causes of death: ICD10	B46	Zygomycosis
40002	Contributory (secondary) causes of death: ICD10	B47	Mycetoma
40002	Contributory (secondary) causes of death: ICD10	B48	Other mycoses, not elsewhere classified
40002	Contributory (secondary) causes of death: ICD10	B49	Unspecified mycosis
40002	Contributory (secondary) causes of death: ICD10	B59	Pneumocystosis
40002	Contributory (secondary) causes of death: ICD10	G02.1	Meningitis in mycoses
40002	Contributory (secondary) causes of death: ICD10	H62.2	Otitis externa in mycoses
40002	Contributory (secondary) causes of death: ICD10	J17.2	Pneumonia in mycoses
40002	Contributory (secondary) causes of death: ICD10	M01.6	Arthritis in mycoses