Myocardial infarction

Metadata

Name	Myocardial infarction (myocardial_infarction)
Category	Cardiovascular
Sex
Adult	Yes
UUID	6e612160-fcb5-4d10-a8ed-01dfd2d68803
Definition	Gross necrosis of the myocardium, as a result of interruption of the blood supply to the area, as in coronary thrombosis.

Ontologies

Disease Ontology (DOID)	DOID_5844
GWAS Catalogue	EFO_0000612
MeSH	D009203
SNOMED-CT	22298006
FinnGen	I9_MI

Key Summary Statistics

Cases from any source

Total	27582
Female (%)	7383 (27%)
Male (%)	20199 (73%)

Year first recorded

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Incidence & prevalence

Baseline prevalence stratified by sex

Female	207.11 (197.53,216.69)
Male	723.77 (704.76,742.77)

Incidence stratified by sex

Female	3.37 (2.89,3.86)
Male	11.84 (10.82,12.86)

Incidence stratified by age

Ages 40-44	2.44 (1.46,3.41)
Ages 45-49	4.14 (3.05,5.23)
Ages 50-54	5.92 (4.7,7.13)
Ages 55-59	7.29 (6.06,8.52)
Ages 60-64	8.7 (7.53,9.86)
Ages 65-69	10.49 (9.0,11.98)

Period prevalence

Methods

Comparison with general population

Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)

Population	Ages 40-49	Ages 50-59	Ages 60-69
UK Biobank	133 (122,145)	321 (307,336)	675 (658,692)
CALIBER	89 (86,91)	271 (266,275)	558 (550,565)

Stratified by age and Townsend deprivation status

Deprivation status	Ages 40-49	Ages 50-59	Ages 60-69
Least deprived	83(63,107)	239(212,268)	538(505,572)
Low	100(78,128)	242(214,271)	597(562,632)
Medium	97(75,123)	308(277,341)	626(590,664)
High	122(100,148)	305(275,338)	709(669,751)
Most deprived	224(196,255)	499(461,539)	963(914,1013)

Stratified by age and country

Country	Ages 40-49	Ages 50-59	Ages 60-69
England	136(123,149)	330(314,347)	704(684,724)
Scotland	148(115,188)	292(256,331)	611(563,661)
Wales	82(52,123)	283(238,335)	466(415,521)

Risk factors analysis

‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.

Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method

N=147230, Events=709

Factor	Level	Hazard Ratio	P value
BMI	overweight	1.31 (1.08, 1.58)	0.00511
BMI	obese	1.42 (1.15, 1.75)	0.0011
BMI	underweight	0 (0, Inf)	0.982
smoking	previous	1.11 (0.94, 1.32)	0.217
smoking	current	2.52 (2.07, 3.07)	3.95e-20
hypertension	yes	1.42 (1.21, 1.67)	1.57e-05

Definition

UK Biobank field id	Description	Code	Value
6150	Vascular/heart problems diagnosed by doctor	1	heart attack
20002	Non-cancer illness code, self-reported	1075	heart attack/myocardial infarction
41202	Diagnoses - main ICD10	I25.2	Old myocardial infarction
41202	Diagnoses - main ICD10	I21	Acute myocardial infarction
41202	Diagnoses - main ICD10	I22	Subsequent myocardial infarction
41202	Diagnoses - main ICD10	I23	Certain current complications following acute myocardial infarction
41202	Diagnoses - main ICD10	I24.1	Dressler’s syndrome
41204	Diagnoses - secondary ICD10	I25.2	Old myocardial infarction
41204	Diagnoses - secondary ICD10	I21	Acute myocardial infarction
41204	Diagnoses - secondary ICD10	I22	Subsequent myocardial infarction
41204	Diagnoses - secondary ICD10	I23	Certain current complications following acute myocardial infarction
41204	Diagnoses - secondary ICD10	I24.1	Dressler’s syndrome
40001	Underlying (primary) cause of death: ICD10	I25.2	Old myocardial infarction
40001	Underlying (primary) cause of death: ICD10	I21	Acute myocardial infarction
40001	Underlying (primary) cause of death: ICD10	I22	Subsequent myocardial infarction
40001	Underlying (primary) cause of death: ICD10	I23	Certain current complications following acute myocardial infarction
40001	Underlying (primary) cause of death: ICD10	I24.1	Dressler’s syndrome
40002	Contributory (secondary) causes of death: ICD10	I25.2	Old myocardial infarction
40002	Contributory (secondary) causes of death: ICD10	I21	Acute myocardial infarction
40002	Contributory (secondary) causes of death: ICD10	I22	Subsequent myocardial infarction
40002	Contributory (secondary) causes of death: ICD10	I23	Certain current complications following acute myocardial infarction
40002	Contributory (secondary) causes of death: ICD10	I24.1	Dressler’s syndrome
42040	GP clinical event records	14A3.00	H/O: myocardial infarct <60
42040	GP clinical event records	14A4.00	H/O: myocardial infarct >60
42040	GP clinical event records	14AH.00	H/O: Myocardial infarction in last year
42040	GP clinical event records	G310.00	Postmyocardial infarction syndrome
42040	GP clinical event records	G32..00	Old myocardial infarction
42040	GP clinical event records	G32..11	Healed myocardial infarction
42040	GP clinical event records	G32..12	Personal history of myocardial infarction
42040	GP clinical event records	G33z500	Post infarct angina
42040	GP clinical event records	G30..11	Attack - heart
42040	GP clinical event records	G30..14	Heart attack
42040	GP clinical event records	G30..17	Silent myocardial infarction
42040	GP clinical event records	G30A.00	Mural thrombosis
42040	GP clinical event records	G30X000	Acute ST segment elevation myocardial infarction
42040	GP clinical event records	G307100	Acute non-ST segment elevation myocardial infarction
42040	GP clinical event records	323..00	ECG: myocardial infarction
42040	GP clinical event records	3233	ECG: antero-septal infarct.
42040	GP clinical event records	3234	ECG:posterior/inferior infarct
42040	GP clinical event records	3235	ECG: subendocardial infarct
42040	GP clinical event records	3236	ECG: lateral infarction
42040	GP clinical event records	323Z.00	ECG: myocardial infarct NOS
42040	GP clinical event records	889A.00	Diab mellit insulin-glucose infus acute myocardial infarct
42040	GP clinical event records	G30..00	Acute myocardial infarction
42040	GP clinical event records	G30..12	Coronary thrombosis
42040	GP clinical event records	G30..13	Cardiac rupture following myocardial infarction (MI)
42040	GP clinical event records	G30..15	MI - acute myocardial infarction
42040	GP clinical event records	G30..16	Thrombosis - coronary
42040	GP clinical event records	G300.00	Acute anterolateral infarction
42040	GP clinical event records	G301.00	Other specified anterior myocardial infarction
42040	GP clinical event records	G301000	Acute anteroapical infarction
42040	GP clinical event records	G301100	Acute anteroseptal infarction
42040	GP clinical event records	G301z00	Anterior myocardial infarction NOS
42040	GP clinical event records	G302.00	Acute inferolateral infarction
42040	GP clinical event records	G303.00	Acute inferoposterior infarction
42040	GP clinical event records	G304.00	Posterior myocardial infarction NOS
42040	GP clinical event records	G305.00	Lateral myocardial infarction NOS
42040	GP clinical event records	G306.00	True posterior myocardial infarction
42040	GP clinical event records	G307.00	Acute subendocardial infarction
42040	GP clinical event records	G307000	Acute non-Q wave infarction
42040	GP clinical event records	G308.00	Inferior myocardial infarction NOS
42040	GP clinical event records	G309.00	Acute Q-wave infarct
42040	GP clinical event records	G30B.00	Acute posterolateral myocardial infarction
42040	GP clinical event records	G30X.00	Acute transmural myocardial infarction of unspecif site
42040	GP clinical event records	G30y.00	Other acute myocardial infarction
42040	GP clinical event records	G30y000	Acute atrial infarction
42040	GP clinical event records	G30y100	Acute papillary muscle infarction
42040	GP clinical event records	G30y200	Acute septal infarction
42040	GP clinical event records	G30yz00	Other acute myocardial infarction NOS
42040	GP clinical event records	G30z.00	Acute myocardial infarction NOS
42040	GP clinical event records	G31y100	Microinfarction of heart
42040	GP clinical event records	G38..00	Postoperative myocardial infarction
42040	GP clinical event records	G380.00	Postoperative transmural myocardial infarction anterior wall
42040	GP clinical event records	G381.00	Postoperative transmural myocardial infarction inferior wall
42040	GP clinical event records	G384.00	Postoperative subendocardial myocardial infarction
42040	GP clinical event records	G38z.00	Postoperative myocardial infarction, unspecified
42040	GP clinical event records	Gyu3400	[X]Acute transmural myocardial infarction of unspecif site
42040	GP clinical event records	G35..00	Subsequent myocardial infarction
42040	GP clinical event records	G350.00	Subsequent myocardial infarction of anterior wall
42040	GP clinical event records	G351.00	Subsequent myocardial infarction of inferior wall
42040	GP clinical event records	G353.00	Subsequent myocardial infarction of other sites
42040	GP clinical event records	G35X.00	Subsequent myocardial infarction of unspecified site
42040	GP clinical event records	G310.11	Dressler’s syndrome
42040	GP clinical event records	G36..00	Certain current complication follow acute myocardial infarct
42040	GP clinical event records	G360.00	Haemopericardium/current comp folow acut myocard infarct
42040	GP clinical event records	G361.00	Atrial septal defect/curr comp folow acut myocardal infarct
42040	GP clinical event records	G362.00	Ventric septal defect/curr comp fol acut myocardal infarctn
42040	GP clinical event records	G363.00	Ruptur cardiac wall w’out haemopericard/cur comp fol ac MI
42040	GP clinical event records	G364.00	Ruptur chordae tendinae/curr comp fol acute myocard infarct
42040	GP clinical event records	G365.00	Rupture papillary muscle/curr comp fol acute myocard infarct
42040	GP clinical event records	G366.00	Thrombosis atrium,auric append&vent/curr comp foll acute MI
42040	GP clinical event records	G501.00	Post infarction pericarditis
42040	GP clinical event records	XaFx7	Diabetes mellitus insulin-glucose infusion in acute myocardial infarction
42040	GP clinical event records	XaIwY	Acute non-ST segment elevation myocardial infarction
42040	GP clinical event records	XE2aA	Old myocardial infarction
42040	GP clinical event records	XaEXt	Post infarct angina
42040	GP clinical event records	XaIwM	Acute ST segment elevation myocardial infarction
42040	GP clinical event records	XaD2i	Postoperative myocardial infarction, unspecified
42040	GP clinical event records	XaD2d	Postoperative transmural myocardial infarction of anterior wall
42040	GP clinical event records	XaD2b	Postoperative myocardial infarction
42040	GP clinical event records	XaAzi	Acute non-Q wave infarction
42040	GP clinical event records	XaD2e	Postoperative transmural myocardial infarction of inferior wall
42040	GP clinical event records	XE0Uh	Acute myocardial infarction
42040	GP clinical event records	XaBL1	H/O: Myocardial infarction in last year
42040	GP clinical event records	XaD2h	Postoperative subendocardial myocardial infarction
42040	GP clinical event records	XaJX0	Acute posterolateral myocardial infarction