Metadata
| Name | Nasal polyp (nasal_polyp) |
| Category | Respiratory |
| Sex | |
| Adult | Yes |
| UUID | e8c6d09a-f23b-4172-a220-14f4fb682998 |
| Definition | Nasal polyps are soft, painless, noncancerous growths on the lining of the nasal passages or sinuses |
Ontologies
| GWAS Catalogue | EFO_1000391 |
| MeSH | D009298 |
| SNOMED-CT | 32307003 |
| FinnGen | J10_NASALPOLYP |
Key Summary Statistics
Cases from any source
| Total | 9093 |
| Female (%) | 3327 (37%) |
| Male (%) | 5766 (63%) |
Year first recorded
Cases linked in all UK Biobank sources
Cross-source concordance
Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.
Incidence & prevalence
Baseline prevalence stratified by sex
| Female | 114.46 (107.3,121.62) |
| Male | 223.57 (212.73,234.41) |
Incidence stratified by sex
| Female | 4.36 (3.81,4.9) |
| Male | 9.54 (8.65,10.43) |
Incidence stratified by age
| Ages 40-44 | 5.49 (4.03,6.96) |
| Ages 45-49 | 5.4 (4.15,6.65) |
| Ages 50-54 | 6.23 (4.99,7.47) |
| Ages 55-59 | 6.24 (5.12,7.37) |
| Ages 60-64 | 7.34 (6.28,8.39) |
| Ages 65-69 | 8.19 (6.92,9.47) |
Period prevalence
Methods
Comparison with general population
Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)
| Population | Ages 40-49 | Ages 50-59 | Ages 60-69 |
| UK Biobank | 130 (119,142) | 172 (162,183) | 229 (219,239) |
| CALIBER | 104 (101,106) | 148 (144,152) | 205 (201,210) |
Stratified by age and Townsend deprivation status
| Deprivation status | Ages 40-49 | Ages 50-59 | Ages 60-69 |
| Least deprived | 161(133,193) | 183(160,209) | 233(212,256) |
| Low | 121(97,150) | 183(160,209) | 251(229,275) |
| Medium | 128(103,156) | 184(161,209) | 208(188,230) |
| High | 146(122,174) | 168(146,193) | 231(208,255) |
| Most deprived | 103(84,125) | 144(124,166) | 219(196,243) |
Stratified by age and country
| Country | Ages 40-49 | Ages 50-59 | Ages 60-69 |
| England | 132(120,145) | 173(161,185) | 230(219,242) |
| Scotland | 112(83,146) | 157(131,186) | 221(193,251) |
| Wales | 142(102,193) | 194(158,237) | 230(196,269) |
Risk factors analysis
‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.
Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method
N=153513, Events=116
| Factor | Level | Hazard Ratio | P value |
| BMI | overweight | 1.85 (1.14, 2.99) | 0.0128 |
| BMI | obese | 1.9 (1.12, 3.22) | 0.0174 |
| BMI | underweight | 0 (0, Inf) | 0.993 |
| smoking | previous | 0.82 (0.53, 1.27) | 0.367 |
| smoking | current | 1.79 (1.09, 2.95) | 0.0215 |
| hypertension | yes | 1.55 (1.01, 2.37) | 0.0432 |
Definition
| UK Biobank field id | Description | Code | Value |
|---|---|---|---|
| 20002 | Non-cancer illness code, self-reported | 1417 | nasal polyps |
| 20004 | Operation code | 1559 | nasal polyp surgery / nasal polypectomy |
| 41202 | Diagnoses - main ICD10 | J33 | Nasal polyp |
| 41204 | Diagnoses - secondary ICD10 | J33 | Nasal polyp |
| 41200 | Operative procedures - main OPCS4 | E08.1 | Polypectomy of internal nose |
| 41210 | Operative procedures - secondary OPCS4 | E08.1 | Polypectomy of internal nose |
| 40001 | Underlying (primary) cause of death: ICD10 | J33 | Nasal polyp |
| 40002 | Contributory (secondary) causes of death: ICD10 | J33 | Nasal polyp |
| 42040 | GP clinical event records | 2D33.00 | O/E - nasal polyp present |
| 42040 | GP clinical event records | 7402900.0 | Excision of polyp of nasal septum |
| 42040 | GP clinical event records | 7402911.0 | Nasal septum polypectomy |
| 42040 | GP clinical event records | 7406000.0 | Nasal polypectomy |
| 42040 | GP clinical event records | 7406700.0 | Nasal polypectomy using auto-debrider |
| 42040 | GP clinical event records | 7416F00 | Functional endoscopic sinus surg - polypectomy nasal sinus |
| 42040 | GP clinical event records | H110000 | Choanal polyp |
| 42040 | GP clinical event records | H110100 | Nasopharyngeal polyp |
| 42040 | GP clinical event records | H110.00 | Polyp of nasal cavity |
| 42040 | GP clinical event records | H110z00 | Polyp of nasal cavity NOS |
| 42040 | GP clinical event records | H111000 | Woakes’ ethmoiditis |
| 42040 | GP clinical event records | H111.00 | Polypoid sinus degeneration |
| 42040 | GP clinical event records | H111z00 | Polypoid sinus degeneration NOS |
| 42040 | GP clinical event records | H11..00 | Nasal polyps |
| 42040 | GP clinical event records | H11y000 | Polyp of frontal sinus |
| 42040 | GP clinical event records | H11y100 | Polyp of ethmoidal sinus |
| 42040 | GP clinical event records | H11y200 | Polyp of maxillary sinus |
| 42040 | GP clinical event records | H11y211 | Antral (maxillary) polyp |
| 42040 | GP clinical event records | H11y300 | Polyp of sphenoidal sinus |
| 42040 | GP clinical event records | H11y.00 | Other polyp of sinus |
| 42040 | GP clinical event records | H11y.11 | Nasal sinus polyps |
| 42040 | GP clinical event records | H11yz00 | Other polyp of sinus NOS |
| 42040 | GP clinical event records | H11z.00 | Nasal polyp NOS |
| 42040 | GP clinical event records | Hyu2300 | [X]Other polyp of sinus |
| 42040 | GP clinical event records | XE0Xv | Other polyp of sinus |
| 42040 | GP clinical event records | XaDyR | Nasal polypectomy using auto-debrider |
| 42040 | GP clinical event records | XaIwR | Functional endoscopic sinus surgery - polypectomy of nasal sinus |