Metadata

Name Non-Hodgkin Lymphoma (NHL)
Category Cancers
Sex
Adult Yes
UUID 80aab2b3-87e2-4cba-abf3-b7e78a1a1eb2
Definition Non-Hodgkin lymphoma (NHL) is a group of blood cancers that includes all types of lymphomas except Hodgkin lymphomas.

Ontologies

Disease Ontology (DOID) DOID_60060
GWAS Catalogue EFO_0005952
MeSH D008228
SNOMED-CT 118601006
FinnGen C3_NONHODGKIN

Key Summary Statistics

Cases from any source

Total 4199
Female (%) 1891 (45%)
Male (%) 2308 (55%)

Year first recorded

NHL year of first event

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Cross-sourced NHL cases

Incidence & prevalence

Sex and age-stratified incidence and prevalence of NHL

Baseline prevalence stratified by sex

Female 25.58 (22.18,28.98)
Male 35.56 (31.19,39.92)

Incidence stratified by sex

Female 3.81 (3.3,4.31)
Male 5.85 (5.16,6.54)

Incidence stratified by age

Ages 40-44 1.51 (0.75,2.28)
Ages 45-49 1.86 (1.13,2.59)
Ages 50-54 2.54 (1.75,3.32)
Ages 55-59 4.48 (3.54,5.43)
Ages 60-64 6.63 (5.64,7.63)
Ages 65-69 7.83 (6.59,9.06)

Period prevalence

Methods

Comparison with general population

Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)

CALIBER and UKB NHL prevalence comparison for multiple age groups

Population Ages 40-49 Ages 50-59 Ages 60-69
UK Biobank 24 (20,30) 39 (34,44) 79 (73,85)
CALIBER 16 (15,17) 31 (30,33) 63 (61,66)

Stratified by age and Townsend deprivation status

Deprivation status Ages 40-49 Ages 50-59 Ages 60-69
Least deprived 19(10,32) 38(28,51) 83(71,97)
Low 21(12,35) 32(23,44) 78(66,92)
Medium 22(13,36) 41(30,53) 72(60,85)
High 23(14,35) 39(29,51) 80(67,95)
Most deprived 33(23,46) 44(34,57) 79(66,94)

Stratified by age and country

Country Ages 40-49 Ages 50-59 Ages 60-69
England 25(20,31) 38(33,44) 81(75,88)
Scotland 26(13,45) 44(32,61) 69(55,87)
Wales 13(3,33) 35(21,55) 64(47,86)

Risk factors analysis

‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.

Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method

N=153561, Events=310

Factor Level Hazard Ratio P value
BMI overweight 0.89 (0.68, 1.17) 0.406
BMI obese 1.13 (0.84, 1.51) 0.416
BMI underweight 0 (0, Inf) 0.987
smoking previous 0.95 (0.75, 1.22) 0.699
smoking current 1.05 (0.72, 1.55) 0.789
hypertension yes 1.12 (0.87, 1.45) 0.386

Risk factors analysis forest plot

Definition

UK Biobank field id Description Code Value
20001 Cancer code, self-reported 1053 non-hodgkins lymphoma
41202 Diagnoses - main ICD10 C82 Follicular lymphoma
41202 Diagnoses - main ICD10 C83 Non-follicular lymphoma
41202 Diagnoses - main ICD10 C84 Mature T/NK-cell lymphomas
41202 Diagnoses - main ICD10 C85 Other and unspecified types of non-Hodgkin lymphoma
41202 Diagnoses - main ICD10 C86 Other specified types of T/NK-cell lymphoma
41204 Diagnoses - secondary ICD10 C82 Follicular lymphoma
41204 Diagnoses - secondary ICD10 C83 Non-follicular lymphoma
41204 Diagnoses - secondary ICD10 C84 Mature T/NK-cell lymphomas
41204 Diagnoses - secondary ICD10 C85 Other and unspecified types of non-Hodgkin lymphoma
41204 Diagnoses - secondary ICD10 C86 Other specified types of T/NK-cell lymphoma
40001 Underlying (primary) cause of death: ICD10 C82 Follicular lymphoma
40001 Underlying (primary) cause of death: ICD10 C83 Non-follicular lymphoma
40001 Underlying (primary) cause of death: ICD10 C84 Mature T/NK-cell lymphomas
40001 Underlying (primary) cause of death: ICD10 C85 Other and unspecified types of non-Hodgkin lymphoma
40001 Underlying (primary) cause of death: ICD10 C86 Other specified types of T/NK-cell lymphoma
40002 Contributory (secondary) causes of death: ICD10 C82 Follicular lymphoma
40002 Contributory (secondary) causes of death: ICD10 C83 Non-follicular lymphoma
40002 Contributory (secondary) causes of death: ICD10 C84 Mature T/NK-cell lymphomas
40002 Contributory (secondary) causes of death: ICD10 C85 Other and unspecified types of non-Hodgkin lymphoma
40002 Contributory (secondary) causes of death: ICD10 C86 Other specified types of T/NK-cell lymphoma
42040 GP clinical event records A789600 HIV disease resulting in Burkitt’s lymphoma
42040 GP clinical event records A789700 HIV dis resulting oth types of non-Hodgkin’s lymphoma
42040 GP clinical event records AyuC600 [X]HIV disease resulting in other non-Hodgkin’s lymphoma
42040 GP clinical event records B600000 Reticulosarcoma of unspecified site
42040 GP clinical event records B600100 Reticulosarcoma of lymph nodes of head, face and neck
42040 GP clinical event records B600300 Reticulosarcoma of intra-abdominal lymph nodes
42040 GP clinical event records B600700 Reticulosarcoma of spleen
42040 GP clinical event records B600.00 Reticulosarcoma
42040 GP clinical event records B600z00 Reticulosarcoma NOS
42040 GP clinical event records B601000 Lymphosarcoma of unspecified site
42040 GP clinical event records B601100 Lymphosarcoma of lymph nodes of head, face and neck
42040 GP clinical event records B601200 Lymphosarcoma of intrathoracic lymph nodes
42040 GP clinical event records B601300 Lymphosarcoma of intra-abdominal lymph nodes
42040 GP clinical event records B601500 Lymphosarcoma of lymph nodes of inguinal region and leg
42040 GP clinical event records B601700 Lymphosarcoma of spleen
42040 GP clinical event records B601800 Lymphosarcoma of lymph nodes of multiple sites
42040 GP clinical event records B601.00 Lymphosarcoma
42040 GP clinical event records B601z00 Lymphosarcoma NOS
42040 GP clinical event records B602100 Burkitt’s lymphoma of lymph nodes of head, face and neck
42040 GP clinical event records B602200 Burkitt’s lymphoma of intrathoracic lymph nodes
42040 GP clinical event records B602300 Burkitt’s lymphoma of intra-abdominal lymph nodes
42040 GP clinical event records B602500 Burkitt’s lymphoma of lymph nodes of inguinal region and leg
42040 GP clinical event records B602.00 Burkitt’s lymphoma
42040 GP clinical event records B602z00 Burkitt’s lymphoma NOS
42040 GP clinical event records B60..00 Lymphosarcoma and reticulosarcoma
42040 GP clinical event records B60y.00 Other specified reticulosarcoma or lymphosarcoma
42040 GP clinical event records B60z.00 Reticulosarcoma or lymphosarcoma NOS
42040 GP clinical event records B620000 Nodular lymphoma of unspecified site
42040 GP clinical event records B620100 Nodular lymphoma of lymph nodes of head, face and neck
42040 GP clinical event records B620200 Nodular lymphoma of intrathoracic lymph nodes
42040 GP clinical event records B620300 Nodular lymphoma of intra-abdominal lymph nodes
42040 GP clinical event records B620500 Nodular lymphoma of lymph nodes of inguinal region and leg
42040 GP clinical event records B620800 Nodular lymphoma of lymph nodes of multiple sites
42040 GP clinical event records B620.00 Nodular lymphoma (Brill - Symmers disease)
42040 GP clinical event records B620z00 Nodular lymphoma NOS
42040 GP clinical event records B621000 Mycosis fungoides of unspecified site
42040 GP clinical event records B621300 Mycosis fungoides of intra-abdominal lymph nodes
42040 GP clinical event records B621400 Mycosis fungoides of lymph nodes of axilla and upper limb
42040 GP clinical event records B621500 Mycosis fungoides of lymph nodes of inguinal region and leg
42040 GP clinical event records B621800 Mycosis fungoides of lymph nodes of multiple sites
42040 GP clinical event records B621.00 Mycosis fungoides
42040 GP clinical event records B621z00 Mycosis fungoides NOS
42040 GP clinical event records B622.00 Sezary’s disease
42040 GP clinical event records B622z00 Sezary’s disease NOS
42040 GP clinical event records B627000 Follicular non-Hodgkin’s small cleaved cell lymphoma
42040 GP clinical event records B627100 Follicular non-Hodg mixed sml cleavd & lge cell lymphoma
42040 GP clinical event records B627200 Follicular non-Hodgkin’s large cell lymphoma
42040 GP clinical event records B627300 Diffuse non-Hodgkin’s small cell (diffuse) lymphoma
42040 GP clinical event records B627400 Diffuse non-Hodgkin’s small cleaved cell (diffuse) lymphoma
42040 GP clinical event records B627500 Diffuse non-Hodgkin mixed sml & lge cell (diffuse) lymphoma
42040 GP clinical event records B627600 Diffuse non-Hodgkin’s immunoblastic (diffuse) lymphoma
42040 GP clinical event records B627700 Diffuse non-Hodgkin’s lymphoblastic (diffuse) lymphoma
42040 GP clinical event records B627800 Diffuse non-Hodgkin’s lymphoma undifferentiated (diffuse)
42040 GP clinical event records B627900 Mucosa-associated lymphoma
42040 GP clinical event records B627911 Maltoma
42040 GP clinical event records B627A00 Diffuse non-Hodgkin’s large cell lymphoma
42040 GP clinical event records B627.00 Non - Hodgkin’s lymphoma
42040 GP clinical event records B627.11 Non-Hodgkin lymphoma
42040 GP clinical event records B627B00 Other types of follicular non-Hodgkin’s lymphoma
42040 GP clinical event records B627C00 Follicular non-Hodgkin’s lymphoma
42040 GP clinical event records B627C11 Follicular lymphoma NOS
42040 GP clinical event records B627D00 Diffuse non-Hodgkin’s centroblastic lymphoma
42040 GP clinical event records B627E00 Diffuse large B-cell lymphoma
42040 GP clinical event records B627F00 Extranod marg zone B-cell lymphom mucosa-assoc lymphoid tiss
42040 GP clinical event records B627G00 Mediastinal (thymic) large B-cell lymphoma
42040 GP clinical event records B627W00 Unspecified B-cell non-Hodgkin’s lymphoma
42040 GP clinical event records B627X00 Diffuse non-Hodgkin’s lymphoma, unspecified
42040 GP clinical event records B628000 Follicular lymphoma grade 1
42040 GP clinical event records B628100 Follicular lymphoma grade 2
42040 GP clinical event records B628200 Follicular lymphoma grade 3
42040 GP clinical event records B628300 Follicular lymphoma grade 3a
42040 GP clinical event records B628400 Follicular lymphoma grade 3b
42040 GP clinical event records B628500 Diffuse follicle centre lymphoma
42040 GP clinical event records B628600 Cutaneous follicle centre lymphoma
42040 GP clinical event records B628700 Other types of follicular lymphoma
42040 GP clinical event records B628.00 Follicular lymphoma
42040 GP clinical event records B62E100 Anaplastic large cell lymphoma, ALK-positive
42040 GP clinical event records B62E200 Anaplastic large cell lymphoma, ALK-negative
42040 GP clinical event records B62E300 Cutaneous T-cell lymphoma
42040 GP clinical event records B62E400 Extranodal NK/T-cell lymphoma, nasal type
42040 GP clinical event records B62E500 Hepatosplenic T-cell lymphoma
42040 GP clinical event records B62E600 Enteropathy-associated T-cell lymphoma
42040 GP clinical event records B62E700 Subcutaneous panniculitic T-cell lymphoma
42040 GP clinical event records B62E800 Blastic NK-cell lymphoma
42040 GP clinical event records B62E900 Angioimmunoblastic T-cell lymphoma
42040 GP clinical event records B62EA00 Primary cutaneous CD30-positive T-cell proliferations
42040 GP clinical event records B62E.00 T/NK-cell lymphoma
42040 GP clinical event records B62Ew00 Other mature T/NK-cell lymphoma
42040 GP clinical event records B62F000 Small cell B-cell lymphoma
42040 GP clinical event records B62F100 Mantle cell lymphoma
42040 GP clinical event records B62F200 Lymphoblastic (diffuse) lymphoma
42040 GP clinical event records B62F.00 Nonfollicular lymphoma
42040 GP clinical event records B62F.11 Non-follicular lymphoma
42040 GP clinical event records B62x000 T-zone lymphoma
42040 GP clinical event records B62x100 Lymphoepithelioid lymphoma
42040 GP clinical event records B62x200 Peripheral T-cell lymphoma
42040 GP clinical event records B62x400 Malignant reticulosis
42040 GP clinical event records B62x500 Malignant immunoproliferative small intestinal disease
42040 GP clinical event records B62x.00 Malignant lymphoma otherwise specified
42040 GP clinical event records B62xX00 Oth and unspecif peripheral & cutaneous T-cell lymphomas
42040 GP clinical event records B62y000 Malignant lymphoma NOS of unspecified site
42040 GP clinical event records B62y100 Malignant lymphoma NOS of lymph nodes of head, face and neck
42040 GP clinical event records B62y200 Malignant lymphoma NOS of intrathoracic lymph nodes
42040 GP clinical event records B62y300 Malignant lymphoma NOS of intra-abdominal lymph nodes
42040 GP clinical event records B62y400 Malignant lymphoma NOS of lymph nodes of axilla and arm
42040 GP clinical event records B62y500 Malignant lymphoma NOS of lymph node inguinal region and leg
42040 GP clinical event records B62y600 Malignant lymphoma NOS of intrapelvic lymph nodes
42040 GP clinical event records B62y700 Malignant lymphoma NOS of spleen
42040 GP clinical event records B62y800 Malignant lymphoma NOS of lymph nodes of multiple sites
42040 GP clinical event records B62y.00 Malignant lymphoma NOS
42040 GP clinical event records B62yz00 Malignant lymphoma NOS
42040 GP clinical event records BBg1000 [M]Malignant lymphoma, diffuse NOS
42040 GP clinical event records BBg1.00 [M]Malignant lymphoma NOS
42040 GP clinical event records BBg1.11 [M]Lymphoma NOS
42040 GP clinical event records BBg2.00 [M]Malignant lymphoma, non Hodgkin’s type
42040 GP clinical event records BBg2.11 [M]Non Hodgkins lymphoma
42040 GP clinical event records BBg3.00 [M]Malignant lymphoma, undifferentiated cell type NOS
42040 GP clinical event records BBg4.00 [M]Malignant lymphoma, stem cell type
42040 GP clinical event records BBg5.00 [M]Malignant lymphoma, convoluted cell type NOS
42040 GP clinical event records BBg6.00 [M]Lymphosarcoma NOS
42040 GP clinical event records BBg7.00 [M]Malignant lymphoma, lymphoplasmacytoid type
42040 GP clinical event records BBg8.00 [M]Malignant lymphoma, immunoblastic type
42040 GP clinical event records BBgA.00 [M]Malignant lymphoma, centroblastic-centrocytic, diffuse
42040 GP clinical event records BBgB.00 [M]Malignant lymphoma, follicular centre cell NOS
42040 GP clinical event records BBg..00 [M]Lymphomas, NOS or diffuse
42040 GP clinical event records BBgC.00 [M]Malignant lymphoma, lymphocytic, well differentiated NOS
42040 GP clinical event records BBgC.11 [M]Lymphocytic lymphoma NOS
42040 GP clinical event records BBgC.12 [M]Lymphocytic lymphosarcoma NOS
42040 GP clinical event records BBgD.00 [M]Malig lymphoma, lymphocytic, intermediate different NOS
42040 GP clinical event records BBgE.00 [M]Malignant lymphoma, centrocytic
42040 GP clinical event records BBgG.00 [M]Malignant lymphoma, lymphocytic, poorly different NOS
42040 GP clinical event records BBgG.11 [M]Lymphoblastic lymphosarcoma NOS
42040 GP clinical event records BBgG.12 [M]Lymphoblastic lymphoma NOS
42040 GP clinical event records BBgG.13 [M]Lymphoblastoma NOS
42040 GP clinical event records BBgH.00 [M]Prolymphocytic lymphosarcoma
42040 GP clinical event records BBgJ.00 [M]Malignant lymphoma, centroblastic type NOS
42040 GP clinical event records BBgK.00 [M]Malig lymphoma, follicular centre cell, non-cleaved NOS
42040 GP clinical event records BBgL.00 [M]Malignant lymphoma, small lymphocytic NOS
42040 GP clinical event records BBgM.00 [M]Malignant lymphoma, small cleaved cell, diffuse
42040 GP clinical event records BBgN.00 [M]Malign lymphoma,lymphocytic,intermediate differn, diffuse
42040 GP clinical event records BBgP.00 [M]Malignant lymphoma, mixed small and large cell, diffuse
42040 GP clinical event records BBgQ.00 [M]Malignant lymphomatous polyposis
42040 GP clinical event records BBgR.00 [M]Malignant lymphoma, large cell, diffuse NOS
42040 GP clinical event records BBgS.00 [M]Malignant lymphoma, large cell, cleaved, diffuse
42040 GP clinical event records BBgT.00 [M]Malignant lymphoma, large cell, noncleaved, diffuse
42040 GP clinical event records BBgV.00 [M]Malignant lymphoma, small cell, noncleaved, diffuse
42040 GP clinical event records BBgz.00 [M]Lymphoma, diffuse or NOS
42040 GP clinical event records BBh0.00 [M]Reticulosarcoma NOS
42040 GP clinical event records BBh2.00 [M]Reticulosarcoma, nodular
42040 GP clinical event records BBh..00 [M]Reticulosarcomas
42040 GP clinical event records BBk0.00 [M]Malignant lymphoma, nodular NOS
42040 GP clinical event records BBk0.11 [M]Brill - Symmers’ disease
42040 GP clinical event records BBk0.12 [M]Follicular lymphosarcoma NOS
42040 GP clinical event records BBk0.13 [M]Giant follicular lymphoma
42040 GP clinical event records BBk2.00 [M]Malignant lymphoma, centroblastic-centrocytic, follicular
42040 GP clinical event records BBk3.00 [M]Malig lymphoma, lymphocytic, well differentiated,nodular
42040 GP clinical event records BBk5.00 [M]Malig lymp, follicular centre cell, cleaved, follicular
42040 GP clinical event records BBk7.00 [M]Malignant lymphoma, centroblastic type, follicular
42040 GP clinical event records BBk8.00 [M]Malig lymp,follicular centre cell,noncleaved,follicular
42040 GP clinical event records BBk..00 [M]Lymphomas, nodular or follicular
42040 GP clinical event records BBkz.00 [M]Lymphoma, nodular or follicular NOS
42040 GP clinical event records BBl0.00 [M]Mycosis fungoides
42040 GP clinical event records BBl1.00 [M]Sezary’s disease
42040 GP clinical event records BBl..00 [M]Mycosis fungoides
42040 GP clinical event records BBlz.00 [M]Mycosis fungoides NOS
42040 GP clinical event records BBm0.00 [M]Microglioma
42040 GP clinical event records BBm1.11 [M]Malignant reticulosis
42040 GP clinical event records BBm5.00 [M] Peripheral T-cell lymphoma NOS
42040 GP clinical event records BBm8.00 [M] Angioimmunoblastic lymphadenopathy
42040 GP clinical event records BBm9.00 [M] Monocytoid B-cell lymphoma
42040 GP clinical event records BBmD.00 [M] Cutaneous lymphoma
42040 GP clinical event records BBmF.00 [M] Angiocentric immunoproliferative lesion
42040 GP clinical event records BBmH.00 [M] Large cell lymphoma
42040 GP clinical event records BBmJ.00 [M] Angioendotheliomatosis
42040 GP clinical event records BBv0.00 [M]Monocytoid B-cell lymphoma
42040 GP clinical event records BBv2.00 [M]AngiocentricT-cell lymphoma
42040 GP clinical event records ByuD100 [X]Other types of follicular non-Hodgkin’s lymphoma
42040 GP clinical event records ByuD200 [X]Other types of diffuse non-Hodgkin’s lymphoma
42040 GP clinical event records ByuD300 [X]Other specified types of non-Hodgkin’s lymphoma
42040 GP clinical event records ByuDC00 [X]Diffuse non-Hodgkin’s lymphoma, unspecified
42040 GP clinical event records ByuDD00 [X]Oth and unspecif peripheral & cutaneous T-cell lymphomas
42040 GP clinical event records ByuDE00 [X]Unspecified B-cell non-Hodgkin’s lymphoma
42040 GP clinical event records ByuDF00 [X]Non-Hodgkin’s lymphoma, unspecified type
42040 GP clinical event records ByuDF11 [X]Non-Hodgkin’s lymphoma NOS
42040 GP clinical event records M162800 Lymphomatoid papulosis
42040 GP clinical event records XaPQD Mantle cell lymphoma
42040 GP clinical event records XaYij Follicular lymphoma grade 1
42040 GP clinical event records Xa0Th Peripheral T-cell lymphoma
42040 GP clinical event records Xa0Tu Enteropathy-associated T-cell lymphoma
42040 GP clinical event records Xa0Tu Enteropathy-associated T-cell lymphoma
42040 GP clinical event records XaBLw Follicular non-Hodgkin’s lymphoma
42040 GP clinical event records XaBLw Follicular non-Hodgkin’s lymphoma
42040 GP clinical event records XaZdn Diffuse large B-cell lymphoma
42040 GP clinical event records XE1wf [M]Malignant lymphoma, nodular NOS
42040 GP clinical event records XaZdD Follicular lymphoma grade 3
42040 GP clinical event records XaZdF Follicular lymphoma grade 2
42040 GP clinical event records XaYiN Hepatosplenic T-cell lymphoma
42040 GP clinical event records Xa0Ti T-zone lymphoma
42040 GP clinical event records XaYjf Subcutaneous panniculitic T-cell lymphoma
42040 GP clinical event records XaYi5 Diffuse follicle centre lymphoma
42040 GP clinical event records XaYii Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue
42040 GP clinical event records XaYim Follicular lymphoma grade 3b
42040 GP clinical event records Xa0T8 Mucosa-associated lymphoma
42040 GP clinical event records Xa0Tj Lymphoepithelioid lymphoma
42040 GP clinical event records B62y. Malignant lymphoma NOS
42040 GP clinical event records BBl.. [M]Mycosis fungoides
42040 GP clinical event records XaYil Follicular lymphoma grade 3a
42040 GP clinical event records X50BR Lymphomatoid papulosis
42040 GP clinical event records XE2t9 [X]Non-Hodgkin’s lymphoma, unspecified type
42040 GP clinical event records XaYin Cutaneous follicle centre lymphoma
40006 Type of cancer: ICD10 C82 Follicular lymphoma
40006 Type of cancer: ICD10 C83 Non-follicular lymphoma
40006 Type of cancer: ICD10 C84 Mature T/NK-cell lymphomas
40006 Type of cancer: ICD10 C85 Other and unspecified types of non-Hodgkin lymphoma
40006 Type of cancer: ICD10 C86 Other specified types of T/NK-cell lymphoma