Metadata
| Name | Nonrheumatic aortic valve disorders (nonRh_aortic) |
| Category | Cardiovascular |
| Sex | |
| Adult | Yes |
| UUID | 12786fed-3ba5-4af3-8cbf-daa0c79c4d6e |
| Definition | Nonrheumatic aortic valve disorders |
Ontologies
| Disease Ontology (DOID) | DOID_62 |
| GWAS Catalogue | EFO_0009531 |
| MeSH | D000082862 |
| SNOMED-CT | 8722008 |
Key Summary Statistics
Cases from any source
| Total | 7940 |
| Female (%) | 3036 (38%) |
| Male (%) | 4904 (62%) |
Year first recorded
Cases linked in all UK Biobank sources
Cross-source concordance
Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.
Incidence & prevalence
Baseline prevalence stratified by sex
| Female | 28.64 (25.05,32.24) |
| Male | 54.74 (49.33,60.15) |
Incidence stratified by sex
| Female | 5.82 (5.19,6.45) |
| Male | 11.69 (10.71,12.66) |
Incidence stratified by age
| Ages 40-44 | 1.21 (0.52,1.89) |
| Ages 45-49 | 2.38 (1.55,3.2) |
| Ages 50-54 | 3.3 (2.4,4.2) |
| Ages 55-59 | 6.79 (5.62,7.95) |
| Ages 60-64 | 10.44 (9.19,11.68) |
| Ages 65-69 | 19.59 (17.63,21.54) |
Period prevalence
Methods
Comparison with general population
Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)
| Population | Ages 40-49 | Ages 50-59 | Ages 60-69 |
| UK Biobank | 24 (19,29) | 51 (45,56) | 141 (133,149) |
| CALIBER | 19 (18,20) | 48 (46,50) | 141 (138,145) |
Stratified by age and Townsend deprivation status
| Deprivation status | Ages 40-49 | Ages 50-59 | Ages 60-69 |
| Least deprived | 19(10,33) | 36(26,48) | 124(109,141) |
| Low | 24(14,38) | 38(28,51) | 152(135,171) |
| Medium | 31(19,46) | 49(37,63) | 119(104,136) |
| High | 20(12,32) | 60(47,76) | 125(108,143) |
| Most deprived | 24(16,36) | 69(55,84) | 189(168,212) |
Stratified by age and country
| Country | Ages 40-49 | Ages 50-59 | Ages 60-69 |
| England | 23(18,28) | 50(44,56) | 136(128,145) |
| Scotland | 21(10,39) | 53(39,71) | 159(136,185) |
| Wales | 37(19,67) | 55(37,79) | 161(132,194) |
Risk factors analysis
‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.
Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method
N=147230, Events=709
| Factor | Level | Hazard Ratio | P value |
| BMI | overweight | 1.31 (1.08, 1.58) | 0.00511 |
| BMI | obese | 1.42 (1.15, 1.75) | 0.0011 |
| BMI | underweight | 0 (0, Inf) | 0.982 |
| smoking | previous | 1.11 (0.94, 1.32) | 0.217 |
| smoking | current | 2.52 (2.07, 3.07) | 3.95e-20 |
| hypertension | yes | 1.42 (1.21, 1.67) | 1.57e-05 |
Definition
| UK Biobank field id | Description | Code | Value |
|---|---|---|---|
| 41202 | Diagnoses - main ICD10 | I35 | Nonrheumatic aortic valve disorders |
| 41204 | Diagnoses - secondary ICD10 | I35 | Nonrheumatic aortic valve disorders |
| 40001 | Underlying (primary) cause of death: ICD10 | I35 | Nonrheumatic aortic valve disorders |
| 40002 | Contributory (secondary) causes of death: ICD10 | I35 | Nonrheumatic aortic valve disorders |
| 42040 | GP clinical event records | G541000 | Aortic incompetence, non-rheumatic |
| 42040 | GP clinical event records | G541011 | Aortic insufficiency, non-rheumatic |
| 42040 | GP clinical event records | G541012 | Aortic regurgitation, non-rheumatic |
| 42040 | GP clinical event records | G541100 | Aortic stenosis, non-rheumatic |
| 42040 | GP clinical event records | G541200 | Aortic incompetence alone, cause unspecified |
| 42040 | GP clinical event records | G541211 | Aortic insufficiency alone, cause unspecified |
| 42040 | GP clinical event records | G541212 | Aortic regurgitation alone, cause unspecified |
| 42040 | GP clinical event records | G541300 | Aortic stenosis alone, cause unspecified |
| 42040 | GP clinical event records | G541400 | Aortic valve stenosis with insufficiency |
| 42040 | GP clinical event records | G541500 | Aortic stenosis |
| 42040 | GP clinical event records | G541600 | Aortic valve sclerosis |
| 42040 | GP clinical event records | G541700 | Aortic valve calcification |
| 42040 | GP clinical event records | G541.00 | Aortic valve disorders |
| 42040 | GP clinical event records | G541z00 | Aortic valve disorders NOS |
| 42040 | GP clinical event records | Gyu1100 | [X]Other rheumatic aortic valve diseases |
| 42040 | GP clinical event records | Gyu5600 | [X]Other aortic valve disorders |
| 42040 | GP clinical event records | Gyu5A00 | [X]Aortic valve disorders in diseases classified elsewhere |
| 42040 | GP clinical event records | XSDVN | Aortic valve sclerosis |
| 42040 | GP clinical event records | X2011 | Aortic stenosis |
| 42040 | GP clinical event records | X777c | Aortic valve calcification |