| Name |
Nonrheumatic mitral valve disorders (nonRh_mitral) |
| Category |
Cardiovascular |
| Sex |
|
| Adult |
Yes |
| UUID |
b7b5dd9a-c9e9-4ecd-ae5a-84097d70381c |
| Definition |
Abnormalities of a valve in the heart that are not caused by or related to rheumatism and affect the way that the blood flows from the heart. |
Ontologies
Key Summary Statistics
Cases from any source
| Total |
7042 |
| Female (%) |
3296 (47%) |
| Male (%) |
3746 (53%) |
Year first recorded
Cases linked in all UK Biobank sources
Cross-source concordance
Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.
Incidence & prevalence
Baseline prevalence stratified by sex
| Female |
44.32 (39.85,48.79) |
| Male |
48.72 (43.61,53.82) |
Incidence stratified by sex
| Female |
5.19 (4.6,5.79) |
| Male |
7.52 (6.74,8.3) |
Incidence stratified by age
| Ages 40-44 |
1.41 (0.67,2.15) |
| Ages 45-49 |
2.38 (1.55,3.2) |
| Ages 50-54 |
3.31 (2.41,4.21) |
| Ages 55-59 |
5.27 (4.24,6.3) |
| Ages 60-64 |
7.23 (6.19,8.26) |
| Ages 65-69 |
13.35 (11.74,14.97) |
Period prevalence
Methods
Comparison with general population
Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)
| Population |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| UK Biobank |
30 (25,36) |
58 (53,65) |
114 (108,122) |
| CALIBER |
35 (34,37) |
68 (65,70) |
137 (133,141) |
Stratified by age and Townsend deprivation status
| Deprivation status |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| Least deprived |
24(14,38) |
49(38,63) |
113(98,129) |
| Low |
16(8,29) |
48(37,61) |
116(101,132) |
| Medium |
45(32,63) |
57(45,72) |
106(92,122) |
| High |
34(23,48) |
69(56,85) |
109(94,126) |
| Most deprived |
30(20,42) |
67(54,82) |
130(113,149) |
Stratified by age and country
| Country |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| England |
29(24,36) |
55(48,61) |
106(99,114) |
| Scotland |
28(15,47) |
72(56,92) |
163(139,189) |
| Wales |
41(22,71) |
72(50,99) |
131(105,161) |
Risk factors analysis
‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.
Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method
N=147230, Events=709
| Factor |
Level |
Hazard Ratio |
P value |
| BMI |
overweight |
1.31 (1.08, 1.58) |
0.00511 |
| BMI |
obese |
1.42 (1.15, 1.75) |
0.0011 |
| BMI |
underweight |
0 (0, Inf) |
0.982 |
| smoking |
previous |
1.11 (0.94, 1.32) |
0.217 |
| smoking |
current |
2.52 (2.07, 3.07) |
3.95e-20 |
| hypertension |
yes |
1.42 (1.21, 1.67) |
1.57e-05 |
Definition
| UK Biobank field id |
Description |
Code |
Value |
| 20002 |
Non-cancer illness code, self-reported |
1488 |
mitral valve prolapse |
| 41202 |
Diagnoses - main ICD10 |
I34 |
Nonrheumatic mitral valve disorders |
| 41204 |
Diagnoses - secondary ICD10 |
I34 |
Nonrheumatic mitral valve disorders |
| 40001 |
Underlying (primary) cause of death: ICD10 |
I34 |
Nonrheumatic mitral valve disorders |
| 40002 |
Contributory (secondary) causes of death: ICD10 |
I34 |
Nonrheumatic mitral valve disorders |
| 42040 |
GP clinical event records |
G114.00 |
Ruptured mitral valve cusp |
| 42040 |
GP clinical event records |
G11..00 |
Mitral valve diseases |
| 42040 |
GP clinical event records |
G11z.00 |
Mitral valve disease NOS |
| 42040 |
GP clinical event records |
G540000 |
Mitral incompetence, non-rheumatic |
| 42040 |
GP clinical event records |
G540100 |
Mitral incompetence, cause unspecified |
| 42040 |
GP clinical event records |
G540200 |
Mitral valve prolapse |
| 42040 |
GP clinical event records |
G540300 |
Mitral valve leaf prolapse |
| 42040 |
GP clinical event records |
G540.00 |
Mitral valve incompetence |
| 42040 |
GP clinical event records |
G540.12 |
Mitral valve insufficiency |
| 42040 |
GP clinical event records |
G540.14 |
Mitral valve regurgitation |
| 42040 |
GP clinical event records |
G540.15 |
Mitral valve prolapse |
| 42040 |
GP clinical event records |
G540.16 |
Mitral regurgitation |
| 42040 |
GP clinical event records |
G540z00 |
Mitral valve disorders NOS |
| 42040 |
GP clinical event records |
Gyu1000 |
[X]Other mitral valve diseases |
| 42040 |
GP clinical event records |
Gyu5500 |
[X]Other nonrheumatic mitral valve disorders |
| 42040 |
GP clinical event records |
X200u |
Mitral valve prolapse |