Metadata

Name Osteoarthritis (excl spine) (OA)
Category Musculoskeletal
Sex
Adult Yes
UUID 7fdc22a0-b334-4190-8dfa-63ae41e5aad4
Definition A progressive, degenerative joint disease, the most common form of arthritis, especially in older persons. The disease is thought to result not from the aging process but from biochemical changes and biomechanical stresses affecting articular cartilage. In the foreign literature it is often called osteoarthrosis deformans.

Ontologies

Disease Ontology (DOID) DOID_8398
GWAS Catalogue EFO_0002506
MeSH D010003
SNOMED-CT 396275006
FinnGen M13_ARTHROSIS

Key Summary Statistics

Cases from any source

Total 126211
Female (%) 75084 (59%)
Male (%) 51127 (41%)

Year first recorded

OA year of first event

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Cross-sourced OA cases

Incidence & prevalence

Sex and age-stratified incidence and prevalence of OA

Baseline prevalence stratified by sex

Female 1691.42 (1666.19,1716.65)
Male 1367.59 (1342.4,1392.79)

Incidence stratified by sex

Female 148.21 (144.66,151.77)
Male 122.46 (119.01,125.92)

Incidence stratified by age

Ages 40-44 49.05 (44.6,53.51)
Ages 45-49 75.81 (70.97,80.65)
Ages 50-54 117.12 (111.41,122.84)
Ages 55-59 145.03 (139.04,151.03)
Ages 60-64 174.7 (168.82,180.58)
Ages 65-69 205.78 (198.18,213.37)

Period prevalence

Methods

Comparison with general population

Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)

CALIBER and UKB OA prevalence comparison for multiple age groups

Population Ages 40-49 Ages 50-59 Ages 60-69
UK Biobank 618 (595,643) 1421 (1392,1450) 2540 (2507,2573)
CALIBER 586 (580,593) 1561 (1549, 2868 (2851,

Stratified by age and Townsend deprivation status

Deprivation status Ages 40-49 Ages 50-59 Ages 60-69
Least deprived 559(505,616) 1307(1246,1370) 2350(2283,2420)
Low 612(556,673) 1309(1248,1373) 2430(2361,2499)
Medium 593(539,650) 1376(1313,1441) 2543(2472,2616)
High 592(543,645) 1457(1393,1523) 2594(2518,2671)
Most deprived 711(661,764) 1646(1578,1715) 2849(2766,2933)

Stratified by age and country

Country Ages 40-49 Ages 50-59 Ages 60-69
England 609(583,637) 1386(1354,1418) 2479(2443,2515)
Scotland 547(484,616) 1353(1277,1431) 2469(2376,2565)
Wales 841(740,952) 1881(1766,2001) 3301(3167,3439)

Risk factors analysis

‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.

Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method

N=153969, Events=129

Factor Level Hazard Ratio P value
BMI overweight 1.18 (0.74, 1.86) 0.489
BMI obese 1.91 (1.2, 3.06) 0.00685
BMI underweight 0 (0, Inf) 0.995
smoking previous 1.29 (0.88, 1.87) 0.189
smoking current 1.41 (0.81, 2.45) 0.23
hypertension yes 1.93 (1.34, 2.77) 0.000403

Risk factors analysis forest plot

Genetic correlation

Genetic correlation (rg) P value
0.65 2.13e-25

Published study: arcOGEN (2012)

Definition

UK Biobank field id Description Code Value
20002 Non-cancer illness code, self-reported 1465 osteoarthritis
20004 Operation code 1318 hip replacement/revision
20004 Operation code 1319 knee replacement/revision
41202 Diagnoses - main ICD10 M15 Polyarthrosis
41202 Diagnoses - main ICD10 M16 Coxarthrosis [arthrosis of hip]
41202 Diagnoses - main ICD10 M17 Gonarthrosis [arthrosis of knee]
41202 Diagnoses - main ICD10 M18 Arthrosis of first carpometacarpal joint
41202 Diagnoses - main ICD10 M19 Other arthrosis
41204 Diagnoses - secondary ICD10 M15 Polyarthrosis
41204 Diagnoses - secondary ICD10 M16 Coxarthrosis [arthrosis of hip]
41204 Diagnoses - secondary ICD10 M17 Gonarthrosis [arthrosis of knee]
41204 Diagnoses - secondary ICD10 M18 Arthrosis of first carpometacarpal joint
41204 Diagnoses - secondary ICD10 M19 Other arthrosis
40001 Underlying (primary) cause of death: ICD10 M15 Polyarthrosis
40001 Underlying (primary) cause of death: ICD10 M16 Coxarthrosis [arthrosis of hip]
40001 Underlying (primary) cause of death: ICD10 M17 Gonarthrosis [arthrosis of knee]
40001 Underlying (primary) cause of death: ICD10 M18 Arthrosis of first carpometacarpal joint
40001 Underlying (primary) cause of death: ICD10 M19 Other arthrosis
40002 Contributory (secondary) causes of death: ICD10 M15 Polyarthrosis
40002 Contributory (secondary) causes of death: ICD10 M16 Coxarthrosis [arthrosis of hip]
40002 Contributory (secondary) causes of death: ICD10 M17 Gonarthrosis [arthrosis of knee]
40002 Contributory (secondary) causes of death: ICD10 M18 Arthrosis of first carpometacarpal joint
40002 Contributory (secondary) causes of death: ICD10 M19 Other arthrosis
42040 GP clinical event records 14G2.00 H/O: osteoarthritis
42040 GP clinical event records 2G26.00 O/E - hands - Heberden’s nodes
42040 GP clinical event records 7P20400 Delivery of rehabilitation for osteoarthritis
42040 GP clinical event records N050000 Generalised osteoarthritis of unspecified site
42040 GP clinical event records N050100 Generalised osteoarthritis of the hand
42040 GP clinical event records N050111 Heberdens’ nodes
42040 GP clinical event records N050112 Bouchards’ nodes
42040 GP clinical event records N050200 Generalised osteoarthritis of multiple sites
42040 GP clinical event records N050300 Bouchard’s nodes with arthropathy
42040 GP clinical event records N050400 Primary generalized osteoarthrosis
42040 GP clinical event records N050500 Secondary multiple arthrosis
42040 GP clinical event records N050600 Erosive osteoarthrosis
42040 GP clinical event records N050700 Heberden’s nodes with arthropathy
42040 GP clinical event records N050.00 Generalised osteoarthritis - OA
42040 GP clinical event records N050z00 Generalised osteoarthritis NOS
42040 GP clinical event records N051000 Localised, primary osteoarthritis of unspecified site
42040 GP clinical event records N051100 Localised, primary osteoarthritis of the shoulder region
42040 GP clinical event records N051200 Localised, primary osteoarthritis of the upper arm
42040 GP clinical event records N051300 Localised, primary osteoarthritis of the forearm
42040 GP clinical event records N051400 Localised, primary osteoarthritis of the hand
42040 GP clinical event records N051500 Localised, primary osteoarthritis of the pelvic region/thigh
42040 GP clinical event records N051600 Localised, primary osteoarthritis of the lower leg
42040 GP clinical event records N051700 Localised, primary osteoarthritis of the ankle and foot
42040 GP clinical event records N051800 Localised, primary osteoarthritis of other specified site
42040 GP clinical event records N051900 Primary coxarthrosis, bilateral
42040 GP clinical event records N051A00 Coxarthrosis resulting from dysplasia, bilateral
42040 GP clinical event records N051B00 Primary gonarthrosis, bilateral
42040 GP clinical event records N051C00 Primary arthrosis of first carpometacarpal joints, bilateral
42040 GP clinical event records N051D00 Localised, primary osteoarthritis of the wrist
42040 GP clinical event records N051E00 Localised, primary osteoarthritis of toe
42040 GP clinical event records N051F00 Localised, primary osteoarthritis of elbow
42040 GP clinical event records N051G00 Osteoarthritis of spinal facet joint
42040 GP clinical event records N051.00 Localised, primary osteoarthritis
42040 GP clinical event records N051z00 Localised, primary osteoarthritis NOS
42040 GP clinical event records N052000 Localised, secondary osteoarthritis of unspecified site
42040 GP clinical event records N052100 Localised, secondary osteoarthritis of the shoulder region
42040 GP clinical event records N052200 Localised, secondary osteoarthritis of the upper arm
42040 GP clinical event records N052300 Localised, secondary osteoarthritis of the forearm
42040 GP clinical event records N052400 Localised, secondary osteoarthritis of the hand
42040 GP clinical event records N052500 Localised, secondary osteoarthritis of pelvic region/thigh
42040 GP clinical event records N052511 Coxae malum senilis
42040 GP clinical event records N052600 Localised, secondary osteoarthritis of the lower leg
42040 GP clinical event records N052700 Localised, secondary osteoarthritis of the ankle and foot
42040 GP clinical event records N052800 Localised, secondary osteoarthritis of other specified site
42040 GP clinical event records N052.00 Localised, secondary osteoarthritis
42040 GP clinical event records N052z00 Localised, secondary osteoarthritis NOS
42040 GP clinical event records N053000 Localised osteoarthritis, unspecified, of unspecified site
42040 GP clinical event records N053100 Localised osteoarthritis, unspecified, of shoulder region
42040 GP clinical event records N053200 Localised osteoarthritis, unspecified, of the upper arm
42040 GP clinical event records N053300 Localised osteoarthritis, unspecified, of the forearm
42040 GP clinical event records N053400 Localised osteoarthritis, unspecified, of the hand
42040 GP clinical event records N053500 Localised osteoarthritis, unspecified, pelvic region/thigh
42040 GP clinical event records N053512 Hip osteoarthitis NOS
42040 GP clinical event records N053600 Localised osteoarthritis, unspecified, of the lower leg
42040 GP clinical event records N053611 Patellofemoral osteoarthritis
42040 GP clinical event records N053700 Localised osteoarthritis, unspecified, of the ankle and foot
42040 GP clinical event records N053800 Localised osteoarthritis, unspecified, of other spec site
42040 GP clinical event records N053900 Arthrosis of first carpometacarpal joint, unspecified
42040 GP clinical event records N053.00 Localised osteoarthritis, unspecified
42040 GP clinical event records N053z00 Localised osteoarthritis, unspecified, NOS
42040 GP clinical event records N054000 Oligoarticular osteoarthritis, unspec, of unspecified sites
42040 GP clinical event records N054100 Oligoarticular osteoarthritis, unspecified, of shoulder
42040 GP clinical event records N054200 Oligoarticular osteoarthritis, unspecified, of upper arm
42040 GP clinical event records N054400 Oligoarticular osteoarthritis, unspecified, of hand
42040 GP clinical event records N054500 Oligoarticular osteoarthritis, unspecified, of pelvis/thigh
42040 GP clinical event records N054600 Oligoarticular osteoarthritis, unspecified, of lower leg
42040 GP clinical event records N054700 Oligoarticular osteoarthritis, unspecified, of ankle/foot
42040 GP clinical event records N054800 Oligoarticular osteoarthritis, unspecified, other spec sites
42040 GP clinical event records N054900 Oligoarticular osteoarthritis, unspecified, multiple sites
42040 GP clinical event records N054.00 Oligoarticular osteoarthritis, unspecified
42040 GP clinical event records N054z00 Osteoarthritis of more than one site, unspecified, NOS
42040 GP clinical event records N05..00 Osteoarthritis and allied disorders
42040 GP clinical event records N05..11 Osteoarthritis
42040 GP clinical event records N05z000 Osteoarthritis NOS, of unspecified site
42040 GP clinical event records N05z100 Osteoarthritis NOS, of shoulder region
42040 GP clinical event records N05z400 Osteoarthritis NOS, of the hand
42040 GP clinical event records N05z411 Finger osteoarthritis NOS
42040 GP clinical event records N05z412 Thumb osteoarthritis NOS
42040 GP clinical event records N05z500 Osteoarthritis NOS, pelvic region/thigh
42040 GP clinical event records N05z511 Hip osteoarthritis NOS
42040 GP clinical event records N05z600 Osteoarthritis NOS, of the lower leg
42040 GP clinical event records N05z611 Knee osteoarthritis NOS
42040 GP clinical event records N05z700 Osteoarthritis NOS, of ankle and foot
42040 GP clinical event records N05z711 Ankle osteoarthritis NOS
42040 GP clinical event records N05z712 Foot osteoarthritis NOS
42040 GP clinical event records N05z713 Toe osteoarthritis NOS
42040 GP clinical event records N05z800 Osteoarthritis NOS, other specified site
42040 GP clinical event records N05z900 Osteoarthritis NOS, of shoulder
42040 GP clinical event records N05zA00 Osteoarthritis NOS, of sternoclavicular joint
42040 GP clinical event records N05zB00 Osteoarthritis NOS, of acromioclavicular joint
42040 GP clinical event records N05zC00 Osteoarthritis NOS, of elbow
42040 GP clinical event records N05zD00 Osteoarthritis NOS, of distal radio-ulnar joint
42040 GP clinical event records N05zE00 Osteoarthritis NOS, of wrist
42040 GP clinical event records N05zF00 Osteoarthritis NOS, of MCP joint
42040 GP clinical event records N05zG00 Osteoarthritis NOS, of PIP joint of finger
42040 GP clinical event records N05zH00 Osteoarthritis NOS, of DIP joint of finger
42040 GP clinical event records N05zJ00 Osteoarthritis NOS, of hip
42040 GP clinical event records N05zK00 Osteoarthritis NOS, of sacro-iliac joint
42040 GP clinical event records N05zL00 Osteoarthritis NOS, of knee
42040 GP clinical event records N05zM00 Osteoarthritis NOS, of tibio-fibular joint
42040 GP clinical event records N05z.00 Osteoarthritis NOS
42040 GP clinical event records N05z.11 Joint degeneration
42040 GP clinical event records N05zN00 Osteoarthritis NOS, of ankle
42040 GP clinical event records N05zP00 Osteoarthritis NOS, of subtalar joint
42040 GP clinical event records N05zQ00 Osteoarthritis NOS, of talonavicular joint
42040 GP clinical event records N05zR00 Osteoarthritis NOS, of other tarsal joint
42040 GP clinical event records N05zS00 Osteoarthritis NOS, of 1st MTP joint
42040 GP clinical event records N05zT00 Osteoarthritis NOS, of lesser MTP joint
42040 GP clinical event records N05zU00 Osteoarthritis NOS, of IP joint of toe
42040 GP clinical event records N05zz00 Osteoarthritis NOS
42040 GP clinical event records Nyu2000 [X]Other polyarthrosis
42040 GP clinical event records Nyu2100 [X]Other primary coxarthrosis
42040 GP clinical event records Nyu2200 [X]Other dysplastic coxarthrosis
42040 GP clinical event records Nyu2400 [X]Other secondary coxarthrosis, bilateral
42040 GP clinical event records Nyu2500 [X]Other primary gonarthrosis
42040 GP clinical event records Nyu2511 [X] Unilateral primary gonarthrosis
42040 GP clinical event records Nyu2700 [X]Other secondary gonarthrosis, bilateral
42040 GP clinical event records Nyu2800 [X]Other secondary gonarthrosis
42040 GP clinical event records Nyu2811 [X] Unilateral secondary gonarthrosis
42040 GP clinical event records Nyu2900 [X]Other primary arthrosis of first carpometacarpal joint
42040 GP clinical event records Nyu2D00 [X]Other specified arthrosis
42040 GP clinical event records Nyu2E00 [X]Other secondary coxarthrosis
42040 GP clinical event records Nyu2E11 [X] Unilateral secondary coxarthrosis
42040 GP clinical event records Nyu2.00 [X]Arthrosis
42040 GP clinical event records XE1DW Generalised osteoarthritis of the hand
42040 GP clinical event records XE1GU [X]Other secondary gonarthrosis
42040 GP clinical event records XE1Dd Osteoarthritis NOS, of the hand
42040 GP clinical event records XE1Da Osteoarthritis NOS
42040 GP clinical event records XaLsk Delivery of rehabilitation for osteoarthritis
42040 GP clinical event records X703A Osteoarthritis of spinal facet joint
42040 GP clinical event records XaEGf Localised, primary osteoarthritis of elbow
42040 GP clinical event records XE1De Osteoarthritis NOS, pelvic region/thigh
42040 GP clinical event records XE1DX Localised, secondary osteoarthritis of the pelvic region and thigh
42040 GP clinical event records XE1Dg Osteoarthritis NOS, of ankle and foot
42040 GP clinical event records XE1GT [X]Other primary gonarthrosis
42040 GP clinical event records XaEGd Localised, primary osteoarthritis of the wrist
42040 GP clinical event records XaEGe Localised, primary osteoarthritis of toe
42040 GP clinical event records XE1Df Osteoarthritis NOS, of the lower leg
42040 GP clinical event records XE1DY Localised osteoarthritis, unspecified, of the pelvic region and thigh
42040 GP clinical event records XE1DZ Localised osteoarthritis, unspecified, of the lower leg
42040 GP clinical event records XE1Da Osteoarthritis NOS
42040 GP clinical event records XE1GV [X]Other secondary coxarthrosis