Obesity

Metadata

Name	Obesity (obesity)
Category	Endocrine
Sex
Adult	Yes
UUID	0496d30a-ccf0-4b19-8c15-4ef8762d5974
Definition	Obesity is a complex disease involving an excessive amount of body fat.

Ontologies

Disease Ontology (DOID)	DOID_50957
GWAS Catalogue	EFO_0001073
MeSH	D009765
SNOMED-CT	414916001
FinnGen	E4_OBESITY

Key Summary Statistics

Cases from any source

Total	50234
Female (%)	27810 (55%)
Male (%)	22424 (45%)

Year first recorded

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Incidence & prevalence

Baseline prevalence stratified by sex

Female	688.76 (671.72,705.8)
Male	581.25 (564.09,598.41)

Incidence stratified by sex

Female	61.4 (59.27,63.54)
Male	64.85 (62.46,67.24)

Incidence stratified by age

Ages 40-44	56.57 (51.73,61.41)
Ages 45-49	60.66 (56.34,64.98)
Ages 50-54	65.15 (60.98,69.31)
Ages 55-59	67.21 (63.36,71.05)
Ages 60-64	62.35 (59.17,65.53)
Ages 65-69	62.89 (59.24,66.55)

Period prevalence

Methods

Comparison with general population

Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)

Population	Ages 40-49	Ages 50-59	Ages 60-69
UK Biobank	844 (817,873)	1052 (1028,1077)	1107 (1086,1129)
CALIBER	2154 (2142,	2639 (2623,	2969 (2952,

Stratified by age and Townsend deprivation status

Deprivation status	Ages 40-49	Ages 50-59	Ages 60-69
Least deprived	541(489,598)	744(697,792)	828(788,869)
Low	630(574,691)	845(796,897)	923(881,967)
Medium	752(692,816)	966(913,1020)	1029(984,1076)
High	846(787,908)	1097(1042,1155)	1194(1143,1247)
Most deprived	1270(1203,1340)	1582(1516,1651)	1679(1616,1744)

Stratified by age and country

Country	Ages 40-49	Ages 50-59	Ages 60-69
England	791(761,822)	960(933,987)	1012(989,1035)
Scotland	1112(1022,1209)	1444(1365,1526)	1634(1558,1713)
Wales	994(885,1113)	1304(1209,1405)	1306(1222,1394)

Risk factors analysis

‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.

Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method

N=144148, Events=6009

Factor	Level	Hazard Ratio	P value
BMI	overweight	11.38 (9.13, 14.19)	5.4799999999999994e-104
BMI	obese	105.81 (85.37, 131.15)	0.0
BMI	underweight	0.72 (0.1, 5.2)	0.748
smoking	previous	1.24 (1.17, 1.31)	3.31e-14
smoking	current	1.26 (1.16, 1.36)	8.24e-08
hypertension	yes	2.26 (2.13, 2.39)	1.3899999999999998e-180

Definition

UK Biobank field id	Description	Code	Value
41202	Diagnoses - main ICD10	E66	Obesity
41204	Diagnoses - secondary ICD10	E66	Obesity
41200	Operative procedures - main OPCS4	G282	G282
41200	Operative procedures - main OPCS4	G283	G283
41200	Operative procedures - main OPCS4	G288	G288
41200	Operative procedures - main OPCS4	G289	G289
41200	Operative procedures - main OPCS4	G301	G301
41200	Operative procedures - main OPCS4	G302	G302
41200	Operative procedures - main OPCS4	G303	G303
41200	Operative procedures - main OPCS4	G304	G304
41200	Operative procedures - main OPCS4	G308	G308
41200	Operative procedures - main OPCS4	G309	G309
41200	Operative procedures - main OPCS4	G321	G321
41200	Operative procedures - main OPCS4	G328	G328
41200	Operative procedures - main OPCS4	G329	G329
41200	Operative procedures - main OPCS4	G611	G611
41200	Operative procedures - main OPCS4	G612	G612
41200	Operative procedures - main OPCS4	G613	G613
41200	Operative procedures - main OPCS4	G618	G618
41200	Operative procedures - main OPCS4	G619	G619
41210	Operative procedures - secondary OPCS4	G282	G282
41210	Operative procedures - secondary OPCS4	G283	G283
41210	Operative procedures - secondary OPCS4	G288	G288
41210	Operative procedures - secondary OPCS4	G289	G289
41210	Operative procedures - secondary OPCS4	G301	G301
41210	Operative procedures - secondary OPCS4	G302	G302
41210	Operative procedures - secondary OPCS4	G303	G303
41210	Operative procedures - secondary OPCS4	G304	G304
41210	Operative procedures - secondary OPCS4	G308	G308
41210	Operative procedures - secondary OPCS4	G309	G309
41210	Operative procedures - secondary OPCS4	G321	G321
41210	Operative procedures - secondary OPCS4	G328	G328
41210	Operative procedures - secondary OPCS4	G329	G329
41210	Operative procedures - secondary OPCS4	G611	G611
41210	Operative procedures - secondary OPCS4	G612	G612
41210	Operative procedures - secondary OPCS4	G613	G613
41210	Operative procedures - secondary OPCS4	G618	G618
41210	Operative procedures - secondary OPCS4	G619	G619
40001	Underlying (primary) cause of death: ICD10	E66	Obesity
40002	Contributory (secondary) causes of death: ICD10	E66	Obesity
42040	GP clinical event records	1444.00	H/O: obesity
42040	GP clinical event records	212Q.00	Obesity resolved
42040	GP clinical event records	222A.00	O/E - obese
42040	GP clinical event records	22A5.11	O/E - obese
42040	GP clinical event records	22K5.00	Body mass index 30+ - obesity
42040	GP clinical event records	22K7.00	Body mass index 40+ - severely obese
42040	GP clinical event records	66C1.00	Initial obesity assessment
42040	GP clinical event records	66C2.00	Follow-up obesity assessment
42040	GP clinical event records	66C4.00	Has seen dietician - obesity
42040	GP clinical event records	66C5.00	Treatment of obesity changed
42040	GP clinical event records	66C6.00	Treatment of obesity started
42040	GP clinical event records	66C..00	Obesity monitoring
42040	GP clinical event records	66CE.00	Reason for obesity therapy - occupational
42040	GP clinical event records	66CZ.00	Obesity monitoring NOS
42040	GP clinical event records	7633.00	Bypass of jejunum
42040	GP clinical event records	7611400.0	Sleeve gastrectomy and duodenal switch
42040	GP clinical event records	7611500.0	Sleeve gastrectomy NEC
42040	GP clinical event records	7611600.0	Laparoscopic sleeve gastrectomy
42040	GP clinical event records	7613100.0	Partitioning of stomach
42040	GP clinical event records	7613111.0	Mason vertical banded gastroplasty
42040	GP clinical event records	7613200.0	Laparoscopic adjustable gastric banding
42040	GP clinical event records	7613300.0	Partitioning of stomach using band
42040	GP clinical event records	7613400.0	Partitioning of stomach using staples
42040	GP clinical event records	7613500.0	Partitioning of stomach NEC
42040	GP clinical event records	7613600.0	Maintenance of gastric band
42040	GP clinical event records	7614100.0	Bypass of stomach by anastomosis of stomach to duodenum
42040	GP clinical event records	7615000.0	Bypass stomach by anastomosis stomach to transposed jejunum
42040	GP clinical event records	7616000.0	Bypass of stomach by anastomosis of stomach to jejunum NEC
42040	GP clinical event records	7616013.0	Mason high gastric bypass
42040	GP clinical event records	7616015.0	Printer high gastric bypass
42040	GP clinical event records	7616600.0	Laparoscopic gastric bypass
42040	GP clinical event records	7633000.0	Bypass of jejunum by anastomosis of jejunum to jejunum
42040	GP clinical event records	7633100.0	Bypass of jejunum by anastomosis of jejunum to ileum
42040	GP clinical event records	7633200.0	Bypass of jejunum by anastomosis of jejunum to colon
42040	GP clinical event records	7642500.0	Duodenal switch
42040	GP clinical event records	761A500	Removal of gastric band
42040	GP clinical event records	7633y00	Other specified bypass of jejunum
42040	GP clinical event records	7633z00	Bypass of jejunum NOS
42040	GP clinical event records	9OK1.00	Attends obesity monitoring
42040	GP clinical event records	9OK2.00	Refuses obesity monitoring
42040	GP clinical event records	9OK3.00	Obesity monitoring default
42040	GP clinical event records	9OK4.00	Obesity monitoring 1st letter
42040	GP clinical event records	9OK5.00	Obesity monitoring 2nd letter
42040	GP clinical event records	9OK6.00	Obesity monitoring 3rd letter
42040	GP clinical event records	9OK7.00	Obesity monitoring verbal inv.
42040	GP clinical event records	9OK8.00	Obesity monitor phone invite
42040	GP clinical event records	9OK..00	Obesity monitoring admin.
42040	GP clinical event records	9OK..11	Obesity clinic administration
42040	GP clinical event records	9OKA.00	Obesity monitoring check done
42040	GP clinical event records	9OKZ.00	Obesity monitoring admin.NOS
42040	GP clinical event records	C380000	Obesity due to excess calories
42040	GP clinical event records	C380100	Drug-induced obesity
42040	GP clinical event records	C380200	Extreme obesity with alveolar hypoventilation
42040	GP clinical event records	C380300	Morbid obesity
42040	GP clinical event records	C380400	Central obesity
42040	GP clinical event records	C380500	Generalised obesity
42040	GP clinical event records	C380600	Adult-onset obesity
42040	GP clinical event records	C380700	Lifelong obesity
42040	GP clinical event records	C380.00	Obesity
42040	GP clinical event records	C38..00	Obesity and other hyperalimentation
42040	GP clinical event records	C38y000	Pickwickian syndrome
42040	GP clinical event records	C38y011	Obesity hypoventilation syndrome
42040	GP clinical event records	C38y.11	Pickwickian syndrome
42040	GP clinical event records	C38z000	Simple obesity NOS
42040	GP clinical event records	C38z.00	Obesity and other hyperalimentation NOS
42040	GP clinical event records	Cyu7000	[X]Other obesity
42040	GP clinical event records	Cyu7.00	[X]Obesity and other hyperalimentation
42040	GP clinical event records	ZC2CM00	Dietary advice for obesity
42040	GP clinical event records	ZV45P00	[V]Presence of gastric bypass
42040	GP clinical event records	ZV65319	[V]Dietary counselling in obesity
42040	GP clinical event records	XE2Nc	Obesity monitoring admin.
42040	GP clinical event records	XE11t	Other hyperalimentation
42040	GP clinical event records	XE1T6	Obesity monitoring
42040	GP clinical event records	XaLd9	Partitioning of stomach using band
42040	GP clinical event records	XaLd8	Sleeve gastrectomy NEC
42040	GP clinical event records	XE0Cg	Partitioning of stomach
42040	GP clinical event records	XSCIZ	Adult-onset obesity
42040	GP clinical event records	X40YQ	Morbid obesity
42040	GP clinical event records	XaLdW	Duodenal switch
42040	GP clinical event records	XaBM0	Simple obesity NOS
42040	GP clinical event records	XaPp5	[V]Presence of gastric bypass
42040	GP clinical event records	XaK95	Laparoscopic adjustable gastric banding
42040	GP clinical event records	X76BU	Central obesity
42040	GP clinical event records	XaLdA	Partitioning of stomach using staples
42040	GP clinical event records	X40YR	Pickwickian syndrome
42040	GP clinical event records	XaJJH	Body mass index 40+ - severely obese
42040	GP clinical event records	X40YO	Generalised obesity
42040	GP clinical event records	XaOi9	Laparoscopic gastric bypass
42040	GP clinical event records	XE0Ch	Bypass of stomach by anastomosis of stomach to duodenum
42040	GP clinical event records	XE0Cy	Bypass of jejunum by anastomosis of jejunum to colon
42040	GP clinical event records	XaPpT	Maintenance of gastric band
42040	GP clinical event records	XaKko	Obesity resolved
42040	GP clinical event records	XE0Ci	Bypass of stomach by anastomosis of stomach to jejunum NEC
42040	GP clinical event records	XaLd7	Sleeve gastrectomy and duodenal switch
42040	GP clinical event records	XaMHV	Partitioning of stomach NEC
42040	GP clinical event records	XaMgn	Laparoscopic sleeve gastrectomy
42040	GP clinical event records	XaLdH	Removal of gastric band
42040	GP clinical event records	XSCIX	Lifelong obesity