Metadata
| Name | Oesophagitis and oesophageal ulcer (oesoph_ulc) |
| Category | Digestive |
| Sex | |
| Adult | Yes |
| UUID | 515f0924-1cc7-4fe9-b389-6970a2dddfbd |
| Definition | Inflammation, acute or chronic, of the esophagus caused by bacteria, chemicals, or trauma. |
Ontologies
| Disease Ontology (DOID) | DOID_11963 |
| GWAS Catalogue | HP_0100633 |
| MeSH | D004941 |
| SNOMED-CT | 16761005 |
| FinnGen | K11_OESITIS |
Key Summary Statistics
Cases from any source
| Total | 41498 |
| Female (%) | 20433 (49%) |
| Male (%) | 21065 (51%) |
Year first recorded
Cases linked in all UK Biobank sources
Cross-source concordance
Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.
Incidence & prevalence
Baseline prevalence stratified by sex
| Female | 430.84 (417.18,444.51) |
| Male | 554.09 (537.32,570.87) |
Incidence stratified by sex
| Female | 41.29 (39.57,43.01) |
| Male | 50.0 (47.92,52.09) |
Incidence stratified by age
| Ages 40-44 | 22.77 (19.76,25.78) |
| Ages 45-49 | 30.89 (27.86,33.92) |
| Ages 50-54 | 37.55 (34.45,40.65) |
| Ages 55-59 | 45.93 (42.8,49.05) |
| Ages 60-64 | 54.73 (51.78,57.68) |
| Ages 65-69 | 60.41 (56.84,63.99) |
Period prevalence
Methods
Comparison with general population
Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)
| Population | Ages 40-49 | Ages 50-59 | Ages 60-69 |
| UK Biobank | 452 (431,473) | 708 (687,729) | 971 (951,991) |
| CALIBER | 536 (530,542) | 810 (802,819) | 1115 (1104, |
Stratified by age and Townsend deprivation status
| Deprivation status | Ages 40-49 | Ages 50-59 | Ages 60-69 |
| Least deprived | 396(351,445) | 617(575,662) | 883(841,926) |
| Low | 378(333,426) | 658(614,704) | 909(867,953) |
| Medium | 439(393,490) | 697(651,744) | 968(924,1014) |
| High | 447(403,493) | 702(657,749) | 1009(961,1058) |
| Most deprived | 549(505,597) | 859(810,910) | 1120(1069,1174) |
Stratified by age and country
| Country | Ages 40-49 | Ages 50-59 | Ages 60-69 |
| England | 443(420,466) | 716(693,739) | 975(952,998) |
| Scotland | 370(317,428) | 595(544,649) | 831(776,888) |
| Wales | 690(599,791) | 819(743,900) | 1157(1078,1240) |
Risk factors analysis
‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.
Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method
N=153646, Events=402
| Factor | Level | Hazard Ratio | P value |
| BMI | overweight | 1.07 (0.82, 1.39) | 0.637 |
| BMI | obese | 2.13 (1.65, 2.77) | 1.06e-08 |
| BMI | underweight | 0 (0, Inf) | 0.986 |
| smoking | previous | 1.48 (1.19, 1.85) | 0.000498 |
| smoking | current | 2.47 (1.87, 3.26) | 1.43e-10 |
| hypertension | yes | 2.21 (1.8, 2.72) | 5.76e-14 |
Definition
| UK Biobank field id | Description | Code | Value |
|---|---|---|---|
| 41202 | Diagnoses - main ICD10 | K20 | Oesophagitis |
| 41202 | Diagnoses - main ICD10 | K21.0 | Gastro-oesophageal reflux disease with oesophagitis |
| 41202 | Diagnoses - main ICD10 | K22.1 | Ulcer of oesophagus |
| 41204 | Diagnoses - secondary ICD10 | K20 | Oesophagitis |
| 41204 | Diagnoses - secondary ICD10 | K21.0 | Gastro-oesophageal reflux disease with oesophagitis |
| 41204 | Diagnoses - secondary ICD10 | K22.1 | Ulcer of oesophagus |
| 40001 | Underlying (primary) cause of death: ICD10 | K20 | Oesophagitis |
| 40001 | Underlying (primary) cause of death: ICD10 | K21.0 | Gastro-oesophageal reflux disease with oesophagitis |
| 40001 | Underlying (primary) cause of death: ICD10 | K22.1 | Ulcer of oesophagus |
| 40002 | Contributory (secondary) causes of death: ICD10 | K20 | Oesophagitis |
| 40002 | Contributory (secondary) causes of death: ICD10 | K21.0 | Gastro-oesophageal reflux disease with oesophagitis |
| 40002 | Contributory (secondary) causes of death: ICD10 | K22.1 | Ulcer of oesophagus |
| 42040 | GP clinical event records | J101000 | Abscess of oesophagus |
| 42040 | GP clinical event records | J101.00 | Oesophagitis |
| 42040 | GP clinical event records | J101100 | Reflux oesophagitis |
| 42040 | GP clinical event records | J101112 | Gastro-oesophageal reflux with oesophagitis |
| 42040 | GP clinical event records | J101113 | Oesophageal reflux with oesophagitis |
| 42040 | GP clinical event records | J101114 | Peptic oesophagitis |
| 42040 | GP clinical event records | J101115 | Regurgitant oesophagitis |
| 42040 | GP clinical event records | J101200 | Chemical oesophagitis |
| 42040 | GP clinical event records | J101300 | Postoperative oesophagitis |
| 42040 | GP clinical event records | J101400 | Gangrenous oesophagitis |
| 42040 | GP clinical event records | J101500 | Phlegmonous oesophagitis |
| 42040 | GP clinical event records | J101600 | Ulcerative oesophagitis |
| 42040 | GP clinical event records | J101y00 | Other specified oesophagitis |
| 42040 | GP clinical event records | J101z00 | Oesophagitis NOS |
| 42040 | GP clinical event records | J102000 | Peptic ulcer of oesophagus |
| 42040 | GP clinical event records | J102.00 | Ulcer of oesophagus |
| 42040 | GP clinical event records | J102100 | Fungal ulcer of oesophagus |
| 42040 | GP clinical event records | J102200 | Oesophageal ulcer due to aspirin |
| 42040 | GP clinical event records | J102300 | Oesophageal ulcer due to chemicals |
| 42040 | GP clinical event records | J102400 | Oesophageal ulcer due to medicines |
| 42040 | GP clinical event records | J102z00 | Ulcer of oesophagus NOS |
| 42040 | GP clinical event records | J10y300 | Oesophageal erosions |