Osteoporosis

Metadata

Name	Osteoporosis (osteoporosis)
Category	Musculoskeletal
Sex
Adult	Yes
UUID	0f4100db-b33f-491e-b9d9-a5e985456369
Definition	A condition of reduced bone mass, with decreased cortical thickness and a decrease in the number and size of the trabeculae of cancellous bone (but normal chemical composition), resulting in increased fracture incidence.

Ontologies

Disease Ontology (DOID)	DOID_11476
GWAS Catalogue	EFO_0003882
MeSH	D010024
SNOMED-CT	64859006
FinnGen	M13_OSTEOPOROSIS

Key Summary Statistics

Cases from any source

Total	28657
Female (%)	23997 (84%)
Male (%)	4660 (16%)

Year first recorded

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Incidence & prevalence

Baseline prevalence stratified by sex

Female	447.93 (434.01,461.85)
Male	93.8 (86.73,100.86)

Incidence stratified by sex

Female	69.25 (67.01,71.49)
Male	12.55 (11.53,13.56)

Incidence stratified by age

Ages 40-44	5.66 (4.18,7.14)
Ages 45-49	15.15 (13.06,17.24)
Ages 50-54	30.04 (27.31,32.77)
Ages 55-59	45.02 (41.96,48.08)
Ages 60-64	57.02 (54.04,60.01)
Ages 65-69	71.61 (67.74,75.48)

Period prevalence

Methods

Comparison with general population

Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)

Population	Ages 40-49	Ages 50-59	Ages 60-69
UK Biobank	99 (90,109)	316 (303,329)	706 (689,723)
CALIBER	61 (59,63)	228 (224,233)	569 (561,576)

Stratified by age and Townsend deprivation status

Deprivation status	Ages 40-49	Ages 50-59	Ages 60-69
Least deprived	86(67,110)	266(240,294)	682(647,719)
Low	87(67,111)	307(279,338)	657(623,693)
Medium	86(67,109)	298(271,328)	692(656,729)
High	94(75,116)	307(279,336)	713(675,753)
Most deprived	130(109,154)	399(366,433)	806(763,850)

Stratified by age and country

Country	Ages 40-49	Ages 50-59	Ages 60-69
England	99(89,110)	307(293,322)	675(657,694)
Scotland	84(61,112)	367(330,408)	852(800,907)
Wales	118(83,163)	320(275,369)	797(734,865)

Risk factors analysis

‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.

Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method

N=153520, Events=195

Factor	Level	Hazard Ratio	P value
BMI	overweight	1.39 (0.98, 1.99)	0.068
BMI	obese	1.63 (1.11, 2.4)	0.0126
BMI	underweight	0 (0, Inf)	0.99
smoking	previous	1.5 (1.1, 2.03)	0.00988
smoking	current	1.45 (0.93, 2.27)	0.0986
hypertension	yes	1.38 (0.98, 1.93)	0.0624

Definition

UK Biobank field id	Description	Code	Value
20002	Non-cancer illness code, self-reported	1309	osteoporosis
41202	Diagnoses - main ICD10	M80	Osteoporosis with pathological fracture
41202	Diagnoses - main ICD10	M81	Osteoporosis without pathological fracture
41202	Diagnoses - main ICD10	M82	Osteoporosis in diseases classified elsewhere
41204	Diagnoses - secondary ICD10	M80	Osteoporosis with pathological fracture
41204	Diagnoses - secondary ICD10	M81	Osteoporosis without pathological fracture
41204	Diagnoses - secondary ICD10	M82	Osteoporosis in diseases classified elsewhere
40001	Underlying (primary) cause of death: ICD10	M80	Osteoporosis with pathological fracture
40001	Underlying (primary) cause of death: ICD10	M81	Osteoporosis without pathological fracture
40001	Underlying (primary) cause of death: ICD10	M82	Osteoporosis in diseases classified elsewhere
40002	Contributory (secondary) causes of death: ICD10	M80	Osteoporosis with pathological fracture
40002	Contributory (secondary) causes of death: ICD10	M81	Osteoporosis without pathological fracture
40002	Contributory (secondary) causes of death: ICD10	M82	Osteoporosis in diseases classified elsewhere
42040	GP clinical event records	14GB.00	History of osteoporosis
42040	GP clinical event records	58EG.00	Hip DXA scan result osteoporotic
42040	GP clinical event records	58EM.00	Lumbar DXA scan result osteoporotic
42040	GP clinical event records	58EV.00	Femoral neck DEXA scan result osteoporotic
42040	GP clinical event records	66a..00	Osteoporosis monitoring
42040	GP clinical event records	9kj0.00	Bone sparing drug treatment offered for osteoporosis - ESA
42040	GP clinical event records	9kj..00	Osteoporosis - enhanced services administration
42040	GP clinical event records	9Od0.00	Attends osteoporosis monitoring
42040	GP clinical event records	9Od2.00	Osteoporosis monitoring default
42040	GP clinical event records	9Od3.00	Osteoporosis monitoring first letter
42040	GP clinical event records	9Od4.00	Osteoporosis monitoring second letter
42040	GP clinical event records	9Od5.00	Osteoporosis monitoring third letter
42040	GP clinical event records	9Od6.00	Osteoporosis monitoring verbal invitation
42040	GP clinical event records	9Od7.00	Osteoporosis monitoring telephone invitation
42040	GP clinical event records	9Od8.00	Osteoporosis monitoring deleted
42040	GP clinical event records	9Od9.00	Osteoporosis monitoring check done
42040	GP clinical event records	9Od..00	Osteoporosis monitoring administration
42040	GP clinical event records	N330000	Osteoporosis, unspecified
42040	GP clinical event records	N330100	Senile osteoporosis
42040	GP clinical event records	N330200	Postmenopausal osteoporosis
42040	GP clinical event records	N330300	Idiopathic osteoporosis
42040	GP clinical event records	N330400	Dissuse osteoporosis
42040	GP clinical event records	N330500	Drug-induced osteoporosis
42040	GP clinical event records	N330600	Postoophorectomy osteoporosis
42040	GP clinical event records	N330700	Postsurgical malabsorption osteoporosis
42040	GP clinical event records	N330A00	Osteoporosis in endocrine disorders
42040	GP clinical event records	N330B00	Vertebral osteoporosis
42040	GP clinical event records	N330C00	Osteoporosis localized to spine
42040	GP clinical event records	N330D00	Osteoporosis due to corticosteroids
42040	GP clinical event records	N330.00	Osteoporosis
42040	GP clinical event records	N330z00	Osteoporosis NOS
42040	GP clinical event records	N331200	Postoophorectomy osteoporosis with pathological fracture
42040	GP clinical event records	N331300	Osteoporosis of disuse with pathological fracture
42040	GP clinical event records	N331400	Postsurgical malabsorption osteoporosis with path fracture
42040	GP clinical event records	N331500	Drug-induced osteoporosis with pathological fracture
42040	GP clinical event records	N331600	Idiopathic osteoporosis with pathological fracture
42040	GP clinical event records	N331800	Osteoporosis + pathological fracture lumbar vertebrae
42040	GP clinical event records	N331900	Osteoporosis + pathological fracture thoracic vertebrae
42040	GP clinical event records	N331A00	Osteoporosis + pathological fracture cervical vertebrae
42040	GP clinical event records	N331B00	Postmenopausal osteoporosis with pathological fracture
42040	GP clinical event records	N331H00	Collapse of cervical vertebra due to osteoporosis
42040	GP clinical event records	N331J00	Collapse of lumbar vertebra due to osteoporosis
42040	GP clinical event records	N331K00	Collapse of thoracic vertebra due to osteoporosis
42040	GP clinical event records	N331L00	Collapse of vertebra due to osteoporosis NOS
42040	GP clinical event records	N331M00	Fragility fracture due to unspecified osteoporosis
42040	GP clinical event records	N331M11	Minimal trauma fracture due to unspecified osteoporosis
42040	GP clinical event records	N331N00	Fragility fracture
42040	GP clinical event records	N331N11	Minimal trauma fracture
42040	GP clinical event records	N374600	Osteoporotic kyphosis
42040	GP clinical event records	NyuB000	[X]Other osteoporosis with pathological fracture
42040	GP clinical event records	NyuB100	[X]Other osteoporosis
42040	GP clinical event records	NyuB200	[X]Osteoporosis in other disorders classified elsewhere
42040	GP clinical event records	NyuB800	[X]Unspecified osteoporosis with pathological fracture
42040	GP clinical event records	XaISW	Osteoporosis monitoring verbal invitation
42040	GP clinical event records	XaISY	Osteoporosis monitoring deleted
42040	GP clinical event records	XaD4I	Collapse of lumbar vertebra due to osteoporosis
42040	GP clinical event records	XaISZ	Osteoporosis monitoring check done
42040	GP clinical event records	XaISV	Osteoporosis monitoring third letter
42040	GP clinical event records	XaIIp	Fragility fracture due to unspecified osteoporosis
42040	GP clinical event records	XaISQ	Attends osteoporosis monitoring
42040	GP clinical event records	XaISP	Osteoporosis monitoring administration
42040	GP clinical event records	XaITb	Lumbar DXA scan result osteoporotic
42040	GP clinical event records	XaISd	Osteoporosis monitoring
42040	GP clinical event records	XaD4J	Collapse of thoracic vertebra due to osteoporosis
42040	GP clinical event records	XaIP4	Osteoporosis due to corticosteroids
42040	GP clinical event records	XaD4K	Collapse of vertebra due to osteoporosis NOS
42040	GP clinical event records	XaIST	Osteoporosis monitoring first letter
42040	GP clinical event records	XaISX	Osteoporosis monitoring telephone invitation
42040	GP clinical event records	XaNSP	Fragility fracture
42040	GP clinical event records	XaQgT	History of osteoporosis
42040	GP clinical event records	XaISS	Osteoporosis monitoring default
42040	GP clinical event records	XaITW	Hip DXA scan result osteoporotic
42040	GP clinical event records	XaISU	Osteoporosis monitoring second letter
42040	GP clinical event records	XaPE2	Femoral neck DEXA scan result osteoporotic
42040	GP clinical event records	XaD2s	Collapse of cervical vertebra due to osteoporosis