Other anaemias

Metadata

Name	Other anaemias (oth_anaemia)
Category	Haematological or immunological
Sex
Adult	Yes
UUID	24398bf2-8099-452e-a015-edc7a7cf3fb6

Ontologies

Disease Ontology (DOID)	DOID_2355
MeSH	D000740
FinnGen	D3_OTHERANAEMIA

Key Summary Statistics

Cases from any source

Total	35331
Female (%)	21104 (60%)
Male (%)	14227 (40%)

Year first recorded

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Incidence & prevalence

Baseline prevalence stratified by sex

Female	514.53 (499.67,529.4)
Male	198.23 (188.01,208.45)

Incidence stratified by sex

Female	37.73 (36.08,39.38)
Male	35.92 (34.19,37.65)

Incidence stratified by age

Ages 40-44	26.12 (22.88,29.37)
Ages 45-49	27.43 (24.56,30.29)
Ages 50-54	24.94 (22.41,27.46)
Ages 55-59	29.59 (27.1,32.07)
Ages 60-64	42.65 (40.08,45.22)
Ages 65-69	57.87 (54.44,61.31)

Period prevalence

Methods

Comparison with general population

Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)

Population	Ages 40-49	Ages 50-59	Ages 60-69
UK Biobank	476 (456,497)	537 (520,555)	634 (618,651)
CALIBER	431 (426,437)	489 (482,495)	649 (641,657)

Stratified by age and Townsend deprivation status

Deprivation status	Ages 40-49	Ages 50-59	Ages 60-69
Least deprived	431(386,480)	459(424,496)	526(494,559)
Low	404(360,451)	494(458,533)	564(532,598)
Medium	468(423,518)	520(483,560)	603(569,639)
High	502(458,548)	552(514,592)	684(646,724)
Most deprived	544(500,590)	654(612,698)	840(795,886)

Stratified by age and country

Country	Ages 40-49	Ages 50-59	Ages 60-69
England	458(436,480)	520(501,539)	622(604,640)
Scotland	444(389,503)	523(477,571)	601(556,649)
Wales	741(650,841)	731(661,805)	816(751,887)

Risk factors analysis

‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.

Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method

N=153321, Events=259

Factor	Level	Hazard Ratio	P value
BMI	overweight	1.47 (1.07, 2.01)	0.0165
BMI	obese	2.46 (1.81, 3.35)	1.19e-08
BMI	underweight	0 (0, Inf)	0.998
smoking	previous	1.06 (0.81, 1.39)	0.676
smoking	current	0.75 (0.46, 1.22)	0.25
hypertension	yes	0.83 (0.58, 1.19)	0.31

Definition

UK Biobank field id	Description	Code	Value
41202	Diagnoses - main ICD10	D53	Other nutritional anaemias
41202	Diagnoses - main ICD10	D62	Acute posthaemorrhagic anaemia
41202	Diagnoses - main ICD10	D63	Anaemia in chronic diseases classified elsewhere
41202	Diagnoses - main ICD10	D64	Other anaemias
41204	Diagnoses - secondary ICD10	D53	Other nutritional anaemias
41204	Diagnoses - secondary ICD10	D62	Acute posthaemorrhagic anaemia
41204	Diagnoses - secondary ICD10	D63	Anaemia in chronic diseases classified elsewhere
41204	Diagnoses - secondary ICD10	D64	Other anaemias
40001	Underlying (primary) cause of death: ICD10	D53	Other nutritional anaemias
40001	Underlying (primary) cause of death: ICD10	D62	Acute posthaemorrhagic anaemia
40001	Underlying (primary) cause of death: ICD10	D63	Anaemia in chronic diseases classified elsewhere
40001	Underlying (primary) cause of death: ICD10	D64	Other anaemias
40002	Contributory (secondary) causes of death: ICD10	D53	Other nutritional anaemias
40002	Contributory (secondary) causes of death: ICD10	D62	Acute posthaemorrhagic anaemia
40002	Contributory (secondary) causes of death: ICD10	D63	Anaemia in chronic diseases classified elsewhere
40002	Contributory (secondary) causes of death: ICD10	D64	Other anaemias
42040	GP clinical event records	145..11	H/O: anaemia
42040	GP clinical event records	1454.00	H/O: anaemia NOS
42040	GP clinical event records	4234.00	Haemoglobin very low
42040	GP clinical event records	4235.00	Haemoglobin low
42040	GP clinical event records	D00..11	Hypochromic - microcytic anaemia
42040	GP clinical event records	D00..12	Microcytic - hypochromic anaemia
42040	GP clinical event records	D00y100	Microcytic hypochromic anaemia
42040	GP clinical event records	D00z200	Idiopathic hypochromic anaemia
42040	GP clinical event records	D012112	Megaloblastic anaemia due to dietary causes
42040	GP clinical event records	D012500	Macrocytic anaemia unspecified cause
42040	GP clinical event records	D013.00	Other specified megaloblastic anaemia NEC
42040	GP clinical event records	D013z00	Other specified megaloblastic anaemia NEC NOS
42040	GP clinical event records	D014000	Amino-acid deficiency anaemia
42040	GP clinical event records	D014100	Oroticaciduria
42040	GP clinical event records	D014.00	Protein-deficiency anaemia
42040	GP clinical event records	D014z00	Protein-deficiency anaemia NOS
42040	GP clinical event records	D01..00	Other deficiency anaemias
42040	GP clinical event records	D01..11	Megaloblastic anaemia
42040	GP clinical event records	D01y000	Vitamin C deficiency anaemia
42040	GP clinical event records	D01y100	Vitamin E deficiency anaemia
42040	GP clinical event records	D01y.00	Other specified nutritional deficiency anaemia
42040	GP clinical event records	D01yy00	Other specified other nutritional deficiency anaemia
42040	GP clinical event records	D01yz00	Other specified nutritional deficiency anaemia NOS
42040	GP clinical event records	D01z000	[X]Megaloblastic anaemia NOS
42040	GP clinical event records	D01z.00	Other deficiency anaemias NOS
42040	GP clinical event records	D01z.11	Megaloblastic anaemia NOS
42040	GP clinical event records	D0…00	Deficiency anaemias
42040	GP clinical event records	D0y..00	Other specified deficiency anaemias
42040	GP clinical event records	D0z..00	Deficiency anaemias NOS
42040	GP clinical event records	D210000	Congenital sideroblastic anaemia
42040	GP clinical event records	D210100	Acquired sideroblastic anaemia
42040	GP clinical event records	D210200	Pyridoxine-responsive sideroblastic anaemia
42040	GP clinical event records	D210300	Secondary sideroblastic anaemia due to disease
42040	GP clinical event records	D210400	Secondary sideroblastic anaemia due to drugs and toxins
42040	GP clinical event records	D210.00	Sideroblastic anaemia
42040	GP clinical event records	D210z00	Sideroblastic anaemia NOS
42040	GP clinical event records	D211.00	Acute posthaemorrhagic anaemia
42040	GP clinical event records	D211.11	Normocytic anaemia following acute bleed
42040	GP clinical event records	D212000	Anaemia in ovarian carcinoma
42040	GP clinical event records	D212.00	Anaemia in neoplastic disease
42040	GP clinical event records	D213.00	Refractory Anaemia
42040	GP clinical event records	D214.00	Chronic anaemia
42040	GP clinical event records	D215000	Anaemia secondary to chronic renal failure
42040	GP clinical event records	D215.00	Anaemia secondary to renal failure
42040	GP clinical event records	D21..00	Other and unspecified anaemias
42040	GP clinical event records	D21y000	Congenital dyshaematopoietic anaemia
42040	GP clinical event records	D21y011	Congenital dyserythropoietic anaemia
42040	GP clinical event records	D21y012	Congenital dyserythropoiesis NEC
42040	GP clinical event records	D21y200	Leukoerythroblastic anaemia
42040	GP clinical event records	D21y300	Hereditary erythroblast multinuclearity + positive acid test
42040	GP clinical event records	D21y.00	Other specified anaemias
42040	GP clinical event records	D21yy00	Other specified other anaemia
42040	GP clinical event records	D21yz00	Other specified anaemia NOS
42040	GP clinical event records	D21z.00	Anaemia unspecified
42040	GP clinical event records	D21z.11	Secondary anaemia NOS
42040	GP clinical event records	D21z.12	Normocytic anaemia due to unspecified cause
42040	GP clinical event records	D21z.13	Macrocytic anaemia of unspecified cause
42040	GP clinical event records	D2…00	Aplastic and other anaemias
42040	GP clinical event records	D2y..00	Other specified anaemias
42040	GP clinical event records	D2z..00	Other anaemias NOS
42040	GP clinical event records	Dyu0.00	[X]Nutritional anaemias
42040	GP clinical event records	Dyu2200	[X]Anaemia in other chronic diseases classified elsewhere
42040	GP clinical event records	Dyu2400	[X]Other specified anaemias
42040	GP clinical event records	Q455000	Congenital anaemia from fetal blood loss
42040	GP clinical event records	Q455.00	Congenital anaemia
42040	GP clinical event records	Q456.00	Anaemia of prematurity
42040	GP clinical event records	Qyu5C00	[X]Other congenital anaemias, not elsewhere classified
42040	GP clinical event records	XaCLy	Anaemia secondary to chronic renal failure
42040	GP clinical event records	XE13j	Other deficiency anaemias NOS
42040	GP clinical event records	XE13f	Other deficiency anaemias
42040	GP clinical event records	XE13x	Acute posthaemorrhagic anaemia
42040	GP clinical event records	XaCLx	Anaemia secondary to renal failure
42040	GP clinical event records	XaBDS	Anaemia in ovarian carcinoma
42040	GP clinical event records	XE140	Anaemia unspecified
42040	GP clinical event records	XE0q5	H/O: blood disorder
42040	GP clinical event records	D2y..	Other specified anaemias
42040	GP clinical event records	XE13b	Deficiency anaemias