Other haemolytic anaemias

Metadata

Name	Other haemolytic anaemias (oth_haem_anaemia)
Category	Haematological or immunological
Sex
Adult	Yes
UUID	01450425-9cac-4f65-bfe8-51c35a1f1566
Definition	An autoimmune disease of blood that is characterized by deficient red blood cells caused by auto-antibodies.

Ontologies

Disease Ontology (DOID)	DOID_718
MeSH	D000745
SNOMED-CT	61261009
FinnGen	D3_HEREDHAEMOLYTICANAEMIAOTHERNAS

Key Summary Statistics

Cases from any source

Total	641
Female (%)	338 (53%)
Male (%)	303 (47%)

Year first recorded

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Incidence & prevalence

Baseline prevalence stratified by sex

Female	7.66 (5.8,9.52)
Male	8.12 (6.03,10.21)

Incidence stratified by sex

Female	0.62 (0.41,0.82)
Male	0.65 (0.42,0.88)

Incidence stratified by age

Ages 40-44	0.1 (-0.1,0.3)
Ages 45-49	0.59 (0.18,1.0)
Ages 50-54	0.38 (0.08,0.68)
Ages 55-59	0.57 (0.23,0.91)
Ages 60-64	0.65 (0.34,0.96)
Ages 65-69	1.16 (0.68,1.63)

Period prevalence

Methods

Comparison with general population

Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)

Population	Ages 40-49	Ages 50-59	Ages 60-69
UK Biobank	10 (7,14)	11 (9,14)	13 (11,15)
CALIBER	10 (9,11)	9 (8,10)	12 (11,13)

Stratified by age and Townsend deprivation status

Deprivation status	Ages 40-49	Ages 50-59	Ages 60-69
Least deprived	13(6,25)	11(6,19)	13(8,19)
Low	11(5,22)	10(5,17)	12(8,18)
Medium	6(2,15)	11(6,19)	9(5,15)
High	8(3,16)	9(5,16)	14(9,21)
Most deprived	12(7,21)	14(8,22)	17(11,25)

Stratified by age and country

Country	Ages 40-49	Ages 50-59	Ages 60-69
England	11(7,15)	12(9,15)	14(11,17)
Scotland	8(2,21)	10(5,20)	7(3,14)
Wales	10(2,31)	4(0,14)	13(6,25)

Definition

UK Biobank field id	Description	Code	Value
41202	Diagnoses - main ICD10	D55	Anaemia due to enzyme disorders
41202	Diagnoses - main ICD10	D58	Other hereditary haemolytic anaemias
41202	Diagnoses - main ICD10	D59	Acquired haemolytic anaemia
41204	Diagnoses - secondary ICD10	D55	Anaemia due to enzyme disorders
41204	Diagnoses - secondary ICD10	D58	Other hereditary haemolytic anaemias
41204	Diagnoses - secondary ICD10	D59	Acquired haemolytic anaemia
40001	Underlying (primary) cause of death: ICD10	D55	Anaemia due to enzyme disorders
40001	Underlying (primary) cause of death: ICD10	D58	Other hereditary haemolytic anaemias
40001	Underlying (primary) cause of death: ICD10	D59	Acquired haemolytic anaemia
40002	Contributory (secondary) causes of death: ICD10	D55	Anaemia due to enzyme disorders
40002	Contributory (secondary) causes of death: ICD10	D58	Other hereditary haemolytic anaemias
40002	Contributory (secondary) causes of death: ICD10	D59	Acquired haemolytic anaemia
42040	GP clinical event records	1453.00	H/O: haemolytic anaemia
42040	GP clinical event records	D100.00	Hereditary spherocytosis
42040	GP clinical event records	D100.11	Acholuric familial jaundice
42040	GP clinical event records	D100.12	Minkowski - Chauffard syndrome
42040	GP clinical event records	D101.00	Hereditary elliptocytosis
42040	GP clinical event records	D101.11	Ovalocytosis - hereditary
42040	GP clinical event records	D102000	Glucose-6-phosphate dehydrogenase deficiency anaemia
42040	GP clinical event records	D102100	Favism
42040	GP clinical event records	D102200	Drug-induced enzyme deficiency anaemia
42040	GP clinical event records	D102.00	Haemolytic anaemia due to glutathione metabolism disorder
42040	GP clinical event records	D103000	Haemolytic anaemia due to hexokinase deficiency
42040	GP clinical event records	D103100	Haemolytic anaemia due to pyruvate kinase deficiency
42040	GP clinical event records	D103300	Anaemia due to disorders of nucleotide metabolism
42040	GP clinical event records	D103z00	Enzyme deficiency haemolytic anaemia NOS
42040	GP clinical event records	D107000	Congenital Heinz-body anaemia
42040	GP clinical event records	D107100	Hereditary persistence of fetal haemoglobin [HPFH]
42040	GP clinical event records	D107111	Hb F disease
42040	GP clinical event records	D107200	Haemoglobin Bart’s disease
42040	GP clinical event records	D107300	Haemoglobin-C disease
42040	GP clinical event records	D107400	Haemoglobin-D disease
42040	GP clinical event records	D107500	Haemoglobin-E disease
42040	GP clinical event records	D107600	Haemoglobin Zurich disease
42040	GP clinical event records	D107700	Haemoglobin-H disease
42040	GP clinical event records	D107.00	Other haemoglobinopathies
42040	GP clinical event records	D107y00	Other specified other haemoglobinopathy
42040	GP clinical event records	D107z00	Other haemoglobinopathy NOS
42040	GP clinical event records	D10..00	Hereditary haemolytic anaemias
42040	GP clinical event records	D10y000	Stomatocytosis
42040	GP clinical event records	D10y.00	Other specified hereditary haemolytic anaemias
42040	GP clinical event records	D10yz00	Other specified hereditary haemolytic anaemia NOS
42040	GP clinical event records	D10z.00	Hereditary haemolytic anaemia NOS
42040	GP clinical event records	D110000	Primary cold-type haemolytic anaemia
42040	GP clinical event records	D110100	Primary warm-type haemolytic anaemia
42040	GP clinical event records	D110200	Secondary cold-type haemolytic anaemia
42040	GP clinical event records	D110400	Drug-induced autoimmune haemolytic anaemia
42040	GP clinical event records	D110.00	Autoimmune haemolytic anaemias
42040	GP clinical event records	D110.11	Coombs positive haemolysis
42040	GP clinical event records	D110z00	Autoimmune haemolytic anaemia NOS
42040	GP clinical event records	D111000	Mechanical haemolytic anaemia
42040	GP clinical event records	D111100	Microangiopathic haemolytic anaemia
42040	GP clinical event records	D111300	Haemolytic-uraemic syndrome
42040	GP clinical event records	D111400	Drug-induced haemolytic anaemia
42040	GP clinical event records	D111500	Infective haemolytic anaemia
42040	GP clinical event records	D111.00	Non-autoimmune haemolytic anaemia
42040	GP clinical event records	D111y00	Other specified non-autoimmune haemolytic anaemia
42040	GP clinical event records	D111z00	Non-autoimmune haemolytic anaemia NOS
42040	GP clinical event records	D112000	Haemoglobinuria from exertion
42040	GP clinical event records	D112011	March haemoglobinuria
42040	GP clinical event records	D112012	Marchiafava - Micheli syndrome
42040	GP clinical event records	D112100	Paroxysmal nocturnal haemoglobinuria
42040	GP clinical event records	D112200	Paroxysmal cold haemoglobinuria
42040	GP clinical event records	D112.00	Haemoglobinuria due to haemolysis from external causes
42040	GP clinical event records	D112z00	Haemoglobinuria due to haemolysis from external cause NOS
42040	GP clinical event records	D112z11	Cold haemoglobinuria
42040	GP clinical event records	D112z12	Acquired haemolytic anaemia with haemoglobinuria NEC
42040	GP clinical event records	D112z13	Paroxysmal haemoglobinuria NOS
42040	GP clinical event records	D11..00	Acquired haemolytic anaemias
42040	GP clinical event records	D11z000	Acquired spherocytosis
42040	GP clinical event records	D11z100	Pyknocytosis, infantile
42040	GP clinical event records	D11z.00	Acquired haemolytic anaemia NOS
42040	GP clinical event records	D1…00	Haemolytic anaemias
42040	GP clinical event records	D1y..00	Other specified haemolytic anaemias
42040	GP clinical event records	D1z..00	Haemolytic anaemias NOS
42040	GP clinical event records	Dyu1300	[X]Other haemoglobinopathies
42040	GP clinical event records	Dyu1500	[X]Other autoimmune haemolytic anaemias
42040	GP clinical event records	Dyu1.00	[X]Haemolytic anaemias
42040	GP clinical event records	Q430000	Neonatal jaundice + glucose-6-phosphate dehydrogenase defic.
42040	GP clinical event records	Q430.00	Perinatal jaundice from hereditary haemolytic anaemias
42040	GP clinical event records	Q430z00	Perinatal jaundice from hereditary haemolytic anaemia NOS
42040	GP clinical event records	XaC0z	Drug-induced autoimmune haemolytic anaemia
42040	GP clinical event records	XE13p	Haemoglobinuria due to haemolysis from external cause NOS