Metadata
| Name | Other nervous system infections (oth_nerv_sys) |
| Category | Infections |
| Sex | |
| Adult | Yes |
| UUID | 37d58e59-0d1e-488c-9157-7cd25f413bd8 |
| Definition | Other nervous system infections |
Cases from any source
| Total | 1522 |
| Female (%) | 768 (50%) |
| Male (%) | 754 (50%) |
Year first recorded
Cases linked in all UK Biobank sources
Cross-source concordance
Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.
Incidence & prevalence
Baseline prevalence stratified by sex
| Female | 8.61 (6.63,10.58) |
| Male | 10.08 (7.75,12.41) |
Incidence stratified by sex
| Female | 1.18 (0.9,1.46) |
| Male | 1.31 (0.98,1.63) |
Incidence stratified by age
| Ages 40-44 | 0.1 (-0.1,0.3) |
| Ages 45-49 | 1.11 (0.55,1.68) |
| Ages 50-54 | 1.27 (0.71,1.82) |
| Ages 55-59 | 1.09 (0.62,1.56) |
| Ages 60-64 | 1.69 (1.19,2.19) |
| Ages 65-69 | 1.41 (0.89,1.93) |
Period prevalence
Methods
Comparison with general population
Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)
| Population | Ages 40-49 | Ages 50-59 | Ages 60-69 |
| UK Biobank | 8 (6,11) | 14 (11,17) | 17 (14,20) |
| CALIBER | 8 (7,9) | 11 (10,12) | 18 (17,20) |
Stratified by age and Townsend deprivation status
| Deprivation status | Ages 40-49 | Ages 50-59 | Ages 60-69 |
| Least deprived | 5(1,14) | 12(7,20) | 17(11,24) |
| Low | 4(1,11) | 12(7,20) | 15(10,21) |
| Medium | 13(6,23) | 15(9,24) | 14(9,20) |
| High | 8(3,16) | 12(7,20) | 14(9,21) |
| Most deprived | 10(5,18) | 19(12,28) | 24(17,33) |
Stratified by age and country
| Country | Ages 40-49 | Ages 50-59 | Ages 60-69 |
| England | 9(6,13) | 13(10,17) | 16(13,19) |
| Scotland | 3(0,12) | 21(12,33) | 21(13,32) |
| Wales | 7(1,24) | 10(3,23) | 19(10,32) |
Risk factors analysis
‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.
Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method
N=153969, Events=129
| Factor | Level | Hazard Ratio | P value |
| BMI | overweight | 1.18 (0.74, 1.86) | 0.489 |
| BMI | obese | 1.91 (1.2, 3.06) | 0.00685 |
| BMI | underweight | 0 (0, Inf) | 0.995 |
| smoking | previous | 1.29 (0.88, 1.87) | 0.189 |
| smoking | current | 1.41 (0.81, 2.45) | 0.23 |
| hypertension | yes | 1.93 (1.34, 2.77) | 0.000403 |
Definition
| UK Biobank field id | Description | Code | Value |
|---|---|---|---|
| 20002 | Non-cancer illness code, self-reported | 1245 | brain abscess/intracranial abscess |
| 20002 | Non-cancer illness code, self-reported | 1248 | spinal abscess |
| 41202 | Diagnoses - main ICD10 | A06.6 | Amoebic brain abscess |
| 41202 | Diagnoses - main ICD10 | A17.8 | Other tuberculosis of nervous system |
| 41202 | Diagnoses - main ICD10 | A17.9 | Tuberculosis of nervous system, unspecified |
| 41202 | Diagnoses - main ICD10 | A52.1 | Symptomatic neurosyphilis |
| 41202 | Diagnoses - main ICD10 | A52.2 | Asymptomatic neurosyphilis |
| 41202 | Diagnoses - main ICD10 | A52.3 | Neurosyphilis, unspecified |
| 41202 | Diagnoses - main ICD10 | A80 | Acute poliomyelitis |
| 41202 | Diagnoses - main ICD10 | A81 | Atypical virus infections of central nervous system |
| 41202 | Diagnoses - main ICD10 | A82 | Rabies |
| 41202 | Diagnoses - main ICD10 | A88 | Other viral infections of central nervous system, not elsewhere classified |
| 41202 | Diagnoses - main ICD10 | A89 | Unspecified viral infection of central nervous system |
| 41202 | Diagnoses - main ICD10 | B02.2 | Zoster with other nervous system involvement |
| 41202 | Diagnoses - main ICD10 | B06.0 | Rubella with neurological complications |
| 41202 | Diagnoses - main ICD10 | B43.1 | Phaeomycotic brain abscess |
| 41202 | Diagnoses - main ICD10 | B45.1 | Cerebral cryptococcosis |
| 41202 | Diagnoses - main ICD10 | B50.0 | Plasmodium falciparum malaria with cerebral complications |
| 41202 | Diagnoses - main ICD10 | B58.2 | Toxoplasma meningoencephalitis |
| 41202 | Diagnoses - main ICD10 | B69.0 | Cysticercosis of central nervous system |
| 41202 | Diagnoses - main ICD10 | B90.0 | Sequelae of central nervous system tuberculosis |
| 41202 | Diagnoses - main ICD10 | B91 | Sequelae of poliomyelitis |
| 41202 | Diagnoses - main ICD10 | G04.2 | Bacterial meningoencephalitis and meningomyelitis, not elsewhere classified |
| 41202 | Diagnoses - main ICD10 | G04.8 | Other encephalitis, myelitis and encephalomyelitis |
| 41202 | Diagnoses - main ICD10 | G04.9 | Encephalitis, myelitis and encephalomyelitis, unspecified |
| 41202 | Diagnoses - main ICD10 | G05.0 | Encephalitis, myelitis and encephalomyelitis in bacterial diseases classified elsewhere |
| 41202 | Diagnoses - main ICD10 | G05.1 | Encephalitis, myelitis and encephalomyelitis in viral diseases classified elsewhere |
| 41202 | Diagnoses - main ICD10 | G05.2 | Encephalitis, myelitis and encephalomyelitis in other infectious and parasitic diseases classified elsewhere |
| 41202 | Diagnoses - main ICD10 | G06 | Intracranial and intraspinal abscess and granuloma |
| 41202 | Diagnoses - main ICD10 | G07 | Intracranial and intraspinal abscess and granuloma in diseases classified elsewhere |
| 41202 | Diagnoses - main ICD10 | G08 | Intracranial and intraspinal phlebitis and thrombophlebitis |
| 41202 | Diagnoses - main ICD10 | M89.6 | Osteopathy after poliomyelitis |
| 41204 | Diagnoses - secondary ICD10 | A06.6 | Amoebic brain abscess |
| 41204 | Diagnoses - secondary ICD10 | A17.8 | Other tuberculosis of nervous system |
| 41204 | Diagnoses - secondary ICD10 | A17.9 | Tuberculosis of nervous system, unspecified |
| 41204 | Diagnoses - secondary ICD10 | A52.1 | Symptomatic neurosyphilis |
| 41204 | Diagnoses - secondary ICD10 | A52.2 | Asymptomatic neurosyphilis |
| 41204 | Diagnoses - secondary ICD10 | A52.3 | Neurosyphilis, unspecified |
| 41204 | Diagnoses - secondary ICD10 | A80 | Acute poliomyelitis |
| 41204 | Diagnoses - secondary ICD10 | A81 | Atypical virus infections of central nervous system |
| 41204 | Diagnoses - secondary ICD10 | A82 | Rabies |
| 41204 | Diagnoses - secondary ICD10 | A88 | Other viral infections of central nervous system, not elsewhere classified |
| 41204 | Diagnoses - secondary ICD10 | A89 | Unspecified viral infection of central nervous system |
| 41204 | Diagnoses - secondary ICD10 | B02.2 | Zoster with other nervous system involvement |
| 41204 | Diagnoses - secondary ICD10 | B06.0 | Rubella with neurological complications |
| 41204 | Diagnoses - secondary ICD10 | B43.1 | Phaeomycotic brain abscess |
| 41204 | Diagnoses - secondary ICD10 | B45.1 | Cerebral cryptococcosis |
| 41204 | Diagnoses - secondary ICD10 | B50.0 | Plasmodium falciparum malaria with cerebral complications |
| 41204 | Diagnoses - secondary ICD10 | B58.2 | Toxoplasma meningoencephalitis |
| 41204 | Diagnoses - secondary ICD10 | B69.0 | Cysticercosis of central nervous system |
| 41204 | Diagnoses - secondary ICD10 | B90.0 | Sequelae of central nervous system tuberculosis |
| 41204 | Diagnoses - secondary ICD10 | B91 | Sequelae of poliomyelitis |
| 41204 | Diagnoses - secondary ICD10 | G04.2 | Bacterial meningoencephalitis and meningomyelitis, not elsewhere classified |
| 41204 | Diagnoses - secondary ICD10 | G04.8 | Other encephalitis, myelitis and encephalomyelitis |
| 41204 | Diagnoses - secondary ICD10 | G04.9 | Encephalitis, myelitis and encephalomyelitis, unspecified |
| 41204 | Diagnoses - secondary ICD10 | G05.0 | Encephalitis, myelitis and encephalomyelitis in bacterial diseases classified elsewhere |
| 41204 | Diagnoses - secondary ICD10 | G05.1 | Encephalitis, myelitis and encephalomyelitis in viral diseases classified elsewhere |
| 41204 | Diagnoses - secondary ICD10 | G05.2 | Encephalitis, myelitis and encephalomyelitis in other infectious and parasitic diseases classified elsewhere |
| 41204 | Diagnoses - secondary ICD10 | G06 | Intracranial and intraspinal abscess and granuloma |
| 41204 | Diagnoses - secondary ICD10 | G07 | Intracranial and intraspinal abscess and granuloma in diseases classified elsewhere |
| 41204 | Diagnoses - secondary ICD10 | G08 | Intracranial and intraspinal phlebitis and thrombophlebitis |
| 41204 | Diagnoses - secondary ICD10 | M89.6 | Osteopathy after poliomyelitis |
| 40001 | Underlying (primary) cause of death: ICD10 | A06.6 | Amoebic brain abscess |
| 40001 | Underlying (primary) cause of death: ICD10 | A17.8 | Other tuberculosis of nervous system |
| 40001 | Underlying (primary) cause of death: ICD10 | A17.9 | Tuberculosis of nervous system, unspecified |
| 40001 | Underlying (primary) cause of death: ICD10 | A52.1 | Symptomatic neurosyphilis |
| 40001 | Underlying (primary) cause of death: ICD10 | A52.2 | Asymptomatic neurosyphilis |
| 40001 | Underlying (primary) cause of death: ICD10 | A52.3 | Neurosyphilis, unspecified |
| 40001 | Underlying (primary) cause of death: ICD10 | A80 | Acute poliomyelitis |
| 40001 | Underlying (primary) cause of death: ICD10 | A81 | Atypical virus infections of central nervous system |
| 40001 | Underlying (primary) cause of death: ICD10 | A82 | Rabies |
| 40001 | Underlying (primary) cause of death: ICD10 | A88 | Other viral infections of central nervous system, not elsewhere classified |
| 40001 | Underlying (primary) cause of death: ICD10 | A89 | Unspecified viral infection of central nervous system |
| 40001 | Underlying (primary) cause of death: ICD10 | B02.2 | Zoster with other nervous system involvement |
| 40001 | Underlying (primary) cause of death: ICD10 | B06.0 | Rubella with neurological complications |
| 40001 | Underlying (primary) cause of death: ICD10 | B43.1 | Phaeomycotic brain abscess |
| 40001 | Underlying (primary) cause of death: ICD10 | B45.1 | Cerebral cryptococcosis |
| 40001 | Underlying (primary) cause of death: ICD10 | B50.0 | Plasmodium falciparum malaria with cerebral complications |
| 40001 | Underlying (primary) cause of death: ICD10 | B58.2 | Toxoplasma meningoencephalitis |
| 40001 | Underlying (primary) cause of death: ICD10 | B69.0 | Cysticercosis of central nervous system |
| 40001 | Underlying (primary) cause of death: ICD10 | B90.0 | Sequelae of central nervous system tuberculosis |
| 40001 | Underlying (primary) cause of death: ICD10 | B91 | Sequelae of poliomyelitis |
| 40001 | Underlying (primary) cause of death: ICD10 | G04.2 | Bacterial meningoencephalitis and meningomyelitis, not elsewhere classified |
| 40001 | Underlying (primary) cause of death: ICD10 | G04.8 | Other encephalitis, myelitis and encephalomyelitis |
| 40001 | Underlying (primary) cause of death: ICD10 | G04.9 | Encephalitis, myelitis and encephalomyelitis, unspecified |
| 40001 | Underlying (primary) cause of death: ICD10 | G05.0 | Encephalitis, myelitis and encephalomyelitis in bacterial diseases classified elsewhere |
| 40001 | Underlying (primary) cause of death: ICD10 | G05.1 | Encephalitis, myelitis and encephalomyelitis in viral diseases classified elsewhere |
| 40001 | Underlying (primary) cause of death: ICD10 | G05.2 | Encephalitis, myelitis and encephalomyelitis in other infectious and parasitic diseases classified elsewhere |
| 40001 | Underlying (primary) cause of death: ICD10 | G06 | Intracranial and intraspinal abscess and granuloma |
| 40001 | Underlying (primary) cause of death: ICD10 | G07 | Intracranial and intraspinal abscess and granuloma in diseases classified elsewhere |
| 40001 | Underlying (primary) cause of death: ICD10 | G08 | Intracranial and intraspinal phlebitis and thrombophlebitis |
| 40001 | Underlying (primary) cause of death: ICD10 | M89.6 | Osteopathy after poliomyelitis |
| 40002 | Contributory (secondary) causes of death: ICD10 | A06.6 | Amoebic brain abscess |
| 40002 | Contributory (secondary) causes of death: ICD10 | A17.8 | Other tuberculosis of nervous system |
| 40002 | Contributory (secondary) causes of death: ICD10 | A17.9 | Tuberculosis of nervous system, unspecified |
| 40002 | Contributory (secondary) causes of death: ICD10 | A52.1 | Symptomatic neurosyphilis |
| 40002 | Contributory (secondary) causes of death: ICD10 | A52.2 | Asymptomatic neurosyphilis |
| 40002 | Contributory (secondary) causes of death: ICD10 | A52.3 | Neurosyphilis, unspecified |
| 40002 | Contributory (secondary) causes of death: ICD10 | A80 | Acute poliomyelitis |
| 40002 | Contributory (secondary) causes of death: ICD10 | A81 | Atypical virus infections of central nervous system |
| 40002 | Contributory (secondary) causes of death: ICD10 | A82 | Rabies |
| 40002 | Contributory (secondary) causes of death: ICD10 | A88 | Other viral infections of central nervous system, not elsewhere classified |
| 40002 | Contributory (secondary) causes of death: ICD10 | A89 | Unspecified viral infection of central nervous system |
| 40002 | Contributory (secondary) causes of death: ICD10 | B02.2 | Zoster with other nervous system involvement |
| 40002 | Contributory (secondary) causes of death: ICD10 | B06.0 | Rubella with neurological complications |
| 40002 | Contributory (secondary) causes of death: ICD10 | B43.1 | Phaeomycotic brain abscess |
| 40002 | Contributory (secondary) causes of death: ICD10 | B45.1 | Cerebral cryptococcosis |
| 40002 | Contributory (secondary) causes of death: ICD10 | B50.0 | Plasmodium falciparum malaria with cerebral complications |
| 40002 | Contributory (secondary) causes of death: ICD10 | B58.2 | Toxoplasma meningoencephalitis |
| 40002 | Contributory (secondary) causes of death: ICD10 | B69.0 | Cysticercosis of central nervous system |
| 40002 | Contributory (secondary) causes of death: ICD10 | B90.0 | Sequelae of central nervous system tuberculosis |
| 40002 | Contributory (secondary) causes of death: ICD10 | B91 | Sequelae of poliomyelitis |
| 40002 | Contributory (secondary) causes of death: ICD10 | G04.2 | Bacterial meningoencephalitis and meningomyelitis, not elsewhere classified |
| 40002 | Contributory (secondary) causes of death: ICD10 | G04.8 | Other encephalitis, myelitis and encephalomyelitis |
| 40002 | Contributory (secondary) causes of death: ICD10 | G04.9 | Encephalitis, myelitis and encephalomyelitis, unspecified |
| 40002 | Contributory (secondary) causes of death: ICD10 | G05.0 | Encephalitis, myelitis and encephalomyelitis in bacterial diseases classified elsewhere |
| 40002 | Contributory (secondary) causes of death: ICD10 | G05.1 | Encephalitis, myelitis and encephalomyelitis in viral diseases classified elsewhere |
| 40002 | Contributory (secondary) causes of death: ICD10 | G05.2 | Encephalitis, myelitis and encephalomyelitis in other infectious and parasitic diseases classified elsewhere |
| 40002 | Contributory (secondary) causes of death: ICD10 | G06 | Intracranial and intraspinal abscess and granuloma |
| 40002 | Contributory (secondary) causes of death: ICD10 | G07 | Intracranial and intraspinal abscess and granuloma in diseases classified elsewhere |
| 40002 | Contributory (secondary) causes of death: ICD10 | G08 | Intracranial and intraspinal phlebitis and thrombophlebitis |
| 40002 | Contributory (secondary) causes of death: ICD10 | M89.6 | Osteopathy after poliomyelitis |