Pancreatitis

Metadata

Name	Pancreatitis (pancreatitis)
Category	Digestive
Sex
Adult	Yes
UUID	fd3132e5-448e-41c3-ac9e-444f3bed28e9
Definition	An acute inflammatory process that leads to necrosis of the pancreatic parenchyma.

Ontologies

Disease Ontology (DOID)	DOID_4989
GWAS Catalogue	EFO_0000278
MeSH	D010195
SNOMED-CT	75694006
FinnGen	K11_ACUTPANC

Key Summary Statistics

Cases from any source

Total	5099
Female (%)	2552 (50%)
Male (%)	2547 (50%)

Year first recorded

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Incidence & prevalence

Baseline prevalence stratified by sex

Female	45.38 (40.86,49.91)
Male	49.42 (44.28,54.56)

Incidence stratified by sex

Female	3.81 (3.31,4.32)
Male	5.16 (4.52,5.81)

Incidence stratified by age

Ages 40-44	2.42 (1.45,3.39)
Ages 45-49	2.9 (1.99,3.81)
Ages 50-54	3.82 (2.85,4.78)
Ages 55-59	4.86 (3.87,5.85)
Ages 60-64	4.1 (3.32,4.88)
Ages 65-69	6.98 (5.82,8.15)

Period prevalence

Methods

Comparison with general population

Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)

Population	Ages 40-49	Ages 50-59	Ages 60-69
UK Biobank	44 (38,51)	63 (57,70)	91 (84,97)
CALIBER	59 (57,61)	77 (74,79)	103 (100,106)

Stratified by age and Townsend deprivation status

Deprivation status	Ages 40-49	Ages 50-59	Ages 60-69
Least deprived	35(22,51)	45(34,59)	77(65,90)
Low	26(15,41)	51(39,65)	72(61,85)
Medium	39(26,57)	44(33,57)	87(74,102)
High	59(44,78)	64(51,79)	92(78,107)
Most deprived	55(41,71)	111(93,130)	131(113,150)

Stratified by age and country

Country	Ages 40-49	Ages 50-59	Ages 60-69
England	44(37,52)	61(54,68)	88(82,95)
Scotland	45(28,68)	66(50,86)	102(84,123)
Wales	48(26,80)	80(58,109)	97(75,123)

Risk factors analysis

‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.

Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method

N=153646, Events=402

Factor	Level	Hazard Ratio	P value
BMI	overweight	1.07 (0.82, 1.39)	0.637
BMI	obese	2.13 (1.65, 2.77)	1.06e-08
BMI	underweight	0 (0, Inf)	0.986
smoking	previous	1.48 (1.19, 1.85)	0.000498
smoking	current	2.47 (1.87, 3.26)	1.43e-10
hypertension	yes	2.21 (1.8, 2.72)	5.76e-14

Definition

UK Biobank field id	Description	Code	Value
20002	Non-cancer illness code, self-reported	1165	pancreatitis
41202	Diagnoses - main ICD10	K85	Acute pancreatitis
41202	Diagnoses - main ICD10	K86.0	Alcohol-induced chronic pancreatitis
41202	Diagnoses - main ICD10	K86.1	Other chronic pancreatitis
41202	Diagnoses - main ICD10	K86.3	Pseudocyst of pancreas
41204	Diagnoses - secondary ICD10	K85	Acute pancreatitis
41204	Diagnoses - secondary ICD10	K86.0	Alcohol-induced chronic pancreatitis
41204	Diagnoses - secondary ICD10	K86.1	Other chronic pancreatitis
41204	Diagnoses - secondary ICD10	K86.3	Pseudocyst of pancreas
40001	Underlying (primary) cause of death: ICD10	K85	Acute pancreatitis
40001	Underlying (primary) cause of death: ICD10	K86.0	Alcohol-induced chronic pancreatitis
40001	Underlying (primary) cause of death: ICD10	K86.1	Other chronic pancreatitis
40001	Underlying (primary) cause of death: ICD10	K86.3	Pseudocyst of pancreas
40002	Contributory (secondary) causes of death: ICD10	K85	Acute pancreatitis
40002	Contributory (secondary) causes of death: ICD10	K86.0	Alcohol-induced chronic pancreatitis
40002	Contributory (secondary) causes of death: ICD10	K86.1	Other chronic pancreatitis
40002	Contributory (secondary) causes of death: ICD10	K86.3	Pseudocyst of pancreas
42040	GP clinical event records	14CG.00	History of acute pancreatitis
42040	GP clinical event records	14CH.00	History of chronic pancreatitis
42040	GP clinical event records	A723.00	Mumps pancreatitis
42040	GP clinical event records	A785100	Cytomegaloviral pancreatitis
42040	GP clinical event records	D201612	Pancytopenia with pancreatitis
42040	GP clinical event records	J670000	Acute pancreatitis unspecified
42040	GP clinical event records	J670100	Acute recurrent pancreatitis
42040	GP clinical event records	J670200	Acute haemorrhagic pancreatitis
42040	GP clinical event records	J670300	Acute suppurative pancreatitis
42040	GP clinical event records	J670400	Subacute pancreatitis
42040	GP clinical event records	J670500	Gallstone acute pancreatitis
42040	GP clinical event records	J670600	Idiopathic acute pancreatitis
42040	GP clinical event records	J670700	Biliary acute pancreatitis
42040	GP clinical event records	J670800	Alcohol-induced acute pancreatitis
42040	GP clinical event records	J670900	Drug-induced acute pancreatitis
42040	GP clinical event records	J670.00	Acute pancreatitis
42040	GP clinical event records	J670y00	Other acute pancreatitis
42040	GP clinical event records	J670z00	Acute pancreatitis NOS
42040	GP clinical event records	J670z11	Pancreatitis
42040	GP clinical event records	J671000	Alcohol-induced chronic pancreatitis
42040	GP clinical event records	J671100	Gallstone chronic pancreatitis
42040	GP clinical event records	J671.00	Chronic pancreatitis
42040	GP clinical event records	J672100	Pseudocyst of pancreas
42040	GP clinical event records	Jyu8400	[X]Other chronic pancreatitis
42040	GP clinical event records	XaYaK	Biliary acute pancreatitis
42040	GP clinical event records	XE13v	Pancytopenia NOS
42040	GP clinical event records	X308k	Idiopathic acute pancreatitis
42040	GP clinical event records	XaLou	History of acute pancreatitis
42040	GP clinical event records	X308j	Alcohol-induced acute pancreatitis
42040	GP clinical event records	X308p	Cytomegaloviral pancreatitis
42040	GP clinical event records	X308l	Drug-induced acute pancreatitis
42040	GP clinical event records	X308v	Alcohol-induced chronic pancreatitis
42040	GP clinical event records	XaLov	History of chronic pancreatitis
42040	GP clinical event records	X308i	Gallstone acute pancreatitis
42040	GP clinical event records	XE0bH	Acute pancreatitis NOS
42040	GP clinical event records	X308u	Gallstone chronic pancreatitis