| Name |
Parkinson’s disease (Parkinsons) |
| Category |
Neurological |
| Sex |
|
| Adult |
Yes |
| UUID |
5d4b14a2-c7aa-411c-a29c-a455f133acbc |
| Definition |
A synucleinopathy that has_material_basis_in degeneration of the central nervous system that often impairs motor skills, speech, and other functions. |
Ontologies
Key Summary Statistics
Cases from any source
| Total |
3812 |
| Female (%) |
1431 (38%) |
| Male (%) |
2381 (62%) |
Year first recorded
Cases linked in all UK Biobank sources
Cross-source concordance
Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.
Incidence & prevalence
Baseline prevalence stratified by sex
| Female |
12.97 (10.54,15.39) |
| Male |
24.78 (21.13,28.42) |
Incidence stratified by sex
| Female |
3.41 (2.93,3.89) |
| Male |
6.06 (5.36,6.76) |
Incidence stratified by age
| Ages 40-44 |
0.4 (0.01,0.8) |
| Ages 45-49 |
1.04 (0.49,1.58) |
| Ages 50-54 |
1.14 (0.61,1.67) |
| Ages 55-59 |
4.48 (3.53,5.43) |
| Ages 60-64 |
5.78 (4.85,6.7) |
| Ages 65-69 |
10.56 (9.13,11.99) |
Period prevalence
Methods
Comparison with general population
Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)
| Population |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| UK Biobank |
5 (3,8) |
23 (19,27) |
73 (68,79) |
| CALIBER |
4 (4,5) |
18 (17,20) |
70 (67,73) |
Stratified by age and Townsend deprivation status
| Deprivation status |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| Least deprived |
5(1,14) |
29(20,40) |
79(67,92) |
| Low |
2(0,9) |
19(12,28) |
70(59,83) |
| Medium |
7(2,16) |
17(10,26) |
73(61,87) |
| High |
7(3,16) |
18(12,27) |
69(57,83) |
| Most deprived |
6(2,13) |
30(21,41) |
75(62,90) |
Stratified by age and country
| Country |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| England |
6(3,9) |
23(19,28) |
73(66,79) |
| Scotland |
6(1,17) |
17(10,28) |
68(53,85) |
| Wales |
4(0,21) |
25(13,44) |
87(67,112) |
Risk factors analysis
‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.
Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method
N=153420, Events=132
| Factor |
Level |
Hazard Ratio |
P value |
| BMI |
overweight |
0.98 (0.66, 1.47) |
0.928 |
| BMI |
obese |
1.08 (0.69, 1.7) |
0.735 |
| BMI |
underweight |
0 (0, Inf) |
0.992 |
| smoking |
previous |
1.16 (0.78, 1.73) |
0.462 |
| smoking |
current |
2.27 (1.45, 3.57) |
0.000355 |
| hypertension |
yes |
1.19 (0.76, 1.85) |
0.449 |
Definition
| UK Biobank field id |
Description |
Code |
Value |
| 20002 |
Non-cancer illness code, self-reported |
1262 |
parkinsons disease |
| 41202 |
Diagnoses - main ICD10 |
F02.3 |
Dementia in Parkinson’s disease |
| 41202 |
Diagnoses - main ICD10 |
G20 |
Parkinson’s disease |
| 41204 |
Diagnoses - secondary ICD10 |
F02.3 |
Dementia in Parkinson’s disease |
| 41204 |
Diagnoses - secondary ICD10 |
G20 |
Parkinson’s disease |
| 40001 |
Underlying (primary) cause of death: ICD10 |
F02.3 |
Dementia in Parkinson’s disease |
| 40001 |
Underlying (primary) cause of death: ICD10 |
G20 |
Parkinson’s disease |
| 40002 |
Contributory (secondary) causes of death: ICD10 |
F02.3 |
Dementia in Parkinson’s disease |
| 40002 |
Contributory (secondary) causes of death: ICD10 |
G20 |
Parkinson’s disease |
| 42040 |
GP clinical event records |
147F.00 |
History of Parkinson’s disease |
| 42040 |
GP clinical event records |
Eu02300 |
[X]Dementia in Parkinson’s disease |
| 42040 |
GP clinical event records |
F11x900 |
Cerebral degeneration in Parkinson’s disease |
| 42040 |
GP clinical event records |
F120.00 |
Paralysis agitans |
| 42040 |
GP clinical event records |
F12..00 |
Parkinson’s disease |
| 42040 |
GP clinical event records |
F12z.00 |
Parkinson’s disease NOS |
| 42040 |
GP clinical event records |
XaQwf |
History of Parkinson’s disease |
| 42040 |
GP clinical event records |
XaOfZ |
Cerebral degeneration in Parkinson’s disease |