| Name |
Postcoital and contact bleeding (PCB) |
| Category |
Genitourinary |
| Sex |
|
| Adult |
Yes |
| UUID |
de3e70ab-9eff-49b2-a2dc-573eb668c274 |
| Definition |
Bleeding from the vagina in women after sexual intercourse and may or may not be associated with pain. |
Ontologies
Key Summary Statistics
Cases from any source
| Total |
3980 |
| Female (%) |
3980 (100%) |
| Male (%) |
0 (0%) |
Year first recorded
Cases linked in all UK Biobank sources
Cross-source concordance
Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.
Incidence & prevalence
Baseline prevalence stratified by sex
| Female |
185.66 (176.57,194.74) |
| Male |
0.0 (0.0,0.0) |
Incidence stratified by sex
| Female |
6.03 (5.38,6.67) |
| Male |
0.0 (0.0,0.0) |
Incidence stratified by age
| Ages 40-44 |
9.5 (7.57,11.43) |
| Ages 45-49 |
7.4 (5.93,8.86) |
| Ages 50-54 |
4.63 (3.56,5.7) |
| Ages 55-59 |
2.58 (1.85,3.3) |
| Ages 60-64 |
0.73 (0.4,1.06) |
| Ages 65-69 |
0.25 (0.03,0.47) |
Period prevalence
Methods
Comparison with general population
Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)
| Population |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| UK Biobank |
200 (187,214) |
150 (142,159) |
73 (67,78) |
| CALIBER |
476 (468,484) |
342 (334,350) |
166 (160,172) |
Stratified by age and Townsend deprivation status
| Deprivation status |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| Least deprived |
215(184,250) |
190(169,213) |
76(64,89) |
| Low |
188(159,221) |
148(129,169) |
86(74,99) |
| Medium |
235(204,270) |
154(135,175) |
71(60,84) |
| High |
191(165,220) |
132(115,152) |
76(64,90) |
| Most deprived |
179(155,206) |
128(111,148) |
50(40,62) |
Stratified by age and country
| Country |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| England |
218(203,234) |
164(154,175) |
77(71,83) |
| Scotland |
57(39,80) |
54(40,70) |
30(21,41) |
| Wales |
251(200,311) |
175(143,212) |
97(76,122) |
Risk factors analysis
‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.
Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method
N=153508, Events=407
| Factor |
Level |
Hazard Ratio |
P value |
| BMI |
overweight |
0.96 (0.75, 1.22) |
0.716 |
| BMI |
obese |
1.36 (1.06, 1.76) |
0.0167 |
| BMI |
underweight |
0 (0, Inf) |
0.986 |
| smoking |
previous |
1.37 (1.1, 1.7) |
0.00438 |
| smoking |
current |
2.14 (1.6, 2.85) |
2.26e-07 |
| hypertension |
yes |
1.88 (1.53, 2.31) |
1.47e-09 |
Definition
| UK Biobank field id |
Description |
Code |
Value |
| 41202 |
Diagnoses - main ICD10 |
N93.0 |
Postcoital and contact bleeding |
| 41204 |
Diagnoses - secondary ICD10 |
N93.0 |
Postcoital and contact bleeding |
| 40001 |
Underlying (primary) cause of death: ICD10 |
N93.0 |
Postcoital and contact bleeding |
| 40002 |
Contributory (secondary) causes of death: ICD10 |
N93.0 |
Postcoital and contact bleeding |
| 42040 |
GP clinical event records |
1581.00 |
H/O: post-coital bleeding |
| 42040 |
GP clinical event records |
K587.00 |
Contact bleeding of cervix |
| 42040 |
GP clinical event records |
K597.00 |
Postcoital bleeding |
| 42040 |
GP clinical event records |
K59A.00 |
Premenopausal postcoital bleeding |
| 42040 |
GP clinical event records |
K59B.00 |
Postmenopausal postcoital bleeding |
| 42040 |
GP clinical event records |
XaKJm |
Postmenopausal postcoital bleeding |
| 42040 |
GP clinical event records |
XaKJl |
Premenopausal postcoital bleeding |