| Name |
Polycythaemia vera (PCV) |
| Category |
Cancers |
| Sex |
|
| Adult |
Yes |
| UUID |
92dce182-7f34-4b44-989e-87c0b8ec402d |
| Definition |
A myeloproliferative neoplasm characterized by erythroid hyperplasia, myeloid leukocytosis, thrombocytosis, and splenomegaly. |
Ontologies
Key Summary Statistics
Cases from any source
| Total |
801 |
| Female (%) |
257 (32%) |
| Male (%) |
544 (68%) |
Year first recorded
Cases linked in all UK Biobank sources
Cross-source concordance
Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.
Incidence & prevalence
Baseline prevalence stratified by sex
| Female |
4.01 (2.66,5.35) |
| Male |
12.6 (10.0,15.2) |
Incidence stratified by sex
| Female |
0.39 (0.22,0.55) |
| Male |
0.86 (0.6,1.13) |
Incidence stratified by age
| Ages 40-44 |
0.1 (-0.1,0.3) |
| Ages 45-49 |
0.07 (-0.07,0.22) |
| Ages 50-54 |
0.7 (0.28,1.11) |
| Ages 55-59 |
0.52 (0.2,0.84) |
| Ages 60-64 |
0.77 (0.43,1.1) |
| Ages 65-69 |
1.01 (0.56,1.45) |
Period prevalence
Methods
Comparison with general population
Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)
| Population |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| UK Biobank |
5 (3,8) |
13 (10,16) |
18 (15,21) |
| CALIBER |
8 (8,9) |
16 (15,17) |
24 (23,26) |
Stratified by age and Townsend deprivation status
| Deprivation status |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| Least deprived |
3(0,10) |
11(6,19) |
12(8,18) |
| Low |
3(0,11) |
11(6,19) |
18(12,25) |
| Medium |
8(3,17) |
11(6,19) |
17(12,24) |
| High |
5(2,12) |
12(7,20) |
23(16,31) |
| Most deprived |
6(2,13) |
18(12,27) |
19(13,28) |
Stratified by age and country
| Country |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| England |
4(2,7) |
11(8,14) |
16(13,19) |
| Scotland |
0(NaN,NaN) |
12(6,22) |
14(7,23) |
| Wales |
24(10,49) |
35(20,56) |
43(28,61) |
Definition
| UK Biobank field id |
Description |
Code |
Value |
| 20002 |
Non-cancer illness code, self-reported |
1438 |
polycythaemia vera |
| 41202 |
Diagnoses - main ICD10 |
D45 |
Polycythaemia vera |
| 41204 |
Diagnoses - secondary ICD10 |
D45 |
Polycythaemia vera |
| 40001 |
Underlying (primary) cause of death: ICD10 |
D45 |
Polycythaemia vera |
| 40002 |
Contributory (secondary) causes of death: ICD10 |
D45 |
Polycythaemia vera |
| 42040 |
GP clinical event records |
B671.00 |
Chronic erythraemia |
| 42040 |
GP clinical event records |
B671.11 |
Heilmeyer - Schoner disease |
| 42040 |
GP clinical event records |
B934.00 |
Polycythaemia vera |
| 42040 |
GP clinical event records |
B934.11 |
Polycythaemia rubra vera |
| 42040 |
GP clinical event records |
B934.12 |
Primary polycythaemia |
| 42040 |
GP clinical event records |
BBs0.00 |
[M]Polycythaemia vera |
| 42040 |
GP clinical event records |
BBs0.11 |
[M]Polycythaemia rubra vera |
| 42040 |
GP clinical event records |
XE1vr |
Chronic erythraemia |