| Name |
Pulmonary embolism (PE) |
| Category |
Cardiovascular |
| Sex |
|
| Adult |
Yes |
| UUID |
cda2cd0f-2038-45fd-b77c-e84b59185605 |
| Definition |
The obstruction of the pulmonary artery or one of its branches by an embolus, sometimes associated with infarction of the lung. |
Ontologies
Key Summary Statistics
Cases from any source
| Total |
11778 |
| Female (%) |
5928 (50%) |
| Male (%) |
5850 (50%) |
Year first recorded
Cases linked in all UK Biobank sources
Cross-source concordance
Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.
Incidence & prevalence
Baseline prevalence stratified by sex
| Female |
88.17 (81.88,94.46) |
| Male |
91.14 (84.17,98.1) |
Incidence stratified by sex
| Female |
7.91 (7.18,8.65) |
| Male |
10.04 (9.13,10.94) |
Incidence stratified by age
| Ages 40-44 |
3.23 (2.11,4.35) |
| Ages 45-49 |
4.32 (3.21,5.44) |
| Ages 50-54 |
5.55 (4.38,6.72) |
| Ages 55-59 |
7.92 (6.66,9.18) |
| Ages 60-64 |
11.47 (10.16,12.78) |
| Ages 65-69 |
15.03 (13.32,16.75) |
Period prevalence
Methods
Comparison with general population
Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)
| Population |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| UK Biobank |
45 (39,52) |
87 (80,94) |
145 (137,153) |
| CALIBER |
61 (59,63) |
100 (97,103) |
185 (181,190) |
Stratified by age and Townsend deprivation status
| Deprivation status |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| Least deprived |
34(22,51) |
67(53,83) |
128(112,145) |
| Low |
38(25,56) |
79(64,96) |
131(116,148) |
| Medium |
33(21,49) |
89(73,107) |
152(135,171) |
| High |
44(31,60) |
93(77,111) |
133(116,151) |
| Most deprived |
69(54,87) |
105(89,124) |
185(165,208) |
Stratified by age and country
| Country |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| England |
45(38,53) |
85(77,93) |
137(129,146) |
| Scotland |
32(19,52) |
92(73,115) |
172(148,199) |
| Wales |
64(39,100) |
98(73,130) |
181(151,216) |
Risk factors analysis
‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.
Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method
N=154060, Events=218
| Factor |
Level |
Hazard Ratio |
P value |
| BMI |
overweight |
0.89 (0.65, 1.23) |
0.488 |
| BMI |
obese |
1.16 (0.82, 1.63) |
0.404 |
| BMI |
underweight |
0 (0, Inf) |
0.989 |
| smoking |
previous |
1.75 (1.31, 2.35) |
0.000182 |
| smoking |
current |
2.37 (1.58, 3.55) |
3.07e-05 |
| hypertension |
yes |
1 (0.74, 1.36) |
0.997 |
Definition
| UK Biobank field id |
Description |
Code |
Value |
| 20002 |
Non-cancer illness code, self-reported |
1093 |
pulmonary embolism +/- dvt |
| 41202 |
Diagnoses - main ICD10 |
I26 |
Pulmonary embolism |
| 41204 |
Diagnoses - secondary ICD10 |
I26 |
Pulmonary embolism |
| 40001 |
Underlying (primary) cause of death: ICD10 |
I26 |
Pulmonary embolism |
| 40002 |
Contributory (secondary) causes of death: ICD10 |
I26 |
Pulmonary embolism |
| 42040 |
GP clinical event records |
14AC.00 |
H/O: pulmonary embolus |
| 42040 |
GP clinical event records |
7A09300 |
Open embolectomy of pulmonary artery |
| 42040 |
GP clinical event records |
7A09311 |
Trendelenburg pulmonary embolectomy |
| 42040 |
GP clinical event records |
7A0A100 |
Percutaneous transluminal embolectomy of pulmonary artery |
| 42040 |
GP clinical event records |
7A0B000 |
Pulmonary thromboendarterectomy |
| 42040 |
GP clinical event records |
G401000 |
Post operative pulmonary embolus |
| 42040 |
GP clinical event records |
G401100 |
Recurrent pulmonary embolism |
| 42040 |
GP clinical event records |
G401.00 |
Pulmonary embolism |
| 42040 |
GP clinical event records |
G401.12 |
Pulmonary embolus |
| 42040 |
GP clinical event records |
ZV12900 |
[V] Personal history of pulmonary embolism |
| 42040 |
GP clinical event records |
XaLgy |
Pulmonary thromboendarterectomy |
| 42040 |
GP clinical event records |
XaOYV |
Recurrent pulmonary embolism |
| 42040 |
GP clinical event records |
XaBMd |
[V] Personal history of pulmonary embolism |