| Name |
Pericardial effusion (noninflammatory) (pericardial_effusion) |
| Category |
Cardiovascular |
| Sex |
|
| Adult |
Yes |
| UUID |
f08da989-c274-4203-8d94-cdfff5de31ce |
| Definition |
A pericardium disease that is characterized by an abnormal accumulation of fluid in the pericardial cavity. |
Ontologies
Key Summary Statistics
Cases from any source
| Total |
2415 |
| Female (%) |
1071 (44%) |
| Male (%) |
1344 (56%) |
Year first recorded
Cases linked in all UK Biobank sources
Cross-source concordance
Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.
Incidence & prevalence
Baseline prevalence stratified by sex
| Female |
10.37 (8.21,12.54) |
| Male |
29.26 (25.3,33.22) |
Incidence stratified by sex
| Female |
2.2 (1.81,2.58) |
| Male |
2.62 (2.16,3.08) |
Incidence stratified by age
| Ages 40-44 |
0.8 (0.25,1.36) |
| Ages 45-49 |
1.56 (0.89,2.23) |
| Ages 50-54 |
2.09 (1.38,2.81) |
| Ages 55-59 |
1.93 (1.31,2.55) |
| Ages 60-64 |
3.19 (2.51,3.88) |
| Ages 65-69 |
3.37 (2.57,4.18) |
Period prevalence
Methods
Comparison with general population
Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)
| Population |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| UK Biobank |
18 (14,23) |
25 (21,29) |
42 (37,46) |
| CALIBER |
9 (8,10) |
17 (16,18) |
32 (30,34) |
Stratified by age and Townsend deprivation status
| Deprivation status |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| Least deprived |
16(8,28) |
17(11,26) |
43(34,53) |
| Low |
6(2,15) |
28(19,39) |
41(32,51) |
| Medium |
26(16,41) |
26(18,37) |
47(38,58) |
| High |
15(8,26) |
25(17,36) |
30(23,40) |
| Most deprived |
24(16,36) |
27(19,38) |
46(36,58) |
Stratified by age and country
| Country |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| England |
16(12,21) |
25(21,30) |
42(38,47) |
| Scotland |
11(4,27) |
26(16,39) |
46(34,61) |
| Wales |
47(25,80) |
24(12,42) |
29(18,45) |
Risk factors analysis
‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.
Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method
N=147230, Events=709
| Factor |
Level |
Hazard Ratio |
P value |
| BMI |
overweight |
1.31 (1.08, 1.58) |
0.00511 |
| BMI |
obese |
1.42 (1.15, 1.75) |
0.0011 |
| BMI |
underweight |
0 (0, Inf) |
0.982 |
| smoking |
previous |
1.11 (0.94, 1.32) |
0.217 |
| smoking |
current |
2.52 (2.07, 3.07) |
3.95e-20 |
| hypertension |
yes |
1.42 (1.21, 1.67) |
1.57e-05 |
Definition
| UK Biobank field id |
Description |
Code |
Value |
| 20002 |
Non-cancer illness code, self-reported |
1590 |
pericardial effusion |
| 41202 |
Diagnoses - main ICD10 |
I31.3 |
Pericardial effusion (noninflammatory) |
| 41204 |
Diagnoses - secondary ICD10 |
I31.3 |
Pericardial effusion (noninflammatory) |
| 40001 |
Underlying (primary) cause of death: ICD10 |
I31.3 |
Pericardial effusion (noninflammatory) |
| 40002 |
Contributory (secondary) causes of death: ICD10 |
I31.3 |
Pericardial effusion (noninflammatory) |
| 42040 |
GP clinical event records |
G50..11 |
Pericardial effusion - acute |
| 42040 |
GP clinical event records |
G533.00 |
Pericardial effusion - noninflammatory |
| 42040 |
GP clinical event records |
G534.00 |
Pericardial effusion - acute |
| 42040 |
GP clinical event records |
G536000 |
Chronic pericardial effusion |
| 42040 |
GP clinical event records |
G536.00 |
Pericardial effusion |
| 42040 |
GP clinical event records |
XaZUz |
Chronic pericardial effusion |
| 42040 |
GP clinical event records |
Xa1JD |
Pericardial effusion - acute |
| 42040 |
GP clinical event records |
XE0Up |
Acute pericarditis |
| 42040 |
GP clinical event records |
X201z |
Pericardial effusion |