Metadata

Name Peripheral neuropathies (excl. cranial nerve, carpal tunnel syndromes) (periph_neuro)
Category Neurological
Sex
Adult Yes
UUID cc164a30-04e3-4bb8-bd2d-d4fb028d3632
Definition A slowly progressive autoimmune demyelinating disease of peripheral nerves and nerve roots.

Ontologies

Disease Ontology (DOID) DOID_5213
GWAS Catalogue EFO_1000868
MeSH D011115
SNOMED-CT 128209004
FinnGen G6_POLYOTHUNS

Key Summary Statistics

Cases from any source

Total 16229
Female (%) 8403 (52%)
Male (%) 7826 (48%)

Year first recorded

periph_neuro year of first event

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Cross-sourced periph_neuro cases

Incidence & prevalence

Sex and age-stratified incidence and prevalence of periph_neuro

Baseline prevalence stratified by sex

Female 178.58 (169.67,187.5)
Male 201.17 (190.87,211.47)

Incidence stratified by sex

Female 20.83 (19.63,22.03)
Male 23.1 (21.71,24.48)

Incidence stratified by age

Ages 40-44 13.97 (11.63,16.31)
Ages 45-49 18.37 (16.06,20.68)
Ages 50-54 21.98 (19.64,24.32)
Ages 55-59 23.24 (21.05,25.42)
Ages 60-64 24.53 (22.6,26.46)
Ages 65-69 23.36 (21.2,25.51)

Period prevalence

Methods

Comparison with general population

Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)

CALIBER and UKB periph_neuro prevalence comparison for multiple age groups

Population Ages 40-49 Ages 50-59 Ages 60-69
UK Biobank 209 (195,224) 313 (300,327) 375 (363,388)
CALIBER 211 (208,215) 326 (321,331) 432 (425,439)

Stratified by age and Townsend deprivation status

Deprivation status Ages 40-49 Ages 50-59 Ages 60-69
Least deprived 205(173,241) 282(254,312) 352(326,379)
Low 204(172,240) 286(257,317) 341(316,368)
Medium 221(189,257) 306(276,337) 377(350,406)
High 177(150,207) 300(271,330) 370(341,400)
Most deprived 236(207,267) 389(357,424) 453(420,487)

Stratified by age and country

Country Ages 40-49 Ages 50-59 Ages 60-69
England 217(202,234) 312(297,328) 376(362,390)
Scotland 139(108,177) 248(216,283) 285(254,319)
Wales 238(186,300) 429(375,489) 507(456,563)

Risk factors analysis

‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.

Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method

N=153420, Events=132

Factor Level Hazard Ratio P value
BMI overweight 0.98 (0.66, 1.47) 0.928
BMI obese 1.08 (0.69, 1.7) 0.735
BMI underweight 0 (0, Inf) 0.992
smoking previous 1.16 (0.78, 1.73) 0.462
smoking current 2.27 (1.45, 3.57) 0.000355
hypertension yes 1.19 (0.76, 1.85) 0.449

Risk factors analysis forest plot

Definition

UK Biobank field id Description Code Value
20002 Non-cancer illness code, self-reported 1256 acute infective polyneuritis/guillain-barre syndrome
20002 Non-cancer illness code, self-reported 1254 peripheral nerve disorder
20002 Non-cancer illness code, self-reported 1255 peripheral neuropathy
41202 Diagnoses - main ICD10 G56.1 Other lesions of median nerve
41202 Diagnoses - main ICD10 G56.2 Lesion of ulnar nerve
41202 Diagnoses - main ICD10 G56.3 Lesion of radial nerve
41202 Diagnoses - main ICD10 G56.4 Causalgia
41202 Diagnoses - main ICD10 G56.8 Other mononeuropathies of upper limb
41202 Diagnoses - main ICD10 G56.9 Mononeuropathy of upper limb, unspecified
41202 Diagnoses - main ICD10 G57 Mononeuropathies of lower limb
41202 Diagnoses - main ICD10 G58 Other mononeuropathies
41202 Diagnoses - main ICD10 G59 Mononeuropathy in diseases classified elsewhere
41202 Diagnoses - main ICD10 G60 Hereditary and idiopathic neuropathy
41202 Diagnoses - main ICD10 G61 Inflammatory polyneuropathy
41202 Diagnoses - main ICD10 G62 Other polyneuropathies
41202 Diagnoses - main ICD10 G63 Polyneuropathy in diseases classified elsewhere
41202 Diagnoses - main ICD10 G64 Other disorders of peripheral nervous system
41202 Diagnoses - main ICD10 M14.6 Neuropathic arthropathy
41202 Diagnoses - main ICD10 M49.4 Neuropathic spondylopathy
41202 Diagnoses - main ICD10 E85.1 Neuropathic heredofamilial amyloidosis
41204 Diagnoses - secondary ICD10 G56.1 Other lesions of median nerve
41204 Diagnoses - secondary ICD10 G56.2 Lesion of ulnar nerve
41204 Diagnoses - secondary ICD10 G56.3 Lesion of radial nerve
41204 Diagnoses - secondary ICD10 G56.4 Causalgia
41204 Diagnoses - secondary ICD10 G56.8 Other mononeuropathies of upper limb
41204 Diagnoses - secondary ICD10 G56.9 Mononeuropathy of upper limb, unspecified
41204 Diagnoses - secondary ICD10 G57 Mononeuropathies of lower limb
41204 Diagnoses - secondary ICD10 G58 Other mononeuropathies
41204 Diagnoses - secondary ICD10 G59 Mononeuropathy in diseases classified elsewhere
41204 Diagnoses - secondary ICD10 G60 Hereditary and idiopathic neuropathy
41204 Diagnoses - secondary ICD10 G61 Inflammatory polyneuropathy
41204 Diagnoses - secondary ICD10 G62 Other polyneuropathies
41204 Diagnoses - secondary ICD10 G63 Polyneuropathy in diseases classified elsewhere
41204 Diagnoses - secondary ICD10 G64 Other disorders of peripheral nervous system
41204 Diagnoses - secondary ICD10 M14.6 Neuropathic arthropathy
41204 Diagnoses - secondary ICD10 M49.4 Neuropathic spondylopathy
41204 Diagnoses - secondary ICD10 E85.1 Neuropathic heredofamilial amyloidosis
40001 Underlying (primary) cause of death: ICD10 G56.1 Other lesions of median nerve
40001 Underlying (primary) cause of death: ICD10 G56.2 Lesion of ulnar nerve
40001 Underlying (primary) cause of death: ICD10 G56.3 Lesion of radial nerve
40001 Underlying (primary) cause of death: ICD10 G56.4 Causalgia
40001 Underlying (primary) cause of death: ICD10 G56.8 Other mononeuropathies of upper limb
40001 Underlying (primary) cause of death: ICD10 G56.9 Mononeuropathy of upper limb, unspecified
40001 Underlying (primary) cause of death: ICD10 G57 Mononeuropathies of lower limb
40001 Underlying (primary) cause of death: ICD10 G58 Other mononeuropathies
40001 Underlying (primary) cause of death: ICD10 G59 Mononeuropathy in diseases classified elsewhere
40001 Underlying (primary) cause of death: ICD10 G60 Hereditary and idiopathic neuropathy
40001 Underlying (primary) cause of death: ICD10 G61 Inflammatory polyneuropathy
40001 Underlying (primary) cause of death: ICD10 G62 Other polyneuropathies
40001 Underlying (primary) cause of death: ICD10 G63 Polyneuropathy in diseases classified elsewhere
40001 Underlying (primary) cause of death: ICD10 G64 Other disorders of peripheral nervous system
40001 Underlying (primary) cause of death: ICD10 M14.6 Neuropathic arthropathy
40001 Underlying (primary) cause of death: ICD10 M49.4 Neuropathic spondylopathy
40001 Underlying (primary) cause of death: ICD10 E85.1 Neuropathic heredofamilial amyloidosis
40002 Contributory (secondary) causes of death: ICD10 G56.1 Other lesions of median nerve
40002 Contributory (secondary) causes of death: ICD10 G56.2 Lesion of ulnar nerve
40002 Contributory (secondary) causes of death: ICD10 G56.3 Lesion of radial nerve
40002 Contributory (secondary) causes of death: ICD10 G56.4 Causalgia
40002 Contributory (secondary) causes of death: ICD10 G56.8 Other mononeuropathies of upper limb
40002 Contributory (secondary) causes of death: ICD10 G56.9 Mononeuropathy of upper limb, unspecified
40002 Contributory (secondary) causes of death: ICD10 G57 Mononeuropathies of lower limb
40002 Contributory (secondary) causes of death: ICD10 G58 Other mononeuropathies
40002 Contributory (secondary) causes of death: ICD10 G59 Mononeuropathy in diseases classified elsewhere
40002 Contributory (secondary) causes of death: ICD10 G60 Hereditary and idiopathic neuropathy
40002 Contributory (secondary) causes of death: ICD10 G61 Inflammatory polyneuropathy
40002 Contributory (secondary) causes of death: ICD10 G62 Other polyneuropathies
40002 Contributory (secondary) causes of death: ICD10 G63 Polyneuropathy in diseases classified elsewhere
40002 Contributory (secondary) causes of death: ICD10 G64 Other disorders of peripheral nervous system
40002 Contributory (secondary) causes of death: ICD10 M14.6 Neuropathic arthropathy
40002 Contributory (secondary) causes of death: ICD10 M49.4 Neuropathic spondylopathy
40002 Contributory (secondary) causes of death: ICD10 E85.1 Neuropathic heredofamilial amyloidosis
42040 GP clinical event records A531300 Postherpetic polyneuropathy
42040 GP clinical event records A72x100 Mumps polyneuropathy
42040 GP clinical event records C106.12 Diabetes mellitus with neuropathy
42040 GP clinical event records C106.13 Diabetes mellitus with polyneuropathy
42040 GP clinical event records C108B00 Insulin dependent diabetes mellitus with mononeuropathy
42040 GP clinical event records C108B11 Type I diabetes mellitus with mononeuropathy
42040 GP clinical event records C108C00 Insulin dependent diabetes mellitus with polyneuropathy
42040 GP clinical event records C108J00 Insulin dependent diab mell with neuropathic arthropathy
42040 GP clinical event records C108J11 Type I diabetes mellitus with neuropathic arthropathy
42040 GP clinical event records C108J12 Type 1 diabetes mellitus with neuropathic arthropathy
42040 GP clinical event records C109A00 Non-insulin dependent diabetes mellitus with mononeuropathy
42040 GP clinical event records C109A11 Type II diabetes mellitus with mononeuropathy
42040 GP clinical event records C109B00 Non-insulin dependent diabetes mellitus with polyneuropathy
42040 GP clinical event records C109B11 Type II diabetes mellitus with polyneuropathy
42040 GP clinical event records C109B12 Type 2 diabetes mellitus with polyneuropathy
42040 GP clinical event records C109H00 Non-insulin dependent d m with neuropathic arthropathy
42040 GP clinical event records C109H11 Type II diabetes mellitus with neuropathic arthropathy
42040 GP clinical event records C109H12 Type 2 diabetes mellitus with neuropathic arthropathy
42040 GP clinical event records C10EB00 Type 1 diabetes mellitus with mononeuropathy
42040 GP clinical event records C10EC00 Type 1 diabetes mellitus with polyneuropathy
42040 GP clinical event records C10EC11 Type I diabetes mellitus with polyneuropathy
42040 GP clinical event records C10EC12 Insulin dependent diabetes mellitus with polyneuropathy
42040 GP clinical event records C10EJ00 Type 1 diabetes mellitus with neuropathic arthropathy
42040 GP clinical event records C10FA00 Type 2 diabetes mellitus with mononeuropathy
42040 GP clinical event records C10FA11 Type II diabetes mellitus with mononeuropathy
42040 GP clinical event records C10FB00 Type 2 diabetes mellitus with polyneuropathy
42040 GP clinical event records C10FB11 Type II diabetes mellitus with polyneuropathy
42040 GP clinical event records C10FH00 Type 2 diabetes mellitus with neuropathic arthropathy
42040 GP clinical event records C10FH11 Type II diabetes mellitus with neuropathic arthropathy
42040 GP clinical event records C34y400 Gouty neuritis
42040 GP clinical event records C373200 Familial neuropathic amyloid
42040 GP clinical event records C373K13 Familial amyloid polyneuropathy type III
42040 GP clinical event records E011100 Korsakov’s alcoholic psychosis with peripheral neuritis
42040 GP clinical event records F341000 Median nerve neuritis
42040 GP clinical event records F341100 Median nerve compression in forearm
42040 GP clinical event records F341.00 Other median nerve lesions
42040 GP clinical event records F341z00 Median nerve lesions NOS
42040 GP clinical event records F342000 Cubital tunnel syndrome
42040 GP clinical event records F342100 Tardy ulnar nerve palsy
42040 GP clinical event records F342200 Canal of Guyon compression
42040 GP clinical event records F342300 Ulnar nerve entrapment
42040 GP clinical event records F342400 Ulnar neuropathy
42040 GP clinical event records F342.00 Ulnar nerve lesions
42040 GP clinical event records F342.11 Neuritis ulnar nerve
42040 GP clinical event records F342z00 Ulnar nerve lesion NOS
42040 GP clinical event records F343000 Acute radial nerve palsy
42040 GP clinical event records F343100 Sensory branch of radial nerve lesion
42040 GP clinical event records F343200 Posterior interosseous nerve lesion
42040 GP clinical event records F343.00 Radial nerve lesions
42040 GP clinical event records F343z00 Radial nerve lesion NOS
42040 GP clinical event records F344.00 Causalgia
42040 GP clinical event records F345000 Diabetic mononeuritis multiplex
42040 GP clinical event records F345.00 Mononeuritis multiplex
42040 GP clinical event records F346.00 Median nerve entrapment
42040 GP clinical event records F34..00 Mononeuritis of upper limb and mononeuritis multiplex
42040 GP clinical event records F34y.00 Other upper limb mononeuritis
42040 GP clinical event records F34z.00 Mononeuritis upper limb NOS
42040 GP clinical event records F350.00 Sciatic nerve lesion
42040 GP clinical event records F351.00 Meralgia paraesthetica
42040 GP clinical event records F352.00 Femoral nerve lesions
42040 GP clinical event records F353.00 Common peroneal nerve lesion
42040 GP clinical event records F353.11 Lateral popliteal nerve lesion
42040 GP clinical event records F354.00 Tibial nerve lesion
42040 GP clinical event records F354.11 Medial popliteal nerve lesion
42040 GP clinical event records F355.00 Tarsal tunnel syndrome
42040 GP clinical event records F356000 Morton’s metatarsalgia
42040 GP clinical event records F356100 Morton’s neuralgia
42040 GP clinical event records F356.00 Plantar nerve lesion
42040 GP clinical event records F356z00 Plantar nerve lesion NOS
42040 GP clinical event records F357.00 Superficial peroneal nerve lesion
42040 GP clinical event records F358.00 Deep peroneal nerve lesion
42040 GP clinical event records F35..00 Mononeuritis lower limb
42040 GP clinical event records F35x.00 Other mononeuritis lower limb
42040 GP clinical event records F35y.00 Unspecified mononeuritis lower limb
42040 GP clinical event records F35z000 Diabetic mononeuritis NOS
42040 GP clinical event records F35z.00 Mononeuritis of unspecified site NOS
42040 GP clinical event records F35z.11 Peripheral neuropathy - hereditary or idiopathic
42040 GP clinical event records F360000 Dejerine-Sottas disease
42040 GP clinical event records F360.00 Hereditary peripheral neuropathy
42040 GP clinical event records F360z00 Hereditary peripheral neuropathy NOS
42040 GP clinical event records F361000 Charcot-Marie-Tooth disease
42040 GP clinical event records F361011 Charcot’s atrophy
42040 GP clinical event records F361012 Charcot-Marie-Tooth syndrome
42040 GP clinical event records F361.00 Peroneal muscular atrophy
42040 GP clinical event records F361z00 Peroneal muscular atrophy NOS
42040 GP clinical event records F362.00 Hereditary sensory neuropathy
42040 GP clinical event records F363.00 Refsum’s disease
42040 GP clinical event records F364.00 Idiopathic progressive polyneuropathy
42040 GP clinical event records F365.00 Neuropathy in association with hereditary ataxia
42040 GP clinical event records F366.00 Polyneuropathy
42040 GP clinical event records F367.00 Peripheral neuropathy
42040 GP clinical event records F368000 Hereditary motor and sensory neuropathy type I
42040 GP clinical event records F368100 Hereditary motor and sensory neuropathy type II
42040 GP clinical event records F368200 Hereditary motor and sensory neuropathy type III
42040 GP clinical event records F368.00 Hereditary motor and sensory neuropathy
42040 GP clinical event records F36..00 Hereditary and idiopathic peripheral neuropathy
42040 GP clinical event records F36y.00 Other idiopathic peripheral neuropathy
42040 GP clinical event records F36yz00 Other idiopathic peripheral neuropathy NOS
42040 GP clinical event records F36z.00 Hereditary or idiopathic peripheral neuropathy NOS
42040 GP clinical event records F370000 Guillain-Barre syndrome
42040 GP clinical event records F370100 Postinfectious polyneuritis
42040 GP clinical event records F370200 Miller-Fisher syndrome
42040 GP clinical event records F370.00 Acute infective polyneuritis
42040 GP clinical event records F370z00 Acute infective polyneuritis NOS
42040 GP clinical event records F371000 Polyneuropathy in disseminated lupus erythematosus
42040 GP clinical event records F371100 Polyneuropathy in polyarteritis nodosa
42040 GP clinical event records F371200 Polyneuropathy in rheumatoid arthritis
42040 GP clinical event records F371.00 Polyneuropathy in collagen vascular disease
42040 GP clinical event records F371z00 Polyneuropathy in collagen vascular disease NOS
42040 GP clinical event records F372000 Acute painful diabetic neuropathy
42040 GP clinical event records F372100 Chronic painful diabetic neuropathy
42040 GP clinical event records F372200 Asymptomatic diabetic neuropathy
42040 GP clinical event records F372.00 Polyneuropathy in diabetes
42040 GP clinical event records F372.11 Diabetic polyneuropathy
42040 GP clinical event records F372.12 Diabetic neuropathy
42040 GP clinical event records F373.00 Polyneuropathy in malignant disease
42040 GP clinical event records F374000 Polyneuropathy in amyloidosis
42040 GP clinical event records F374100 Polyneuropathy in beriberi
42040 GP clinical event records F374200 Polyneuropathy in vitamin B deficiency
42040 GP clinical event records F374300 Polyneuropathy in diphtheria
42040 GP clinical event records F374400 Polyneuropathy in herpes zoster
42040 GP clinical event records F374500 Polyneuropathy in hypoglycaemia
42040 GP clinical event records F374600 Polyneuropathy in mumps
42040 GP clinical event records F374800 Polyneuropathy in porphyria
42040 GP clinical event records F374900 Polyneuropathy in sarcoidosis
42040 GP clinical event records F374A00 Polyneuropathy in uraemia
42040 GP clinical event records F374.00 Polyneuropathy in disease EC
42040 GP clinical event records F374z00 Polyneuropathy in disease NOS
42040 GP clinical event records F375.00 Alcoholic polyneuropathy
42040 GP clinical event records F376.00 Polyneuropathy due to drugs
42040 GP clinical event records F377.00 Other toxic agent polyneuropathy
42040 GP clinical event records F378.00 Intercostal neuropathy
42040 GP clinical event records F37..00 Inflammatory and toxic neuropathy
42040 GP clinical event records F37..11 Toxic neuropathy
42040 GP clinical event records F37X.00 Inflammatory polyneuropathy, unspecified
42040 GP clinical event records F37y000 Serum neuropathy
42040 GP clinical event records F37y100 Axonal sensorimotor neuropathy
42040 GP clinical event records F37y.00 Other toxic or inflammatory neuropathy
42040 GP clinical event records F37z.00 Toxic or inflammatory neuropathy NOS
42040 GP clinical event records F37z.11 Polyneuropathy unspecified
42040 GP clinical event records F3y0.00 Diabetic mononeuropathy
42040 GP clinical event records F3y..00 Other specified disorders of peripheral nervous system
42040 GP clinical event records F3z..00 Peripheral nervous system disorder NOS
42040 GP clinical event records Fyu1300 [X]Paraneoplastic neuromyopathy and neuropathy
42040 GP clinical event records Fyu6900 [X]Other lesions of median nerve
42040 GP clinical event records Fyu6A00 [X]Other mononeuropathies of upper limb
42040 GP clinical event records Fyu6B00 [X]Other mononeuropathies of lower limb
42040 GP clinical event records Fyu6C00 [X]Other specified mononeuropathies
42040 GP clinical event records Fyu6D00 [X]Other mononeuropathies in diseases classified elsewhere
42040 GP clinical event records Fyu7000 [X]Other hereditary and idiopathic neuropathies
42040 GP clinical event records Fyu7100 [X]Other inflammatory polyneuropathies
42040 GP clinical event records Fyu7200 [X]Other specified polyneuropathies
42040 GP clinical event records Fyu7500 [X]Polyneuropathy/other endocrine+metabolic diseases CE
42040 GP clinical event records Fyu7800 [X]Polyneuropathy/other musculoskeletal disorders CE
42040 GP clinical event records Fyu7B00 [X]Inflammatory polyneuropathy, unspecified
42040 GP clinical event records Fyu7C00 [X] Polyneuropathy, unspecified
42040 GP clinical event records Fyu7.00 [X]Polyneuropathies & other disord of peripheral nerv syst
42040 GP clinical event records M271100 Neuropathic diabetic ulcer - foot
42040 GP clinical event records M271700 Neuropathic foot ulcer
42040 GP clinical event records N035.00 Neuropathic arthropathy
42040 GP clinical event records N035.12 Neuropathic arthritis
42040 GP clinical event records N11y200 Neuropathic spondylopathy
42040 GP clinical event records N134.14 Ulnar neuritis
42040 GP clinical event records SD72200 Neuropathic foot blister
42040 GP clinical event records X00C5 Intercostal neuropathy
42040 GP clinical event records X00AA Hereditary motor and sensory neuropathy type II
42040 GP clinical event records F3600 Hereditary motor and sensory neuropathy type III
42040 GP clinical event records X00A9 Hereditary motor and sensory neuropathy type I
42040 GP clinical event records X00CH Axonal sensorimotor neuropathy
42040 GP clinical event records X00Al Diabetic mononeuropathy
42040 GP clinical event records XE15h Ulnar nerve lesions
42040 GP clinical event records XE10H Diabetes mellitus with neurological manifestation
42040 GP clinical event records F3610 Hereditary motor and sensory neuropathy
42040 GP clinical event records X75at Median nerve entrapment
42040 GP clinical event records XE2sp Neuropathic arthropathy
42040 GP clinical event records Xa0Ks Ulnar nerve entrapment
42040 GP clinical event records XE15i Mononeuritis of unspecified site NOS
42040 GP clinical event records XaIrg Ulnar neuropathy
42040 GP clinical event records XE15j Inflammatory and toxic neuropathy
42040 GP clinical event records XE15m Toxic or inflammatory neuropathy NOS
42040 GP clinical event records XE1F5 Brachial (cervical) neuritis
42040 GP clinical event records X50Bj Neuropathic foot ulcer