Peritonitis

Metadata

Name	Peritonitis (peritonitis)
Category	Digestive
Sex
Adult	Yes
UUID	179c5252-5585-445b-a577-4786e2accd05
Definition	Inflammation of the peritoneum due to infection by bacteria or fungi.

Ontologies

Disease Ontology (DOID)	DOID_8283
GWAS Catalogue	EFO_0008588
MeSH	D010538
SNOMED-CT	48661000
FinnGen	K11_PERITONITIS

Key Summary Statistics

Cases from any source

Total	7220
Female (%)	3541 (49%)
Male (%)	3679 (51%)

Year first recorded

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Incidence & prevalence

Baseline prevalence stratified by sex

Female	58.7 (53.56,63.84)
Male	77.14 (70.72,83.55)

Incidence stratified by sex

Female	4.92 (4.34,5.49)
Male	6.16 (5.45,6.86)

Incidence stratified by age

Ages 40-44	3.23 (2.11,4.35)
Ages 45-49	3.43 (2.44,4.42)
Ages 50-54	5.16 (4.04,6.28)
Ages 55-59	4.98 (3.98,5.98)
Ages 60-64	6.31 (5.34,7.28)
Ages 65-69	7.66 (6.44,8.88)

Period prevalence

Methods

Comparison with general population

Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)

Population	Ages 40-49	Ages 50-59	Ages 60-69
UK Biobank	47 (40,54)	66 (60,72)	83 (77,89)
CALIBER	52 (50,54)	77 (74,80)	110 (107,114)

Stratified by age and Townsend deprivation status

Deprivation status	Ages 40-49	Ages 50-59	Ages 60-69
Least deprived	38(25,55)	54(42,68)	70(59,83)
Low	41(27,59)	43(33,56)	82(70,96)
Medium	38(25,55)	64(50,79)	70(59,84)
High	44(31,60)	78(63,94)	89(75,104)
Most deprived	66(51,84)	89(73,106)	108(92,126)

Stratified by age and country

Country	Ages 40-49	Ages 50-59	Ages 60-69
England	46(39,54)	67(60,74)	81(75,88)
Scotland	49(31,73)	64(48,83)	97(79,118)
Wales	53(30,88)	60(40,85)	79(59,103)

Risk factors analysis

‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.

Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method

N=153646, Events=402

Factor	Level	Hazard Ratio	P value
BMI	overweight	1.07 (0.82, 1.39)	0.637
BMI	obese	2.13 (1.65, 2.77)	1.06e-08
BMI	underweight	0 (0, Inf)	0.986
smoking	previous	1.48 (1.19, 1.85)	0.000498
smoking	current	2.47 (1.87, 3.26)	1.43e-10
hypertension	yes	2.21 (1.8, 2.72)	5.76e-14

Definition

UK Biobank field id	Description	Code	Value
20002	Non-cancer illness code, self-reported	1600	bowel / intestinal perforation
20002	Non-cancer illness code, self-reported	1190	peritonitis
41202	Diagnoses - main ICD10	K25.1	Gastric ulcer - Acute with perforation
41202	Diagnoses - main ICD10	K25.2	Gastric ulcer - Acute with both haemorrhage and perforation
41202	Diagnoses - main ICD10	K25.5	Gastric ulcer - Chronic or unspecified with perforation
41202	Diagnoses - main ICD10	K25.6	Gastric ulcer - Chronic or unspecified with both haemorrhage and perforation
41202	Diagnoses - main ICD10	K26.1	Duodenal ulcer - Acute with perforation
41202	Diagnoses - main ICD10	K26.2	Duodenal ulcer - Acute with both haemorrhage and perforation
41202	Diagnoses - main ICD10	K26.5	Duodenal ulcer - Chronic or unspecified with perforation
41202	Diagnoses - main ICD10	K26.6	Duodenal ulcer - Chronic or unspecified with both haemorrhage and perforation
41202	Diagnoses - main ICD10	K27.1	Peptic ulcer, site unspecified - Acute with perforation
41202	Diagnoses - main ICD10	K27.2	Peptic ulcer, site unspecified - Acute with both haemorrhage and perforation
41202	Diagnoses - main ICD10	K27.5	Peptic ulcer, site unspecified - Chronic or unspecified with perforation
41202	Diagnoses - main ICD10	K27.6	Peptic ulcer, site unspecified - Chronic or unspecified with both haemorrhage and perforation
41202	Diagnoses - main ICD10	K28.1	Gastrojejunal ulcer - Acute with perforation
41202	Diagnoses - main ICD10	K28.2	Gastrojejunal ulcer - Acute with both haemorrhage and perforation
41202	Diagnoses - main ICD10	K28.5	Gastrojejunal ulcer - Chronic or unspecified with perforation
41202	Diagnoses - main ICD10	K28.6	Gastrojejunal ulcer - Chronic or unspecified with both haemorrhage and perforation
41202	Diagnoses - main ICD10	K35.2	Acute appendicitis with generalized peritonitis
41202	Diagnoses - main ICD10	K35.3	Acute appendicitis with localized peritonitis
41202	Diagnoses - main ICD10	K57.0	Diverticular disease of small intestine with perforation and abscess
41202	Diagnoses - main ICD10	K57.2	Diverticular disease of large intestine with perforation and abscess
41202	Diagnoses - main ICD10	K57.4	Diverticular disease of both small and large intestine with perforation and abscess
41202	Diagnoses - main ICD10	K57.8	Diverticular disease of intestine, part unspecified, with perforation and abscess
41202	Diagnoses - main ICD10	K63.1	Perforation of intestine (nontraumatic)
41202	Diagnoses - main ICD10	K65	Peritonitis
41202	Diagnoses - main ICD10	K67	Disorders of peritoneum in infectious diseases classified elsewhere
41204	Diagnoses - secondary ICD10	K25.1	Gastric ulcer - Acute with perforation
41204	Diagnoses - secondary ICD10	K25.2	Gastric ulcer - Acute with both haemorrhage and perforation
41204	Diagnoses - secondary ICD10	K25.5	Gastric ulcer - Chronic or unspecified with perforation
41204	Diagnoses - secondary ICD10	K25.6	Gastric ulcer - Chronic or unspecified with both haemorrhage and perforation
41204	Diagnoses - secondary ICD10	K26.1	Duodenal ulcer - Acute with perforation
41204	Diagnoses - secondary ICD10	K26.2	Duodenal ulcer - Acute with both haemorrhage and perforation
41204	Diagnoses - secondary ICD10	K26.5	Duodenal ulcer - Chronic or unspecified with perforation
41204	Diagnoses - secondary ICD10	K26.6	Duodenal ulcer - Chronic or unspecified with both haemorrhage and perforation
41204	Diagnoses - secondary ICD10	K27.1	Peptic ulcer, site unspecified - Acute with perforation
41204	Diagnoses - secondary ICD10	K27.2	Peptic ulcer, site unspecified - Acute with both haemorrhage and perforation
41204	Diagnoses - secondary ICD10	K27.5	Peptic ulcer, site unspecified - Chronic or unspecified with perforation
41204	Diagnoses - secondary ICD10	K27.6	Peptic ulcer, site unspecified - Chronic or unspecified with both haemorrhage and perforation
41204	Diagnoses - secondary ICD10	K28.1	Gastrojejunal ulcer - Acute with perforation
41204	Diagnoses - secondary ICD10	K28.2	Gastrojejunal ulcer - Acute with both haemorrhage and perforation
41204	Diagnoses - secondary ICD10	K28.5	Gastrojejunal ulcer - Chronic or unspecified with perforation
41204	Diagnoses - secondary ICD10	K28.6	Gastrojejunal ulcer - Chronic or unspecified with both haemorrhage and perforation
41204	Diagnoses - secondary ICD10	K35.2	Acute appendicitis with generalized peritonitis
41204	Diagnoses - secondary ICD10	K35.3	Acute appendicitis with localized peritonitis
41204	Diagnoses - secondary ICD10	K57.0	Diverticular disease of small intestine with perforation and abscess
41204	Diagnoses - secondary ICD10	K57.2	Diverticular disease of large intestine with perforation and abscess
41204	Diagnoses - secondary ICD10	K57.4	Diverticular disease of both small and large intestine with perforation and abscess
41204	Diagnoses - secondary ICD10	K57.8	Diverticular disease of intestine, part unspecified, with perforation and abscess
41204	Diagnoses - secondary ICD10	K63.1	Perforation of intestine (nontraumatic)
41204	Diagnoses - secondary ICD10	K65	Peritonitis
41204	Diagnoses - secondary ICD10	K67	Disorders of peritoneum in infectious diseases classified elsewhere
41200	Operative procedures - main OPCS4	G35.1	Closure of perforated ulcer of stomach
41200	Operative procedures - main OPCS4	G36.2	Closure of perforation of stomach NEC
41200	Operative procedures - main OPCS4	G41.2	Repair of perforation of pylorus
41200	Operative procedures - main OPCS4	G52.1	Closure of perforated ulcer of duodenum
41200	Operative procedures - main OPCS4	G53.2	Closure of perforation of duodenum NEC
41200	Operative procedures - main OPCS4	G63.3	Closure of perforation of jejunum
41200	Operative procedures - main OPCS4	G78.4	Closure of perforation of ileum
41200	Operative procedures - main OPCS4	J20.3	Repair of perforation of gall bladder
41210	Operative procedures - secondary OPCS4	G35.1	G35.1
41210	Operative procedures - secondary OPCS4	G36.2	G36.2
41210	Operative procedures - secondary OPCS4	G41.2	G41.2
41210	Operative procedures - secondary OPCS4	G52.1	G52.1
41210	Operative procedures - secondary OPCS4	G53.2	G53.2
41210	Operative procedures - secondary OPCS4	G63.3	G63.3
41210	Operative procedures - secondary OPCS4	G78.4	G78.4
41210	Operative procedures - secondary OPCS4	J20.3	J20.3
40001	Underlying (primary) cause of death: ICD10	K25.1	Gastric ulcer - Acute with perforation
40001	Underlying (primary) cause of death: ICD10	K25.2	Gastric ulcer - Acute with both haemorrhage and perforation
40001	Underlying (primary) cause of death: ICD10	K25.5	Gastric ulcer - Chronic or unspecified with perforation
40001	Underlying (primary) cause of death: ICD10	K25.6	Gastric ulcer - Chronic or unspecified with both haemorrhage and perforation
40001	Underlying (primary) cause of death: ICD10	K26.1	Duodenal ulcer - Acute with perforation
40001	Underlying (primary) cause of death: ICD10	K26.2	Duodenal ulcer - Acute with both haemorrhage and perforation
40001	Underlying (primary) cause of death: ICD10	K26.5	Duodenal ulcer - Chronic or unspecified with perforation
40001	Underlying (primary) cause of death: ICD10	K26.6	Duodenal ulcer - Chronic or unspecified with both haemorrhage and perforation
40001	Underlying (primary) cause of death: ICD10	K27.1	Peptic ulcer, site unspecified - Acute with perforation
40001	Underlying (primary) cause of death: ICD10	K27.2	Peptic ulcer, site unspecified - Acute with both haemorrhage and perforation
40001	Underlying (primary) cause of death: ICD10	K27.5	Peptic ulcer, site unspecified - Chronic or unspecified with perforation
40001	Underlying (primary) cause of death: ICD10	K27.6	Peptic ulcer, site unspecified - Chronic or unspecified with both haemorrhage and perforation
40001	Underlying (primary) cause of death: ICD10	K28.1	Gastrojejunal ulcer - Acute with perforation
40001	Underlying (primary) cause of death: ICD10	K28.2	Gastrojejunal ulcer - Acute with both haemorrhage and perforation
40001	Underlying (primary) cause of death: ICD10	K28.5	Gastrojejunal ulcer - Chronic or unspecified with perforation
40001	Underlying (primary) cause of death: ICD10	K28.6	Gastrojejunal ulcer - Chronic or unspecified with both haemorrhage and perforation
40001	Underlying (primary) cause of death: ICD10	K35.2	Acute appendicitis with generalized peritonitis
40001	Underlying (primary) cause of death: ICD10	K35.3	Acute appendicitis with localized peritonitis
40001	Underlying (primary) cause of death: ICD10	K57.0	Diverticular disease of small intestine with perforation and abscess
40001	Underlying (primary) cause of death: ICD10	K57.2	Diverticular disease of large intestine with perforation and abscess
40001	Underlying (primary) cause of death: ICD10	K57.4	Diverticular disease of both small and large intestine with perforation and abscess
40001	Underlying (primary) cause of death: ICD10	K57.8	Diverticular disease of intestine, part unspecified, with perforation and abscess
40001	Underlying (primary) cause of death: ICD10	K63.1	Perforation of intestine (nontraumatic)
40001	Underlying (primary) cause of death: ICD10	K65	Peritonitis
40001	Underlying (primary) cause of death: ICD10	K67	Disorders of peritoneum in infectious diseases classified elsewhere
40002	Contributory (secondary) causes of death: ICD10	K25.1	Gastric ulcer - Acute with perforation
40002	Contributory (secondary) causes of death: ICD10	K25.2	Gastric ulcer - Acute with both haemorrhage and perforation
40002	Contributory (secondary) causes of death: ICD10	K25.5	Gastric ulcer - Chronic or unspecified with perforation
40002	Contributory (secondary) causes of death: ICD10	K25.6	Gastric ulcer - Chronic or unspecified with both haemorrhage and perforation
40002	Contributory (secondary) causes of death: ICD10	K26.1	Duodenal ulcer - Acute with perforation
40002	Contributory (secondary) causes of death: ICD10	K26.2	Duodenal ulcer - Acute with both haemorrhage and perforation
40002	Contributory (secondary) causes of death: ICD10	K26.5	Duodenal ulcer - Chronic or unspecified with perforation
40002	Contributory (secondary) causes of death: ICD10	K26.6	Duodenal ulcer - Chronic or unspecified with both haemorrhage and perforation
40002	Contributory (secondary) causes of death: ICD10	K27.1	Peptic ulcer, site unspecified - Acute with perforation
40002	Contributory (secondary) causes of death: ICD10	K27.2	Peptic ulcer, site unspecified - Acute with both haemorrhage and perforation
40002	Contributory (secondary) causes of death: ICD10	K27.5	Peptic ulcer, site unspecified - Chronic or unspecified with perforation
40002	Contributory (secondary) causes of death: ICD10	K27.6	Peptic ulcer, site unspecified - Chronic or unspecified with both haemorrhage and perforation
40002	Contributory (secondary) causes of death: ICD10	K28.1	Gastrojejunal ulcer - Acute with perforation
40002	Contributory (secondary) causes of death: ICD10	K28.2	Gastrojejunal ulcer - Acute with both haemorrhage and perforation
40002	Contributory (secondary) causes of death: ICD10	K28.5	Gastrojejunal ulcer - Chronic or unspecified with perforation
40002	Contributory (secondary) causes of death: ICD10	K28.6	Gastrojejunal ulcer - Chronic or unspecified with both haemorrhage and perforation
40002	Contributory (secondary) causes of death: ICD10	K35.2	Acute appendicitis with generalized peritonitis
40002	Contributory (secondary) causes of death: ICD10	K35.3	Acute appendicitis with localized peritonitis
40002	Contributory (secondary) causes of death: ICD10	K57.0	Diverticular disease of small intestine with perforation and abscess
40002	Contributory (secondary) causes of death: ICD10	K57.2	Diverticular disease of large intestine with perforation and abscess
40002	Contributory (secondary) causes of death: ICD10	K57.4	Diverticular disease of both small and large intestine with perforation and abscess
40002	Contributory (secondary) causes of death: ICD10	K57.8	Diverticular disease of intestine, part unspecified, with perforation and abscess
40002	Contributory (secondary) causes of death: ICD10	K63.1	Perforation of intestine (nontraumatic)
40002	Contributory (secondary) causes of death: ICD10	K65	Peritonitis
40002	Contributory (secondary) causes of death: ICD10	K67	Disorders of peritoneum in infectious diseases classified elsewhere
42040	GP clinical event records	7618100.0	Closure of perforation of stomach NEC
42040	GP clinical event records	761C100	Repair of perforation of pylorus
42040	GP clinical event records	761J000	Closure of perforated gastric ulcer
42040	GP clinical event records	7623100.0	Closure of perforation of duodenum NEC
42040	GP clinical event records	7627000.0	Closure of perforated duodenal ulcer
42040	GP clinical event records	7635200.0	Closure of perforation of jejunum
42040	GP clinical event records	7648300.0	Closure of perforation of ileum
42040	GP clinical event records	773C600	Closure of perforated bowel ulcer NEC
42040	GP clinical event records	7812200.0	Repair of perforation of gall bladder
42040	GP clinical event records	A140.00	Tuberculous peritonitis
42040	GP clinical event records	A32y200	Diphtheritic peritonitis
42040	GP clinical event records	A98y500	Gonococcal peritonitis
42040	GP clinical event records	J110200	Acute gastric ulcer with perforation
42040	GP clinical event records	J110300	Acute gastric ulcer with haemorrhage and perforation
42040	GP clinical event records	J111200	Chronic gastric ulcer with perforation
42040	GP clinical event records	J111211	Perforated chronic gastric ulcer
42040	GP clinical event records	J111300	Chronic gastric ulcer with haemorrhage and perforation
42040	GP clinical event records	J11y200	Unspecified gastric ulcer with perforation
42040	GP clinical event records	J11yy00	Unspec gastric ulcer; unspec haemorrhage and/or perforation
42040	GP clinical event records	J120200	Acute duodenal ulcer with perforation
42040	GP clinical event records	J120300	Acute duodenal ulcer with haemorrhage and perforation
42040	GP clinical event records	J121200	Chronic duodenal ulcer with perforation
42040	GP clinical event records	J121211	Perforated chronic duodenal ulcer
42040	GP clinical event records	J121300	Chronic duodenal ulcer with haemorrhage and perforation
42040	GP clinical event records	J12y200	Unspecified duodenal ulcer with perforation
42040	GP clinical event records	J12y300	Unspecified duodenal ulcer with haemorrhage and perforation
42040	GP clinical event records	J12yy00	Unspec duodenal ulcer; unspec haemorrhage and/or perforation
42040	GP clinical event records	J130200	Acute peptic ulcer with perforation
42040	GP clinical event records	J130300	Acute peptic ulcer with haemorrhage and perforation
42040	GP clinical event records	J131200	Chronic peptic ulcer with perforation
42040	GP clinical event records	J13y200	Unspecified peptic ulcer with perforation
42040	GP clinical event records	J13y300	Unspecified peptic ulcer with haemorrhage and perforation
42040	GP clinical event records	J140200	Acute gastrojejunal ulcer with perforation
42040	GP clinical event records	J140300	Acute gastrojejunal ulcer with haemorrhage and perforation
42040	GP clinical event records	J141300	Chronic gastrojejunal ulcer with haemorrhage and perforation
42040	GP clinical event records	J14y200	Unspecified gastrojejunal ulcer with perforation
42040	GP clinical event records	J179.00	Perforation of stomach
42040	GP clinical event records	J200.00	Acute appendicitis with peritonitis
42040	GP clinical event records	J201.00	Acute appendicitis with appendix abscess
42040	GP clinical event records	J201.11	Abscess of appendix
42040	GP clinical event records	J201.12	Appendix abscess
42040	GP clinical event records	J203.00	Acute appendicitis with generalised peritonitis
42040	GP clinical event records	J204.00	Acute appendicitis with localised peritonitis
42040	GP clinical event records	J20z100	Acute gangrenous appendicitis
42040	GP clinical event records	J512000	Perforated diverticulum of duodenum
42040	GP clinical event records	J512100	Perforated diverticulum of jejunum
42040	GP clinical event records	J512200	Perforated diverticulum of ileum
42040	GP clinical event records	J512300	Perforated diverticulum of small intestine unspecified
42040	GP clinical event records	J512400	Perforated diverticulum of small intestine NOS
42040	GP clinical event records	J512500	Perforated diverticulum of colon
42040	GP clinical event records	J512600	Perforated diverticulum of large intestine unspecified
42040	GP clinical event records	J512700	Perforated diverticulum of large intestine NOS
42040	GP clinical event records	J512800	Divertic disease/both sml+lge intestin with perforat+abscess
42040	GP clinical event records	J512.00	Perforated diverticulum
42040	GP clinical event records	J512y00	Perforated diverticulum unspecified
42040	GP clinical event records	J512z00	Perforated diverticulum of intestine NOS
42040	GP clinical event records	J550000	Peritonitis - gonococcal
42040	GP clinical event records	J550200	Peritonitis - tuberculous
42040	GP clinical event records	J550300	Peritonitis - bacterial
42040	GP clinical event records	J550311	Bacterial peritonitis
42040	GP clinical event records	J550400	Chlamydial peritonitis
42040	GP clinical event records	J550.00	Peritonitis in infectious diseases EC
42040	GP clinical event records	J550z00	Peritonitis in infectious diseases EC NOS
42040	GP clinical event records	J551.00	Pneumococcal peritonitis
42040	GP clinical event records	J552000	Subhepatic abscess
42040	GP clinical event records	J552100	Subphrenic abscess
42040	GP clinical event records	J552200	Omental abscess
42040	GP clinical event records	J552300	Mesenteric abscess
42040	GP clinical event records	J552400	Peritoneal abscess
42040	GP clinical event records	J552500	Subperitoneal abscess
42040	GP clinical event records	J552600	Retroperitoneal abscess
42040	GP clinical event records	J552700	Pre-ileal abscess
42040	GP clinical event records	J552800	Pericolic abscess
42040	GP clinical event records	J552900	Pericaecal abscess
42040	GP clinical event records	J552A00	Retrocaecal abscess
42040	GP clinical event records	J552B00	Male pelvic abscess
42040	GP clinical event records	J552.00	Other suppurative peritonitis
42040	GP clinical event records	J552.11	Abscess of suppurative peritonitis
42040	GP clinical event records	J552z00	Other suppurative peritonitis NOS
42040	GP clinical event records	J553.00	Acute peritonitis
42040	GP clinical event records	J554.00	Spontaneous bacterial peritonitis
42040	GP clinical event records	J555.00	Sclerosing peritonitis
42040	GP clinical event records	J557.00	Streptococcal peritonitis
42040	GP clinical event records	J558.00	Ventriculoperitoneal shunt-associated peritonitis
42040	GP clinical event records	J55..00	Peritonitis
42040	GP clinical event records	J55y000	Chronic proliferative peritonitis
42040	GP clinical event records	J55y100	Peritoneal fat necrosis
42040	GP clinical event records	J55y300	Peritonitis due to bile
42040	GP clinical event records	J55y400	Peritonitis due to urine
42040	GP clinical event records	J55y500	Faecal peritonitis
42040	GP clinical event records	J55y.00	Other specified peritonitis
42040	GP clinical event records	J55yz00	Other specified peritonitis NOS
42040	GP clinical event records	J55z.00	Peritonitis NOS
42040	GP clinical event records	J574A00	Rupture of rectum
42040	GP clinical event records	J57yB00	Perforation of intestine
42040	GP clinical event records	J654.00	Perforation of gallbladder
42040	GP clinical event records	J654z00	Perforation of gallbladder NOS
42040	GP clinical event records	J663.00	Perforation of bile duct
42040	GP clinical event records	Jyu6000	[X]Other peritonitis
42040	GP clinical event records	XSCm1	Acute peritonitis
42040	GP clinical event records	XE0ay	Other suppurative peritonitis
42040	GP clinical event records	X309n	Sclerosing peritonitis
42040	GP clinical event records	X301n	Perforation of stomach
42040	GP clinical event records	X309d	Faecal peritonitis
42040	GP clinical event records	Xa0WI	Ventriculoperitoneal shunt-associated peritonitis
42040	GP clinical event records	XaYaL	Acute appendicitis with generalised peritonitis
42040	GP clinical event records	XaZSu	Streptococcal peritonitis
42040	GP clinical event records	XaYaN	Acute appendicitis with localised peritonitis
42040	GP clinical event records	X309e	Spontaneous bacterial peritonitis
42040	GP clinical event records	XE0aV	Acute appendicitis with appendix abscess