Metadata
| Name | Female pelvic inflammatory disease (PID) |
| Category | Infections |
| Sex | |
| Adult | Yes |
| UUID | 30159127-f77d-460c-9a41-2a117f868719 |
| Definition | An acute or chronic inflammation in the pelvic cavity. |
Ontologies
| Disease Ontology (DOID) | DOID_1003 |
| GWAS Catalogue | EFO_1001388 |
| MeSH | D000292 |
| SNOMED-CT | 198130006 |
| FinnGen | N14_FEMALEGENINF |
Key Summary Statistics
Cases from any source
| Total | 6724 |
| Female (%) | 6724 (100%) |
| Male (%) | 0 (0%) |
Year first recorded
Cases linked in all UK Biobank sources
Cross-source concordance
Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.
Incidence & prevalence
Baseline prevalence stratified by sex
| Female | 137.44 (129.61,145.28) |
| Male | 0.0 (0.0,0.0) |
Incidence stratified by sex
| Female | 7.5 (6.78,8.21) |
| Male | 0.0 (0.0,0.0) |
Incidence stratified by age
| Ages 40-44 | 7.85 (6.1,9.61) |
| Ages 45-49 | 5.49 (4.23,6.75) |
| Ages 50-54 | 4.1 (3.1,5.11) |
| Ages 55-59 | 2.51 (1.8,3.22) |
| Ages 60-64 | 3.32 (2.62,4.02) |
| Ages 65-69 | 3.63 (2.79,4.47) |
Period prevalence
Methods
Comparison with general population
Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)
| Population | Ages 40-49 | Ages 50-59 | Ages 60-69 |
| UK Biobank | 164 (153,177) | 106 (99,114) | 63 (58,68) |
| CALIBER | 386 (379,393) | 248 (241,254) | 136 (131,141) |
Stratified by age and Townsend deprivation status
| Deprivation status | Ages 40-49 | Ages 50-59 | Ages 60-69 |
| Least deprived | 143(118,172) | 102(86,119) | 66(55,78) |
| Low | 134(110,162) | 98(83,115) | 64(54,76) |
| Medium | 160(134,189) | 102(87,119) | 55(45,66) |
| High | 171(146,199) | 101(86,118) | 68(57,81) |
| Most deprived | 199(174,228) | 131(113,151) | 63(52,77) |
Stratified by age and country
| Country | Ages 40-49 | Ages 50-59 | Ages 60-69 |
| England | 172(159,186) | 111(102,120) | 66(60,71) |
| Scotland | 99(75,128) | 50(37,65) | 25(17,35) |
| Wales | 193(149,247) | 158(128,194) | 102(80,128) |
Risk factors analysis
‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.
Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method
N=153969, Events=129
| Factor | Level | Hazard Ratio | P value |
| BMI | overweight | 1.18 (0.74, 1.86) | 0.489 |
| BMI | obese | 1.91 (1.2, 3.06) | 0.00685 |
| BMI | underweight | 0 (0, Inf) | 0.995 |
| smoking | previous | 1.29 (0.88, 1.87) | 0.189 |
| smoking | current | 1.41 (0.81, 2.45) | 0.23 |
| hypertension | yes | 1.93 (1.34, 2.77) | 0.000403 |
Definition
| UK Biobank field id | Description | Code | Value |
|---|---|---|---|
| 20002 | Non-cancer illness code, self-reported | 1557 | pelvic inflammatory disease/ pid |
| 41202 | Diagnoses - main ICD10 | N70 | Salpingitis and oophoritis |
| 41202 | Diagnoses - main ICD10 | N71 | Inflammatory disease of uterus, except cervix |
| 41202 | Diagnoses - main ICD10 | N72 | Inflammatory disease of cervix uteri |
| 41202 | Diagnoses - main ICD10 | N73 | Other female pelvic inflammatory diseases |
| 41202 | Diagnoses - main ICD10 | N74 | Female pelvic inflammatory disorders in diseases classified elsewhere |
| 41204 | Diagnoses - secondary ICD10 | N70 | Salpingitis and oophoritis |
| 41204 | Diagnoses - secondary ICD10 | N71 | Inflammatory disease of uterus, except cervix |
| 41204 | Diagnoses - secondary ICD10 | N72 | Inflammatory disease of cervix uteri |
| 41204 | Diagnoses - secondary ICD10 | N73 | Other female pelvic inflammatory diseases |
| 41204 | Diagnoses - secondary ICD10 | N74 | Female pelvic inflammatory disorders in diseases classified elsewhere |
| 40001 | Underlying (primary) cause of death: ICD10 | N70 | Salpingitis and oophoritis |
| 40001 | Underlying (primary) cause of death: ICD10 | N71 | Inflammatory disease of uterus, except cervix |
| 40001 | Underlying (primary) cause of death: ICD10 | N72 | Inflammatory disease of cervix uteri |
| 40001 | Underlying (primary) cause of death: ICD10 | N73 | Other female pelvic inflammatory diseases |
| 40001 | Underlying (primary) cause of death: ICD10 | N74 | Female pelvic inflammatory disorders in diseases classified elsewhere |
| 40002 | Contributory (secondary) causes of death: ICD10 | N70 | Salpingitis and oophoritis |
| 40002 | Contributory (secondary) causes of death: ICD10 | N71 | Inflammatory disease of uterus, except cervix |
| 40002 | Contributory (secondary) causes of death: ICD10 | N72 | Inflammatory disease of cervix uteri |
| 40002 | Contributory (secondary) causes of death: ICD10 | N73 | Other female pelvic inflammatory diseases |
| 40002 | Contributory (secondary) causes of death: ICD10 | N74 | Female pelvic inflammatory disorders in diseases classified elsewhere |