| Name |
Pleural plaque (pleural_plaque) |
| Category |
Respiratory |
| Sex |
|
| Adult |
Yes |
| UUID |
084e130f-49f9-45ce-8c98-56c113c85050 |
| Definition |
Areas of scarring or calcification on the pleura caused by exposure to asbestos. |
Ontologies
Key Summary Statistics
Cases from any source
| Total |
2454 |
| Female (%) |
257 (10%) |
| Male (%) |
2197 (90%) |
Year first recorded
Cases linked in all UK Biobank sources
Cross-source concordance
Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.
Incidence & prevalence
Baseline prevalence stratified by sex
| Female |
0.47 (0.01,0.93) |
| Male |
13.58 (10.88,16.28) |
Incidence stratified by sex
| Female |
0.54 (0.35,0.74) |
| Male |
6.14 (5.43,6.84) |
Incidence stratified by age
| Ages 40-44 |
0.3 (-0.04,0.64) |
| Ages 45-49 |
0.3 (0.01,0.59) |
| Ages 50-54 |
1.33 (0.76,1.9) |
| Ages 55-59 |
1.92 (1.3,2.54) |
| Ages 60-64 |
3.34 (2.64,4.05) |
| Ages 65-69 |
8.56 (7.28,9.85) |
Period prevalence
Methods
Comparison with general population
Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)
| Population |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| UK Biobank |
3 (1,5) |
9 (7,12) |
43 (39,48) |
| CALIBER |
– |
9 (8,9) |
42 (40,45) |
Stratified by age and Townsend deprivation status
| Deprivation status |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| Least deprived |
0(NaN,NaN) |
3(1,8) |
30(23,39) |
| Low |
2(0,9) |
7(3,13) |
42(33,52) |
| Medium |
1(0,6) |
14(8,23) |
38(30,49) |
| High |
4(1,11) |
7(3,14) |
48(38,60) |
| Most deprived |
5(2,12) |
16(10,25) |
60(48,73) |
Stratified by age and country
| Country |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| England |
3(1,5) |
10(7,13) |
44(39,49) |
| Scotland |
0(NaN,NaN) |
7(3,16) |
33(22,46) |
| Wales |
4(0,21) |
12(5,27) |
49(33,69) |
Risk factors analysis
‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.
Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method
N=153513, Events=116
| Factor |
Level |
Hazard Ratio |
P value |
| BMI |
overweight |
1.85 (1.14, 2.99) |
0.0128 |
| BMI |
obese |
1.9 (1.12, 3.22) |
0.0174 |
| BMI |
underweight |
0 (0, Inf) |
0.993 |
| smoking |
previous |
0.82 (0.53, 1.27) |
0.367 |
| smoking |
current |
1.79 (1.09, 2.95) |
0.0215 |
| hypertension |
yes |
1.55 (1.01, 2.37) |
0.0432 |
Definition
| UK Biobank field id |
Description |
Code |
Value |
| 20002 |
Non-cancer illness code, self-reported |
1595 |
pleural plaques (not known asbestosis) |
| 41202 |
Diagnoses - main ICD10 |
J92.0 |
Pleural plaque with presence of asbestos |
| 41202 |
Diagnoses - main ICD10 |
J92.9 |
Pleural plaque without asbestos |
| 41204 |
Diagnoses - secondary ICD10 |
J92.0 |
Pleural plaque with presence of asbestos |
| 41204 |
Diagnoses - secondary ICD10 |
J92.9 |
Pleural plaque without asbestos |
| 40001 |
Underlying (primary) cause of death: ICD10 |
J92.0 |
Pleural plaque with presence of asbestos |
| 40001 |
Underlying (primary) cause of death: ICD10 |
J92.9 |
Pleural plaque without asbestos |
| 40002 |
Contributory (secondary) causes of death: ICD10 |
J92.0 |
Pleural plaque with presence of asbestos |
| 40002 |
Contributory (secondary) causes of death: ICD10 |
J92.9 |
Pleural plaque without asbestos |
| 42040 |
GP clinical event records |
H410.00 |
Pleural plaque disease due to asbestosis |
| 42040 |
GP clinical event records |
H410.11 |
Asbestos-induced pleural plaque |
| 42040 |
GP clinical event records |
H510100 |
Thickening of pleura |
| 42040 |
GP clinical event records |
H510C00 |
Pleural plaque |
| 42040 |
GP clinical event records |
X101T |
Pleural plaque |