| Name |
Postmenopausal bleeding (PMB) |
| Category |
Genitourinary |
| Sex |
|
| Adult |
Yes |
| UUID |
214d5258-b5fb-4b64-b053-fc4ba3059fc3 |
| Definition |
An episode of bleeding in a woman at least 12 months after her last period. |
Ontologies
Key Summary Statistics
Cases from any source
| Total |
19634 |
| Female (%) |
19634 (100%) |
| Male (%) |
0 (0%) |
Year first recorded
Cases linked in all UK Biobank sources
Cross-source concordance
Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.
Incidence & prevalence
Baseline prevalence stratified by sex
| Female |
628.17 (611.84,644.5) |
| Male |
0.0 (0.0,0.0) |
Incidence stratified by sex
| Female |
40.88 (39.15,42.61) |
| Male |
0.0 (0.0,0.0) |
Incidence stratified by age
| Ages 40-44 |
6.45 (4.87,8.03) |
| Ages 45-49 |
24.44 (21.79,27.09) |
| Ages 50-54 |
42.11 (38.85,45.36) |
| Ages 55-59 |
24.82 (22.53,27.11) |
| Ages 60-64 |
16.57 (14.96,18.18) |
| Ages 65-69 |
13.65 (11.98,15.32) |
Period prevalence
Methods
Comparison with general population
Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)
| Population |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| UK Biobank |
93 (84,102) |
430 (416,445) |
591 (576,607) |
| CALIBER |
127 (123,131) |
833 (821,845) |
1170 (1155, |
Stratified by age and Townsend deprivation status
| Deprivation status |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| Least deprived |
104(83,129) |
426(393,460) |
584(551,618) |
| Low |
84(65,107) |
432(399,466) |
591(559,625) |
| Medium |
73(56,94) |
418(386,451) |
611(578,646) |
| High |
86(69,106) |
434(402,468) |
579(545,615) |
| Most deprived |
113(94,135) |
442(409,477) |
591(555,629) |
Stratified by age and country
| Country |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| England |
92(82,102) |
443(426,460) |
593(576,610) |
| Scotland |
66(47,90) |
254(224,287) |
450(413,489) |
| Wales |
151(112,199) |
598(538,664) |
809(746,877) |
Risk factors analysis
‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.
Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method
N=153508, Events=407
| Factor |
Level |
Hazard Ratio |
P value |
| BMI |
overweight |
0.96 (0.75, 1.22) |
0.716 |
| BMI |
obese |
1.36 (1.06, 1.76) |
0.0167 |
| BMI |
underweight |
0 (0, Inf) |
0.986 |
| smoking |
previous |
1.37 (1.1, 1.7) |
0.00438 |
| smoking |
current |
2.14 (1.6, 2.85) |
2.26e-07 |
| hypertension |
yes |
1.88 (1.53, 2.31) |
1.47e-09 |
Definition
| UK Biobank field id |
Description |
Code |
Value |
| 41202 |
Diagnoses - main ICD10 |
N95.0 |
Postmenopausal bleeding |
| 41204 |
Diagnoses - secondary ICD10 |
N95.0 |
Postmenopausal bleeding |
| 40001 |
Underlying (primary) cause of death: ICD10 |
N95.0 |
Postmenopausal bleeding |
| 40002 |
Contributory (secondary) causes of death: ICD10 |
N95.0 |
Postmenopausal bleeding |
| 42040 |
GP clinical event records |
1583.00 |
H/O: post-menopausal bleeding |
| 42040 |
GP clinical event records |
K59B.00 |
Postmenopausal postcoital bleeding |
| 42040 |
GP clinical event records |
K5A1.00 |
Postmenopausal bleeding |
| 42040 |
GP clinical event records |
XaKJm |
Postmenopausal postcoital bleeding |