| Name |
Pneumothorax (pneumothorax) |
| Category |
Respiratory |
| Sex |
|
| Adult |
Yes |
| UUID |
ad9e379a-e065-45ea-829b-6c4dfa042626 |
| Definition |
A pleural disease that is characterized as an abnormal collection of air in the pleural space between the lung and the chest wall. |
Ontologies
Key Summary Statistics
Cases from any source
| Total |
3708 |
| Female (%) |
1276 (34%) |
| Male (%) |
2432 (66%) |
Year first recorded
Cases linked in all UK Biobank sources
Cross-source concordance
Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.
Incidence & prevalence
Baseline prevalence stratified by sex
| Female |
26.88 (23.39,30.36) |
| Male |
78.68 (72.2,85.16) |
Incidence stratified by sex
| Female |
1.39 (1.08,1.7) |
| Male |
3.2 (2.69,3.71) |
Incidence stratified by age
| Ages 40-44 |
0.81 (0.25,1.37) |
| Ages 45-49 |
1.42 (0.78,2.05) |
| Ages 50-54 |
1.46 (0.86,2.06) |
| Ages 55-59 |
2.04 (1.4,2.68) |
| Ages 60-64 |
2.16 (1.59,2.73) |
| Ages 65-69 |
4.29 (3.38,5.2) |
Period prevalence
Methods
Comparison with general population
Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)
| Population |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| UK Biobank |
44 (38,51) |
47 (42,53) |
56 (51,61) |
| CALIBER |
49 (47,51) |
59 (56,61) |
75 (72,78) |
Stratified by age and Townsend deprivation status
| Deprivation status |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| Least deprived |
45(31,64) |
44(33,57) |
61(50,73) |
| Low |
37(24,55) |
38(28,51) |
49(39,60) |
| Medium |
34(22,51) |
48(36,62) |
48(39,60) |
| High |
48(35,65) |
44(33,57) |
59(48,72) |
| Most deprived |
53(40,70) |
62(49,77) |
63(51,77) |
Stratified by age and country
| Country |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| England |
45(38,53) |
47(41,53) |
54(49,60) |
| Scotland |
52(34,78) |
63(47,83) |
81(65,101) |
| Wales |
29(13,56) |
23(12,41) |
33(21,50) |
Risk factors analysis
‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.
Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method
N=153513, Events=116
| Factor |
Level |
Hazard Ratio |
P value |
| BMI |
overweight |
1.85 (1.14, 2.99) |
0.0128 |
| BMI |
obese |
1.9 (1.12, 3.22) |
0.0174 |
| BMI |
underweight |
0 (0, Inf) |
0.993 |
| smoking |
previous |
0.82 (0.53, 1.27) |
0.367 |
| smoking |
current |
1.79 (1.09, 2.95) |
0.0215 |
| hypertension |
yes |
1.55 (1.01, 2.37) |
0.0432 |
Definition
| UK Biobank field id |
Description |
Code |
Value |
| 20002 |
Non-cancer illness code, self-reported |
1126 |
spontaneous pneumothorax/recurrent pneumothorax |
| 20002 |
Non-cancer illness code, self-reported |
1497 |
pneumothorax |
| 41202 |
Diagnoses - main ICD10 |
J93 |
Pneumothorax |
| 41204 |
Diagnoses - secondary ICD10 |
J93 |
Pneumothorax |
| 40001 |
Underlying (primary) cause of death: ICD10 |
J93 |
Pneumothorax |
| 40002 |
Contributory (secondary) causes of death: ICD10 |
J93 |
Pneumothorax |
| 42040 |
GP clinical event records |
14B5.00 |
H/O: pneumothorax |
| 42040 |
GP clinical event records |
H520.00 |
Spontaneous tension pneumothorax |
| 42040 |
GP clinical event records |
H52..00 |
Pneumothorax |
| 42040 |
GP clinical event records |
H52y000 |
Acute pneumothorax NOS |
| 42040 |
GP clinical event records |
H52y100 |
Chronic pneumothorax |
| 42040 |
GP clinical event records |
H52y.00 |
Other spontaneous pneumothorax |
| 42040 |
GP clinical event records |
H52yz00 |
Other spontaneous pneumothorax NOS |
| 42040 |
GP clinical event records |
H52yz11 |
Spontaneous pneumothorax NOS |
| 42040 |
GP clinical event records |
H52z.00 |
Pneumothorax NOS |
| 42040 |
GP clinical event records |
Hyu7100 |
[X]Other spontaneous pneumothorax |
| 42040 |
GP clinical event records |
Hyu7200 |
[X]Other pneumothorax |
| 42040 |
GP clinical event records |
XE0YZ |
Other spontaneous pneumothorax NOS |