| Name |
Portal hypertension (portal_htn) |
| Category |
Digestive |
| Sex |
|
| Adult |
Yes |
| UUID |
70e1671f-b7c1-4515-89d6-d3e85f3acff1 |
| Definition |
Increased blood pressure in the portal venous system. |
Ontologies
Key Summary Statistics
Cases from any source
| Total |
1393 |
| Female (%) |
455 (33%) |
| Male (%) |
938 (67%) |
Year first recorded
Cases linked in all UK Biobank sources
Cross-source concordance
Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.
Incidence & prevalence
Baseline prevalence stratified by sex
| Female |
2.12 (1.14,3.1) |
| Male |
5.6 (3.86,7.33) |
Incidence stratified by sex
| Female |
0.84 (0.6,1.08) |
| Male |
2.1 (1.69,2.52) |
Incidence stratified by age
| Ages 40-44 |
0.6 (0.12,1.09) |
| Ages 45-49 |
0.74 (0.28,1.2) |
| Ages 50-54 |
1.27 (0.71,1.82) |
| Ages 55-59 |
1.71 (1.13,2.3) |
| Ages 60-64 |
1.57 (1.09,2.06) |
| Ages 65-69 |
1.91 (1.3,2.51) |
Period prevalence
Methods
Comparison with general population
Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)
| Population |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| UK Biobank |
6 (4,9) |
13 (11,17) |
16 (13,19) |
| CALIBER |
15 (14,16) |
25 (23,26) |
26 (24,27) |
Stratified by age and Townsend deprivation status
| Deprivation status |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| Least deprived |
1(0,7) |
6(3,12) |
9(5,15) |
| Low |
3(0,10) |
5(2,10) |
11(7,17) |
| Medium |
3(0,10) |
11(6,18) |
17(12,24) |
| High |
8(3,16) |
16(10,25) |
20(14,28) |
| Most deprived |
11(5,20) |
29(21,40) |
24(17,34) |
Stratified by age and country
| Country |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| England |
5(3,8) |
13(10,17) |
15(12,18) |
| Scotland |
5(1,17) |
19(11,31) |
22(14,33) |
| Wales |
14(4,36) |
10(3,24) |
18(9,31) |
Risk factors analysis
‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.
Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method
N=153646, Events=402
| Factor |
Level |
Hazard Ratio |
P value |
| BMI |
overweight |
1.07 (0.82, 1.39) |
0.637 |
| BMI |
obese |
2.13 (1.65, 2.77) |
1.06e-08 |
| BMI |
underweight |
0 (0, Inf) |
0.986 |
| smoking |
previous |
1.48 (1.19, 1.85) |
0.000498 |
| smoking |
current |
2.47 (1.87, 3.26) |
1.43e-10 |
| hypertension |
yes |
2.21 (1.8, 2.72) |
5.76e-14 |
Definition
| UK Biobank field id |
Description |
Code |
Value |
| 41202 |
Diagnoses - main ICD10 |
K76.6 |
Portal hypertension |
| 41204 |
Diagnoses - secondary ICD10 |
K76.6 |
Portal hypertension |
| 40001 |
Underlying (primary) cause of death: ICD10 |
K76.6 |
Portal hypertension |
| 40002 |
Contributory (secondary) causes of death: ICD10 |
K76.6 |
Portal hypertension |
| 42040 |
GP clinical event records |
J623.00 |
Portal hypertension |