Primary Malignancy of biliary tract

Metadata

Name	Primary Malignancy of biliary tract (pri_biliary)
Category	Cancers
Sex
Adult	Yes
UUID	bd9780b7-ba5a-455b-803c-c4b607ddbb4c
Definition	A neoplasm that involves the biliary tract.

Ontologies

Disease Ontology (DOID)	DOID_4607
GWAS Catalogue	MONDO_0003060
MeSH	D001661
SNOMED-CT	126853008
FinnGen	C3_BILIARY_TRACT

Key Summary Statistics

Cases from any source

Total	832
Female (%)	404 (49%)
Male (%)	428 (51%)

Year first recorded

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Incidence & prevalence

Baseline prevalence stratified by sex

Female	1.18 (0.45,1.91)
Male	1.96 (0.93,2.99)

Incidence stratified by sex

Female	0.84 (0.6,1.08)
Male	1.16 (0.85,1.46)

Incidence stratified by age

Ages 40-44	0.0 (0.0,0.0)
Ages 45-49	0.15 (-0.06,0.35)
Ages 50-54	0.57 (0.2,0.94)
Ages 55-59	0.94 (0.5,1.37)
Ages 60-64	1.38 (0.93,1.83)
Ages 65-69	1.91 (1.3,2.51)

Period prevalence

Methods

Comparison with general population

Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)

Population	Ages 40-49	Ages 50-59	Ages 60-69
UK Biobank	1 (0,3)	4 (3,6)	10 (8,13)
CALIBER	–	4 (3,5)	9 (8,10)

Stratified by age and Townsend deprivation status

Deprivation status	Ages 40-49	Ages 50-59	Ages 60-69
Least deprived	0(NaN,NaN)	6(2,11)	9(5,14)
Low	2(0,9)	2(0,7)	12(8,18)
Medium	1(0,8)	5(2,10)	9(5,14)
High	2(0,8)	4(1,9)	10(6,16)
Most deprived	1(0,5)	4(2,9)	12(7,19)

Stratified by age and country

Country	Ages 40-49	Ages 50-59	Ages 60-69
England	2(0,4)	4(2,6)	10(8,12)
Scotland	0(NaN,NaN)	4(1,10)	14(8,23)
Wales	0(NaN,NaN)	6(1,18)	9(3,19)

Risk factors analysis

‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.

Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method

N=153561, Events=310

Factor	Level	Hazard Ratio	P value
BMI	overweight	0.89 (0.68, 1.17)	0.406
BMI	obese	1.13 (0.84, 1.51)	0.416
BMI	underweight	0 (0, Inf)	0.987
smoking	previous	0.95 (0.75, 1.22)	0.699
smoking	current	1.05 (0.72, 1.55)	0.789
hypertension	yes	1.12 (0.87, 1.45)	0.386

Definition

UK Biobank field id	Description	Code	Value
20001	Cancer code, self-reported	1025	gallbladder/bile duct cancer
41202	Diagnoses - main ICD10	C22.1	Malignant neoplasm: Intrahepatic bile duct carcinoma
41202	Diagnoses - main ICD10	C24	Malignant neoplasm of other and unspecified parts of biliary tract
41204	Diagnoses - secondary ICD10	C22.1	Malignant neoplasm: Intrahepatic bile duct carcinoma
41204	Diagnoses - secondary ICD10	C24	Malignant neoplasm of other and unspecified parts of biliary tract
40001	Underlying (primary) cause of death: ICD10	C22.1	Malignant neoplasm: Intrahepatic bile duct carcinoma
40001	Underlying (primary) cause of death: ICD10	C24	Malignant neoplasm of other and unspecified parts of biliary tract
40002	Contributory (secondary) causes of death: ICD10	C22.1	Malignant neoplasm: Intrahepatic bile duct carcinoma
40002	Contributory (secondary) causes of death: ICD10	C24	Malignant neoplasm of other and unspecified parts of biliary tract
42040	GP clinical event records	B151000	Malignant neoplasm of interlobular bile ducts
42040	GP clinical event records	B151200	Malignant neoplasm of intrahepatic biliary passages
42040	GP clinical event records	B151400	Malignant neoplasm of intrahepatic gall duct
42040	GP clinical event records	B151.00	Malignant neoplasm of intrahepatic bile ducts
42040	GP clinical event records	B151z00	Malignant neoplasm of intrahepatic bile ducts NOS
42040	GP clinical event records	B161000	Malignant neoplasm of cystic duct
42040	GP clinical event records	B161100	Malignant neoplasm of hepatic duct
42040	GP clinical event records	B161200	Malignant neoplasm of common bile duct
42040	GP clinical event records	B161211	Carcinoma common bile duct
42040	GP clinical event records	B161300	Malignant neoplasm of sphincter of Oddi
42040	GP clinical event records	B161.00	Malignant neoplasm of extrahepatic bile ducts
42040	GP clinical event records	B161z00	Malignant neoplasm of extrahepatic bile ducts NOS
42040	GP clinical event records	B162.00	Malignant neoplasm of ampulla of Vater
42040	GP clinical event records	B163.00	Malignant neoplasm, overlapping lesion of biliary tract
42040	GP clinical event records	BB5D100	[M]Cholangiocarcinoma
42040	GP clinical event records	BB5D111	[M]Bile duct carcinoma
42040	GP clinical event records	BB5D300	[M]Bile duct cystadenocarcinoma
42040	GP clinical event records	BB5D700	[M]Combined hepatocellular carcinoma and cholangiocarcinoma
42040	GP clinical event records	BB5D711	[M]Hepatocholangiocarcinoma
42040	GP clinical event records	XE2vN	Malignant neoplasm of common bile duct
40006	Type of cancer: ICD10	C22.1	Malignant neoplasm: Intrahepatic bile duct carcinoma
40006	Type of cancer: ICD10	C24	Malignant neoplasm of other and unspecified parts of biliary tract