Metadata
| Name | Primary Malignancy of Bladder (pri_bladder) |
| Category | Cancers |
| Sex | |
| Adult | Yes |
| UUID | 73b5a329-4748-4325-99fb-2e86ea8a985c |
| Definition | Malignant neoplasm of bladder. |
Ontologies
| Disease Ontology (DOID) | DOID_11054 |
| GWAS Catalogue | EFO_0000292 |
| MeSH | D001749 |
| SNOMED-CT | 399326009 |
| FinnGen | C3_BLADDER |
Key Summary Statistics
Cases from any source
| Total | 4584 |
| Female (%) | 1161 (25%) |
| Male (%) | 3423 (75%) |
Year first recorded
Cases linked in all UK Biobank sources
Cross-source concordance
Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.
Incidence & prevalence
Baseline prevalence stratified by sex
| Female | 16.27 (13.56,18.98) |
| Male | 48.44 (43.35,53.53) |
Incidence stratified by sex
| Female | 2.13 (1.75,2.51) |
| Male | 7.94 (7.14,8.75) |
Incidence stratified by age
| Ages 40-44 | 1.01 (0.38,1.63) |
| Ages 45-49 | 0.82 (0.33,1.3) |
| Ages 50-54 | 1.84 (1.17,2.51) |
| Ages 55-59 | 4.01 (3.12,4.91) |
| Ages 60-64 | 5.87 (4.93,6.8) |
| Ages 65-69 | 11.0 (9.53,12.46) |
Period prevalence
Methods
Comparison with general population
Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)
| Population | Ages 40-49 | Ages 50-59 | Ages 60-69 |
| UK Biobank | 10 (7,14) | 30 (26,35) | 88 (81,94) |
| CALIBER | 8 (7,8) | 25 (23,26) | 83 (80,86) |
Stratified by age and Townsend deprivation status
| Deprivation status | Ages 40-49 | Ages 50-59 | Ages 60-69 |
| Least deprived | 4(1,13) | 29(20,40) | 83(70,97) |
| Low | 8(3,17) | 30(20,41) | 92(79,107) |
| Medium | 9(4,19) | 22(15,32) | 94(80,109) |
| High | 13(6,23) | 35(26,47) | 80(67,95) |
| Most deprived | 15(8,24) | 35(25,47) | 89(74,105) |
Stratified by age and country
| Country | Ages 40-49 | Ages 50-59 | Ages 60-69 |
| England | 10(7,14) | 30(25,35) | 91(84,98) |
| Scotland | 10(3,24) | 29(18,43) | 67(52,85) |
| Wales | 10(2,31) | 33(19,53) | 83(63,108) |
Risk factors analysis
‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.
Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method
N=153561, Events=310
| Factor | Level | Hazard Ratio | P value |
| BMI | overweight | 0.89 (0.68, 1.17) | 0.406 |
| BMI | obese | 1.13 (0.84, 1.51) | 0.416 |
| BMI | underweight | 0 (0, Inf) | 0.987 |
| smoking | previous | 0.95 (0.75, 1.22) | 0.699 |
| smoking | current | 1.05 (0.72, 1.55) | 0.789 |
| hypertension | yes | 1.12 (0.87, 1.45) | 0.386 |
Definition
| UK Biobank field id | Description | Code | Value |
|---|---|---|---|
| 20001 | Cancer code, self-reported | 1035 | bladder cancer |
| 41202 | Diagnoses - main ICD10 | C67 | Malignant neoplasm of bladder |
| 41204 | Diagnoses - secondary ICD10 | C67 | Malignant neoplasm of bladder |
| 40001 | Underlying (primary) cause of death: ICD10 | C67 | Malignant neoplasm of bladder |
| 40002 | Contributory (secondary) causes of death: ICD10 | C67 | Malignant neoplasm of bladder |
| 42040 | GP clinical event records | B490.00 | Malignant neoplasm of trigone of urinary bladder |
| 42040 | GP clinical event records | B491.00 | Malignant neoplasm of dome of urinary bladder |
| 42040 | GP clinical event records | B492.00 | Malignant neoplasm of lateral wall of urinary bladder |
| 42040 | GP clinical event records | B493.00 | Malignant neoplasm of anterior wall of urinary bladder |
| 42040 | GP clinical event records | B494.00 | Malignant neoplasm of posterior wall of urinary bladder |
| 42040 | GP clinical event records | B495.00 | Malignant neoplasm of bladder neck |
| 42040 | GP clinical event records | B496.00 | Malignant neoplasm of ureteric orifice |
| 42040 | GP clinical event records | B497.00 | Malignant neoplasm of urachus |
| 42040 | GP clinical event records | B498.00 | Local recurrence of malignant tumour of urinary bladder |
| 42040 | GP clinical event records | B49..00 | Malignant neoplasm of urinary bladder |
| 42040 | GP clinical event records | B49y000 | Malignant neoplasm, overlapping lesion of bladder |
| 42040 | GP clinical event records | B49y.00 | Malignant neoplasm of other site of urinary bladder |
| 42040 | GP clinical event records | B49z.00 | Malignant neoplasm of urinary bladder NOS |
| 42040 | GP clinical event records | ZV10511 | [V]Personal history of malignant neoplasm of bladder |
| 42040 | GP clinical event records | XaFrL | Local recurrence of malignant tumour of urinary bladder |
| 40006 | Type of cancer: ICD10 | C67 | Malignant neoplasm of bladder |