Metadata

Name Primary Malignancy of Bone and articular cartilage (pri_bone)
Category Cancers
Sex
Adult Yes
UUID 56ee92ef-b6a6-4954-bf3d-1da0c27e16e7
Definition A benign, intermediate, or malignant neoplasm involving the bone or articular cartilage.

Ontologies

Disease Ontology (DOID) DOID_184
GWAS Catalogue EFO_0003820
MeSH D001859
SNOMED-CT 428281000
FinnGen C3_BONE_CARTILAGE_LIMBS

Key Summary Statistics

Cases from any source

Total 442
Female (%) 200 (45%)
Male (%) 242 (55%)

Year first recorded

pri_bone year of first event

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Cross-sourced pri_bone cases

Incidence & prevalence

Sex and age-stratified incidence and prevalence of pri_bone

Baseline prevalence stratified by sex

Female 4.72 (3.25,6.18)
Male 5.32 (3.63,7.01)

Incidence stratified by sex

Female 0.19 (0.08,0.31)
Male 0.44 (0.25,0.63)

Incidence stratified by age

Ages 40-44 0.1 (-0.1,0.3)
Ages 45-49 0.07 (-0.07,0.22)
Ages 50-54 0.13 (-0.05,0.3)
Ages 55-59 0.47 (0.16,0.77)
Ages 60-64 0.5 (0.23,0.77)
Ages 65-69 0.3 (0.06,0.54)

Period prevalence

Methods

Comparison with general population

Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)

CALIBER and UKB pri_bone prevalence comparison for multiple age groups

Population Ages 40-49 Ages 50-59 Ages 60-69
UK Biobank 3 (2,5) 5 (3,7) 6 (5,8)
CALIBER 3 (3,4) 4 (3,4) 6 (5,7)

Stratified by age and Townsend deprivation status

Deprivation status Ages 40-49 Ages 50-59 Ages 60-69
Least deprived 2(0,9) 7(3,13) 4(2,8)
Low 0(NaN,NaN) 5(2,11) 5(2,10)
Medium 2(0,8) 8(4,15) 5(3,10)
High 4(1,11) 2(0,6) 10(6,15)
Most deprived 5(2,12) 2(0,6) 7(4,13)

Stratified by age and country

Country Ages 40-49 Ages 50-59 Ages 60-69
England 2(1,5) 4(2,6) 6(4,8)
Scotland 6(1,19) 7(2,15) 5(1,11)
Wales 3(0,17) 10(3,24) 10(4,20)

Definition

UK Biobank field id Description Code Value
20001 Cancer code, self-reported 1063 primary bone cancer
41202 Diagnoses - main ICD10 C40 Malignant neoplasm of bone and articular cartilage of limbs
41202 Diagnoses - main ICD10 C41 Malignant neoplasm of bone and articular cartilage of other and unspecified sites
41204 Diagnoses - secondary ICD10 C40 Malignant neoplasm of bone and articular cartilage of limbs
41204 Diagnoses - secondary ICD10 C41 Malignant neoplasm of bone and articular cartilage of other and unspecified sites
40001 Underlying (primary) cause of death: ICD10 C40 Malignant neoplasm of bone and articular cartilage of limbs
40001 Underlying (primary) cause of death: ICD10 C41 Malignant neoplasm of bone and articular cartilage of other and unspecified sites
40002 Contributory (secondary) causes of death: ICD10 C40 Malignant neoplasm of bone and articular cartilage of limbs
40002 Contributory (secondary) causes of death: ICD10 C41 Malignant neoplasm of bone and articular cartilage of other and unspecified sites
42040 GP clinical event records B300000 Malignant neoplasm of ethmoid bone
42040 GP clinical event records B300100 Malignant neoplasm of frontal bone
42040 GP clinical event records B300200 Malignant neoplasm of malar bone
42040 GP clinical event records B300300 Malignant neoplasm of nasal bone
42040 GP clinical event records B300400 Malignant neoplasm of occipital bone
42040 GP clinical event records B300500 Malignant neoplasm of orbital bone
42040 GP clinical event records B300600 Malignant neoplasm of parietal bone
42040 GP clinical event records B300700 Malignant neoplasm of sphenoid bone
42040 GP clinical event records B300800 Malignant neoplasm of temporal bone
42040 GP clinical event records B300900 Malignant neoplasm of zygomatic bone
42040 GP clinical event records B300A00 Malignant neoplasm of maxilla
42040 GP clinical event records B300.00 Malignant neoplasm of bones of skull and face
42040 GP clinical event records B300B00 Malignant neoplasm of turbinate
42040 GP clinical event records B300C00 Malignant neoplasm of vomer
42040 GP clinical event records B300z00 Malignant neoplasm of bones of skull and face NOS
42040 GP clinical event records B301.00 Malignant neoplasm of mandible
42040 GP clinical event records B302000 Malignant neoplasm of cervical vertebra
42040 GP clinical event records B302100 Malignant neoplasm of thoracic vertebra
42040 GP clinical event records B302200 Malignant neoplasm of lumbar vertebra
42040 GP clinical event records B302.00 Malignant neoplasm of vertebral column
42040 GP clinical event records B302z00 Malignant neoplasm of vertebral column NOS
42040 GP clinical event records B303000 Malignant neoplasm of rib
42040 GP clinical event records B303100 Malignant neoplasm of sternum
42040 GP clinical event records B303200 Malignant neoplasm of clavicle
42040 GP clinical event records B303300 Malignant neoplasm of costal cartilage
42040 GP clinical event records B303400 Malignant neoplasm of costo-vertebral joint
42040 GP clinical event records B303500 Malignant neoplasm of xiphoid process
42040 GP clinical event records B303.00 Malignant neoplasm of ribs, sternum and clavicle
42040 GP clinical event records B303z00 Malignant neoplasm of rib, sternum and clavicle NOS
42040 GP clinical event records B304000 Malignant neoplasm of scapula
42040 GP clinical event records B304100 Malignant neoplasm of acromion
42040 GP clinical event records B304200 Malignant neoplasm of humerus
42040 GP clinical event records B304300 Malignant neoplasm of radius
42040 GP clinical event records B304400 Malignant neoplasm of ulna
42040 GP clinical event records B304.00 Malignant neoplasm of scapula and long bones of upper arm
42040 GP clinical event records B304z00 Malig neop of scapula and long bones of upper arm NOS
42040 GP clinical event records B305000 Malignant neoplasm of carpal bone - scaphoid
42040 GP clinical event records B305100 Malignant neoplasm of carpal bone - lunate
42040 GP clinical event records B305A00 Malignant neoplasm of third metacarpal bone
42040 GP clinical event records B305.00 Malignant neoplasm of hand bones
42040 GP clinical event records B305.11 Malignant neoplasm of carpal bones
42040 GP clinical event records B305.12 Malignant neoplasm of metacarpal bones
42040 GP clinical event records B305C00 Malignant neoplasm of fifth metacarpal bone
42040 GP clinical event records B305D00 Malignant neoplasm of phalanges of hand
42040 GP clinical event records B305z00 Malignant neoplasm of hand bones NOS
42040 GP clinical event records B306000 Malignant neoplasm of ilium
42040 GP clinical event records B306100 Malignant neoplasm of ischium
42040 GP clinical event records B306200 Malignant neoplasm of pubis
42040 GP clinical event records B306300 Malignant neoplasm of sacral vertebra
42040 GP clinical event records B306400 Malignant neoplasm of coccygeal vertebra
42040 GP clinical event records B306500 Malignant sacral teratoma
42040 GP clinical event records B306.00 Malignant neoplasm of pelvic bones, sacrum and coccyx
42040 GP clinical event records B306z00 Malignant neoplasm of pelvis, sacrum or coccyx NOS
42040 GP clinical event records B307000 Malignant neoplasm of femur
42040 GP clinical event records B307100 Malignant neoplasm of fibula
42040 GP clinical event records B307200 Malignant neoplasm of tibia
42040 GP clinical event records B307.00 Malignant neoplasm of long bones of leg
42040 GP clinical event records B307z00 Malignant neoplasm of long bones of leg NOS
42040 GP clinical event records B308100 Malignant neoplasm of talus
42040 GP clinical event records B308200 Malignant neoplasm of calcaneum
42040 GP clinical event records B308300 Malignant neoplasm of medial cuneiform
42040 GP clinical event records B308800 Malignant neoplasm of first metatarsal bone
42040 GP clinical event records B308.00 Malignant neoplasm of short bones of leg
42040 GP clinical event records B308B00 Malignant neoplasm of fourth metatarsal bone
42040 GP clinical event records B308D00 Malignant neoplasm of phalanges of foot
42040 GP clinical event records B308z00 Malignant neoplasm of short bones of leg NOS
42040 GP clinical event records B30..00 Malignant neoplasm of bone and articular cartilage
42040 GP clinical event records B30W.00 Malignant neoplasm/overlap lesion/bone+articulr cartilage
42040 GP clinical event records B30X.00 Malignant neoplasm/bones+articular cartilage/limb,unspfd
42040 GP clinical event records B30z000 Osteosarcoma
42040 GP clinical event records B30z.00 Malignant neoplasm of bone and articular cartilage NOS
42040 GP clinical event records BBV1.00 [M]Osteosarcoma NOS
42040 GP clinical event records BBV1.11 [M]Osteoblastic sarcoma
42040 GP clinical event records BBV1.12 [M]Osteochondrosarcoma
42040 GP clinical event records BBV1.13 [M]Osteogenic sarcoma NOS
42040 GP clinical event records BBV2.00 [M]Chondroblastic osteosarcoma
42040 GP clinical event records BBV3.00 [M]Fibroblastic osteosarcoma
42040 GP clinical event records BBV4.00 [M]Telangiectatic osteosarcoma
42040 GP clinical event records BBV5.00 [M]Osteosarcoma in Paget’s disease of bone
42040 GP clinical event records BBV9.00 [M]Myxoid chondrosarcoma
42040 GP clinical event records BBVA.00 [M] Small cell osteosarcoma
42040 GP clinical event records BBV..11 [M]Juxtacortical osteogenic sarcoma
42040 GP clinical event records BBV..12 [M]Parosteal osteosarcoma
42040 GP clinical event records BBV..13 [M]Periosteal osteogenic sarcoma
42040 GP clinical event records BBW4.00 [M]Chondrosarcoma NOS
42040 GP clinical event records BBW4.11 [M]Fibrochondrosarcoma
42040 GP clinical event records BBW6.00 [M]Juxtacortical chondrosarcoma
42040 GP clinical event records BBW8.00 [M]Chondroblastoma, malignant
42040 GP clinical event records BBW9.00 [M]Mesenchymal chondrosarcoma
42040 GP clinical event records BBX1.00 [M]Giant cell tumour of bone, malignant
42040 GP clinical event records BBX1.11 [M]Giant cell bone sarcoma
42040 GP clinical event records BBX1.12 [M]Osteoclastoma, malignant
42040 GP clinical event records BBY0.00 [M]Ewing’s sarcoma
42040 GP clinical event records BBY0.11 [M]Endothelial bone sarcoma
42040 GP clinical event records BBY1.00 [M]Adamantinoma of long bones
42040 GP clinical event records BBY1.11 [M]Tibial adamantinoma
42040 GP clinical event records BBZ2.00 [M]Odontogenic tumour, malignant
42040 GP clinical event records BBZ2.11 [M]Intraosseous carcinoma
42040 GP clinical event records BBZC.00 [M]Ameloblastic odontosarcoma
42040 GP clinical event records BBZG.00 [M]Ameloblastoma, malignant
42040 GP clinical event records BBZG.11 [M]Adamantinoma, malignant
42040 GP clinical event records BBZN.00 [M]Ameloblastic fibrosarcoma
42040 GP clinical event records BBZN.11 [M]Odontogenic fibrosarcoma
42040 GP clinical event records Byu3100 [X]Malignant neoplasm/bones+articular cartilage/limb,unspfd
42040 GP clinical event records Byu3200 [X]Malignant neoplasm/overlap lesion/bone+articulr cartilage
42040 GP clinical event records Byu3300 [X]Malignant neoplasm/bone+articular cartilage, unspecified
42040 GP clinical event records Byu3.00 [X]Malignant neoplasm of bone and articular cartilage
42040 GP clinical event records ZV10y11 [V]Personal history of malignant neoplasm of bone
42040 GP clinical event records XE1ve Malignant neoplasm of hand bones
42040 GP clinical event records XE1wY [M]Osteomas and osteosarcomas
42040 GP clinical event records XE1wZ [M]Adamantinoma of long bones
42040 GP clinical event records XE1vf Malignant neoplasm of short bones of leg
42040 GP clinical event records XaKWz Malignant sacral teratoma
40006 Type of cancer: ICD10 C40 Malignant neoplasm of bone and articular cartilage of limbs
40006 Type of cancer: ICD10 C41 Malignant neoplasm of bone and articular cartilage of other and unspecified sites