Primary Malignancy of colorectal and anus

Metadata

Name	Primary Malignancy of colorectal and anus (pri_bowel)
Category	Cancers
Sex
Adult	Yes
UUID	76e391ad-1d01-49d1-8994-e01ec55c6093

Ontologies

GWAS Catalogue

EFO_0005842

Key Summary Statistics

Cases from any source

Total	10350
Female (%)	4662 (45%)
Male (%)	5688 (55%)

Year first recorded

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Incidence & prevalence

Baseline prevalence stratified by sex

Female	52.34 (47.48,57.19)
Male	75.18 (68.84,81.51)

Incidence stratified by sex

Female	9.26 (8.46,10.05)
Male	14.35 (13.27,15.44)

Incidence stratified by age

Ages 40-44	2.21 (1.29,3.14)
Ages 45-49	3.94 (2.88,5.0)
Ages 50-54	7.89 (6.5,9.28)
Ages 55-59	10.74 (9.27,12.21)
Ages 60-64	14.64 (13.16,16.11)
Ages 65-69	21.31 (19.27,23.36)

Period prevalence

Methods

Comparison with general population

Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)

Population	Ages 40-49	Ages 50-59	Ages 60-69
UK Biobank	27 (22,33)	88 (81,95)	179 (171,188)
CALIBER	18 (17,19)	60 (58,63)	156 (152,160)

Stratified by age and Townsend deprivation status

Deprivation status	Ages 40-49	Ages 50-59	Ages 60-69
Least deprived	30(18,45)	99(83,118)	171(153,190)
Low	32(20,48)	83(68,101)	193(174,214)
Medium	23(13,36)	85(69,102)	158(141,178)
High	26(17,39)	88(73,106)	163(144,184)
Most deprived	26(17,38)	84(69,101)	217(194,241)

Stratified by age and country

Country	Ages 40-49	Ages 50-59	Ages 60-69
England	26(21,32)	84(77,93)	174(165,184)
Scotland	37(22,58)	98(78,121)	199(173,228)
Wales	22(8,48)	103(77,135)	202(169,239)

Risk factors analysis

‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.

Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method

N=153561, Events=310

Factor	Level	Hazard Ratio	P value
BMI	overweight	0.89 (0.68, 1.17)	0.406
BMI	obese	1.13 (0.84, 1.51)	0.416
BMI	underweight	0 (0, Inf)	0.987
smoking	previous	0.95 (0.75, 1.22)	0.699
smoking	current	1.05 (0.72, 1.55)	0.789
hypertension	yes	1.12 (0.87, 1.45)	0.386

Definition

UK Biobank field id	Description	Code	Value
20001	Cancer code, self-reported	1020	large bowel cancer/colorectal cancer
20001	Cancer code, self-reported	1022	colon cancer/sigmoid cancer
20001	Cancer code, self-reported	1023	rectal cancer
41202	Diagnoses - main ICD10	C18	Malignant neoplasm of colon
41202	Diagnoses - main ICD10	C19	Malignant neoplasm of rectosigmoid junction
41202	Diagnoses - main ICD10	C20	Malignant neoplasm of rectum
41202	Diagnoses - main ICD10	C21	Malignant neoplasm of anus and anal canal
41204	Diagnoses - secondary ICD10	C18	Malignant neoplasm of colon
41204	Diagnoses - secondary ICD10	C19	Malignant neoplasm of rectosigmoid junction
41204	Diagnoses - secondary ICD10	C20	Malignant neoplasm of rectum
41204	Diagnoses - secondary ICD10	C21	Malignant neoplasm of anus and anal canal
40001	Underlying (primary) cause of death: ICD10	C18	Malignant neoplasm of colon
40001	Underlying (primary) cause of death: ICD10	C19	Malignant neoplasm of rectosigmoid junction
40001	Underlying (primary) cause of death: ICD10	C20	Malignant neoplasm of rectum
40001	Underlying (primary) cause of death: ICD10	C21	Malignant neoplasm of anus and anal canal
40002	Contributory (secondary) causes of death: ICD10	C18	Malignant neoplasm of colon
40002	Contributory (secondary) causes of death: ICD10	C19	Malignant neoplasm of rectosigmoid junction
40002	Contributory (secondary) causes of death: ICD10	C20	Malignant neoplasm of rectum
40002	Contributory (secondary) causes of death: ICD10	C21	Malignant neoplasm of anus and anal canal
42040	GP clinical event records	B130.00	Malignant neoplasm of hepatic flexure of colon
42040	GP clinical event records	B131.00	Malignant neoplasm of transverse colon
42040	GP clinical event records	B132.00	Malignant neoplasm of descending colon
42040	GP clinical event records	B133.00	Malignant neoplasm of sigmoid colon
42040	GP clinical event records	B134.00	Malignant neoplasm of caecum
42040	GP clinical event records	B134.11	Carcinoma of caecum
42040	GP clinical event records	B135.00	Malignant neoplasm of appendix
42040	GP clinical event records	B136.00	Malignant neoplasm of ascending colon
42040	GP clinical event records	B137.00	Malignant neoplasm of splenic flexure of colon
42040	GP clinical event records	B138.00	Malignant neoplasm, overlapping lesion of colon
42040	GP clinical event records	B139.00	Hereditary nonpolyposis colon cancer
42040	GP clinical event records	B13..00	Malignant neoplasm of colon
42040	GP clinical event records	B13y.00	Malignant neoplasm of other specified sites of colon
42040	GP clinical event records	B13z.00	Malignant neoplasm of colon NOS
42040	GP clinical event records	B13z.11	Colonic cancer
42040	GP clinical event records	B140.00	Malignant neoplasm of rectosigmoid junction
42040	GP clinical event records	B141.00	Malignant neoplasm of rectum
42040	GP clinical event records	B141.11	Carcinoma of rectum
42040	GP clinical event records	B141.12	Rectal carcinoma
42040	GP clinical event records	B142000	Malignant neoplasm of cloacogenic zone
42040	GP clinical event records	B142.00	Malignant neoplasm of anal canal
42040	GP clinical event records	B142.11	Anal carcinoma
42040	GP clinical event records	B143.00	Malignant neoplasm of anus unspecified
42040	GP clinical event records	B14..00	Malignant neoplasm of rectum, rectosigmoid junction and anus
42040	GP clinical event records	B14y.00	Malig neop other site rectum, rectosigmoid junction and anus
42040	GP clinical event records	B14z.00	Malignant neoplasm rectum,rectosigmoid junction and anus NOS
42040	GP clinical event records	B1z0.11	Cancer of bowel
42040	GP clinical event records	ZV10011	[V]Personal history of malignant neoplasm of anus
42040	GP clinical event records	ZV10014	[V]Personal history of malignant neoplasm of large intestine
42040	GP clinical event records	ZV10017	[V]Personal history of malignant neoplasm of rectum
42040	GP clinical event records	XE1vV	Malignant neoplasm of colon NOS
42040	GP clinical event records	XaFsw	Hereditary nonpolyposis colon cancer
40006	Type of cancer: ICD10	C18	Malignant neoplasm of colon
40006	Type of cancer: ICD10	C19	Malignant neoplasm of rectosigmoid junction
40006	Type of cancer: ICD10	C20	Malignant neoplasm of rectum
40006	Type of cancer: ICD10	C21	Malignant neoplasm of anus and anal canal