Metadata

Name Primary Malignancy of Brain, Other CNS and Intracranial (pri_brain)
Category Cancers
Sex
Adult Yes
UUID 66a38f33-7f86-4196-ab8e-b9b5da698db4
Definition A neoplasm (disease) that involves the brain.

Ontologies

Disease Ontology (DOID) DOID_1319
GWAS Catalogue EFO_0005543
MeSH D001932
SNOMED-CT 126952004
FinnGen C3_BRAIN

Key Summary Statistics

Cases from any source

Total 1578
Female (%) 731 (46%)
Male (%) 847 (54%)

Year first recorded

pri_brain year of first event

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Cross-sourced pri_brain cases

Incidence & prevalence

Sex and age-stratified incidence and prevalence of pri_brain

Baseline prevalence stratified by sex

Female 7.54 (5.7,9.39)
Male 8.96 (6.77,11.15)

Incidence stratified by sex

Female 1.23 (0.94,1.52)
Male 2.0 (1.6,2.4)

Incidence stratified by age

Ages 40-44 0.7 (0.18,1.23)
Ages 45-49 0.67 (0.23,1.1)
Ages 50-54 1.14 (0.61,1.67)
Ages 55-59 1.61 (1.04,2.18)
Ages 60-64 2.11 (1.55,2.67)
Ages 65-69 2.26 (1.6,2.92)

Period prevalence

Methods

Comparison with general population

Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)

CALIBER and UKB pri_brain prevalence comparison for multiple age groups

Population Ages 40-49 Ages 50-59 Ages 60-69
UK Biobank 9 (7,13) 14 (11,17) 17 (14,20)
CALIBER 8 (8,9) 12 (11,13) 17 (15,18)

Stratified by age and Townsend deprivation status

Deprivation status Ages 40-49 Ages 50-59 Ages 60-69
Least deprived 13(6,24) 17(10,26) 18(13,25)
Low 12(5,24) 10(5,18) 14(9,20)
Medium 2(0,8) 17(10,25) 17(11,24)
High 11(5,21) 14(9,22) 16(11,24)
Most deprived 9(4,17) 13(8,20) 21(15,30)

Stratified by age and country

Country Ages 40-49 Ages 50-59 Ages 60-69
England 9(6,13) 15(11,18) 16(14,20)
Scotland 6(1,17) 10(5,19) 21(13,32)
Wales 24(10,49) 16(7,31) 18(9,31)

Risk factors analysis

‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.

Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method

N=153944, Events=165

Factor Level Hazard Ratio P value
BMI overweight 0.93 (0.64, 1.33) 0.683
BMI obese 0.99 (0.66, 1.49) 0.954
BMI underweight 0 (0, Inf) 0.994
smoking previous 1.57 (1.13, 2.18) 0.00649
smoking current 1.16 (0.66, 2.02) 0.611
hypertension yes 0.69 (0.47, 1.01) 0.0533

Definition

UK Biobank field id Description Code Value
20001 Cancer code, self-reported 1032 brain cancer / primary malignant brain tumour
20001 Cancer code, self-reported 1033 spinal cord or cranial nerve cancer
41202 Diagnoses - main ICD10 C70 Malignant neoplasm of meninges
41202 Diagnoses - main ICD10 C71 Malignant neoplasm of brain
41202 Diagnoses - main ICD10 C72 Malignant neoplasm of spinal cord, cranial nerves and other parts of central nervous system
41202 Diagnoses - main ICD10 C75.1 Malignant neoplasm: Pituitary gland
41202 Diagnoses - main ICD10 C75.2 Malignant neoplasm: Craniopharyngeal duct
41202 Diagnoses - main ICD10 C75.3 Malignant neoplasm: Pineal gland
41202 Diagnoses - main ICD10 C75.4 Malignant neoplasm: Carotid body
41202 Diagnoses - main ICD10 C75.5 Malignant neoplasm: Aortic body and other paraganglia
41204 Diagnoses - secondary ICD10 C70 Malignant neoplasm of meninges
41204 Diagnoses - secondary ICD10 C71 Malignant neoplasm of brain
41204 Diagnoses - secondary ICD10 C72 Malignant neoplasm of spinal cord, cranial nerves and other parts of central nervous system
41204 Diagnoses - secondary ICD10 C75.1 Malignant neoplasm: Pituitary gland
41204 Diagnoses - secondary ICD10 C75.2 Malignant neoplasm: Craniopharyngeal duct
41204 Diagnoses - secondary ICD10 C75.3 Malignant neoplasm: Pineal gland
41204 Diagnoses - secondary ICD10 C75.4 Malignant neoplasm: Carotid body
41204 Diagnoses - secondary ICD10 C75.5 Malignant neoplasm: Aortic body and other paraganglia
40001 Underlying (primary) cause of death: ICD10 C70 Malignant neoplasm of meninges
40001 Underlying (primary) cause of death: ICD10 C71 Malignant neoplasm of brain
40001 Underlying (primary) cause of death: ICD10 C72 Malignant neoplasm of spinal cord, cranial nerves and other parts of central nervous system
40001 Underlying (primary) cause of death: ICD10 C75.1 Malignant neoplasm: Pituitary gland
40001 Underlying (primary) cause of death: ICD10 C75.2 Malignant neoplasm: Craniopharyngeal duct
40001 Underlying (primary) cause of death: ICD10 C75.3 Malignant neoplasm: Pineal gland
40001 Underlying (primary) cause of death: ICD10 C75.4 Malignant neoplasm: Carotid body
40001 Underlying (primary) cause of death: ICD10 C75.5 Malignant neoplasm: Aortic body and other paraganglia
40002 Contributory (secondary) causes of death: ICD10 C70 Malignant neoplasm of meninges
40002 Contributory (secondary) causes of death: ICD10 C71 Malignant neoplasm of brain
40002 Contributory (secondary) causes of death: ICD10 C72 Malignant neoplasm of spinal cord, cranial nerves and other parts of central nervous system
40002 Contributory (secondary) causes of death: ICD10 C75.1 Malignant neoplasm: Pituitary gland
40002 Contributory (secondary) causes of death: ICD10 C75.2 Malignant neoplasm: Craniopharyngeal duct
40002 Contributory (secondary) causes of death: ICD10 C75.3 Malignant neoplasm: Pineal gland
40002 Contributory (secondary) causes of death: ICD10 C75.4 Malignant neoplasm: Carotid body
40002 Contributory (secondary) causes of death: ICD10 C75.5 Malignant neoplasm: Aortic body and other paraganglia
42040 GP clinical event records B510000 Malignant neoplasm of basal ganglia
42040 GP clinical event records B510100 Malignant neoplasm of cerebral cortex
42040 GP clinical event records B510300 Malignant neoplasm of globus pallidus
42040 GP clinical event records B510400 Malignant neoplasm of hypothalamus
42040 GP clinical event records B510500 Malignant neoplasm of thalamus
42040 GP clinical event records B510.00 Malignant neoplasm cerebrum (excluding lobes and ventricles)
42040 GP clinical event records B510z00 Malignant neoplasm of cerebrum NOS
42040 GP clinical event records B511.00 Malignant neoplasm of frontal lobe
42040 GP clinical event records B512000 Malignant neoplasm of hippocampus
42040 GP clinical event records B512.00 Malignant neoplasm of temporal lobe
42040 GP clinical event records B512z00 Malignant neoplasm of temporal lobe NOS
42040 GP clinical event records B513.00 Malignant neoplasm of parietal lobe
42040 GP clinical event records B514.00 Malignant neoplasm of occipital lobe
42040 GP clinical event records B515000 Malignant neoplasm of choroid plexus
42040 GP clinical event records B515.00 Malignant neoplasm of cerebral ventricles
42040 GP clinical event records B516.00 Malignant neoplasm of cerebellum
42040 GP clinical event records B517000 Malignant neoplasm of cerebral peduncle
42040 GP clinical event records B517100 Malignant neoplasm of medulla oblongata
42040 GP clinical event records B517200 Malignant neoplasm of midbrain
42040 GP clinical event records B517300 Malignant neoplasm of pons
42040 GP clinical event records B517.00 Malignant neoplasm of brain stem
42040 GP clinical event records B517z00 Malignant neoplasm of brain stem NOS
42040 GP clinical event records B51..00 Malignant neoplasm of brain
42040 GP clinical event records B51..11 Cerebral tumour - malignant
42040 GP clinical event records B51y000 Malignant neoplasm of corpus callosum
42040 GP clinical event records B51y200 Malignant neoplasm, overlapping lesion of brain
42040 GP clinical event records B51y.00 Malignant neoplasm of other parts of brain
42040 GP clinical event records B51yz00 Malignant neoplasm of other part of brain NOS
42040 GP clinical event records B51z.00 Malignant neoplasm of brain NOS
42040 GP clinical event records B520000 Malignant neoplasm of olfactory bulb
42040 GP clinical event records B520100 Malignant neoplasm of optic nerve
42040 GP clinical event records B520200 Malignant neoplasm of acoustic nerve
42040 GP clinical event records B520.00 Malignant neoplasm of cranial nerves
42040 GP clinical event records B520z00 Malignant neoplasm of cranial nerves NOS
42040 GP clinical event records B521200 Malignant neoplasm of cerebral pia mater
42040 GP clinical event records B521.00 Malignant neoplasm of cerebral meninges
42040 GP clinical event records B521z00 Malignant neoplasm of cerebral meninges NOS
42040 GP clinical event records B522.00 Malignant neoplasm of spinal cord
42040 GP clinical event records B523.00 Malignant neoplasm of spinal meninges
42040 GP clinical event records B523z00 Malignant neoplasm of spinal meninges NOS
42040 GP clinical event records B525.00 Malignant neoplasm of cauda equina
42040 GP clinical event records B52W.00 Malig neopl, overlap lesion brain & other part of CNS
42040 GP clinical event records B52X.00 Malignant neoplasm of meninges, unspecified
42040 GP clinical event records B542000 Malignant neoplasm of pituitary gland
42040 GP clinical event records B542100 Malignant neoplasm of craniopharyngeal duct
42040 GP clinical event records B542.00 Malignant neoplasm pituitary gland and craniopharyngeal duct
42040 GP clinical event records B542z00 Malig neop pituitary gland or craniopharyngeal duct NOS
42040 GP clinical event records B543.00 Malignant neoplasm of pineal gland
42040 GP clinical event records B544.00 Malignant neoplasm of carotid body
42040 GP clinical event records B545000 Malignant neoplasm of glomus jugulare
42040 GP clinical event records B545100 Malignant neoplasm of aortic body
42040 GP clinical event records B545200 Malignant neoplasm of coccygeal body
42040 GP clinical event records B545.00 Malignant neoplasm of aortic body and other paraganglia
42040 GP clinical event records B545z00 Malignant neoplasm of aortic body or paraganglia NOS
42040 GP clinical event records BBbB.00 [M]Astrocytoma NOS
42040 GP clinical event records BBbB.11 [M]Astrocytic glioma
42040 GP clinical event records BBbC.00 [M]Astrocytoma, anaplastic type
42040 GP clinical event records BBbE.00 [M]Gemistocytic astrocytoma
42040 GP clinical event records BBbF.00 [M]Fibrillary astrocytoma
42040 GP clinical event records BBbG.00 [M]Pilocytic astrocytoma
42040 GP clinical event records BBbG.11 [M]Juvenile astrocytoma
42040 GP clinical event records BBbG.12 [M]Piloid astrocytoma
42040 GP clinical event records BBbH.00 [M]Spongioblastoma NOS
42040 GP clinical event records BBbK.00 [M]Astroblastoma
42040 GP clinical event records BBbL.00 [M]Glioblastoma NOS
42040 GP clinical event records BBbL.11 [M]Glioblastoma multiforme
42040 GP clinical event records BBbM.00 [M]Giant cell glioblastoma
42040 GP clinical event records BBbQ.00 [M]Oligodendroglioma NOS
42040 GP clinical event records BBbR.00 [M]Oligodendroglioma, anaplastic type
42040 GP clinical event records BBbS.00 [M]Oligodendroblastoma
42040 GP clinical event records BBbT.00 [M]Medulloblastoma NOS
42040 GP clinical event records BBbU.00 [M]Desmoplastic medulloblastoma
42040 GP clinical event records BBbV.00 [M]Medullomyoblastoma
42040 GP clinical event records BBbW.00 [M]Cerebellar sarcoma NOS
42040 GP clinical event records BBbz.00 [M]Glioma NOS
42040 GP clinical event records BBbZ.00 [M]Pleomorphic xanthoastrocytoma
42040 GP clinical event records BBc2.00 [M]Medulloepithelioma NOS
42040 GP clinical event records BBc6.11 [M]Glioneuroma
42040 GP clinical event records BBc7.11 [M]Neuroastrocytoma
42040 GP clinical event records BBcA.00 [M]Olfactory neurogenic tumour
42040 GP clinical event records BBd2.00 [M]Meningioma, malignant
42040 GP clinical event records BBd2.12 [M]Meningothelial sarcoma
42040 GP clinical event records BBdA.00 [M]Papillary meningioma
42040 GP clinical event records ByuA000 [X]Malignant neoplasm/other and unspecified cranial nerves
42040 GP clinical event records ByuA100 [X]Malignant neoplasm/central nervous system, unspecified
42040 GP clinical event records ByuA200 [X]Malignant neoplasm of meninges, unspecified
42040 GP clinical event records ByuA300 [X]Malig neopl, overlap lesion brain & other part of CNS
42040 GP clinical event records ZV10y12 [V]Personal history of malignant neoplasm of brain
42040 GP clinical event records XE1wb [M]Glioblastoma NOS
42040 GP clinical event records XaC1Q Malignant neoplasm, overlapping lesion of brain
40006 Type of cancer: ICD10 C70 Malignant neoplasm of meninges
40006 Type of cancer: ICD10 C71 Malignant neoplasm of brain
40006 Type of cancer: ICD10 C72 Malignant neoplasm of spinal cord, cranial nerves and other parts of central nervous system
40006 Type of cancer: ICD10 C75.1 Malignant neoplasm: Pituitary gland
40006 Type of cancer: ICD10 C75.2 Malignant neoplasm: Craniopharyngeal duct
40006 Type of cancer: ICD10 C75.3 Malignant neoplasm: Pineal gland
40006 Type of cancer: ICD10 C75.4 Malignant neoplasm: Carotid body
40006 Type of cancer: ICD10 C75.5 Malignant neoplasm: Aortic body and other paraganglia