Primary Malignancy of Breast

Metadata

Name	Primary Malignancy of Breast (pri_breast)
Category	Cancers
Sex
Adult	Yes
UUID	b5f4347d-e15a-4850-a4ac-05c35b369b4e
Definition	A thoracic cancer that originates in the mammary gland.

Ontologies

Disease Ontology (DOID)	DOID_1612
GWAS Catalogue	EFO_0000305
MeSH	D001943
SNOMED-CT	254837009
FinnGen	C3_BREAST

Key Summary Statistics

Cases from any source

Total	23016
Female (%)	22846 (99%)
Male (%)	170 (1%)

Year first recorded

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Incidence & prevalence

Baseline prevalence stratified by sex

Female	431.9 (418.22,445.58)
Male	3.36 (2.02,4.7)

Incidence stratified by sex

Female	37.24 (35.61,38.87)
Male	0.27 (0.12,0.42)

Incidence stratified by age

Ages 40-44	14.92 (12.51,17.34)
Ages 45-49	19.13 (16.78,21.48)
Ages 50-54	16.91 (14.86,18.96)
Ages 55-59	19.93 (17.91,21.96)
Ages 60-64	24.24 (22.31,26.17)
Ages 65-69	19.76 (17.77,21.75)

Period prevalence

Methods

Comparison with general population

Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)

Population	Ages 40-49	Ages 50-59	Ages 60-69
UK Biobank	157 (145,168)	261 (249,272)	405 (393,418)
CALIBER	100 (97,102)	209 (205,214)	350 (344,355)

Stratified by age and Townsend deprivation status

Deprivation status	Ages 40-49	Ages 50-59	Ages 60-69
Least deprived	170(142,201)	285(258,313)	416(389,445)
Low	163(136,194)	261(235,288)	403(377,432)
Medium	167(140,196)	238(214,264)	392(366,421)
High	161(137,188)	265(240,292)	417(388,447)
Most deprived	128(108,152)	254(229,281)	396(367,427)

Stratified by age and country

Country	Ages 40-49	Ages 50-59	Ages 60-69
England	158(146,172)	266(253,280)	406(392,420)
Scotland	159(128,195)	239(209,271)	397(362,434)
Wales	133(97,178)	240(203,283)	416(370,465)

Risk factors analysis

‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.

Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method

N=153944, Events=165

Factor	Level	Hazard Ratio	P value
BMI	overweight	0.93 (0.64, 1.33)	0.683
BMI	obese	0.99 (0.66, 1.49)	0.954
BMI	underweight	0 (0, Inf)	0.994
smoking	previous	1.57 (1.13, 2.18)	0.00649
smoking	current	1.16 (0.66, 2.02)	0.611
hypertension	yes	0.69 (0.47, 1.01)	0.0533

Definition

UK Biobank field id	Description	Code	Value
20001	Cancer code, self-reported	1002	breast cancer
41202	Diagnoses - main ICD10	C50	Malignant neoplasm of breast
41202	Diagnoses - main ICD10	D05	Carcinoma in situ of breast
41204	Diagnoses - secondary ICD10	C50	Malignant neoplasm of breast
41204	Diagnoses - secondary ICD10	D05	Carcinoma in situ of breast
40001	Underlying (primary) cause of death: ICD10	C50	Malignant neoplasm of breast
40001	Underlying (primary) cause of death: ICD10	D05	Carcinoma in situ of breast
40002	Contributory (secondary) causes of death: ICD10	C50	Malignant neoplasm of breast
40002	Contributory (secondary) causes of death: ICD10	D05	Carcinoma in situ of breast
42040	GP clinical event records	B340000	Malignant neoplasm of nipple of female breast
42040	GP clinical event records	B340100	Malignant neoplasm of areola of female breast
42040	GP clinical event records	B340.00	Malignant neoplasm of nipple and areola of female breast
42040	GP clinical event records	B340z00	Malignant neoplasm of nipple or areola of female breast NOS
42040	GP clinical event records	B341.00	Malignant neoplasm of central part of female breast
42040	GP clinical event records	B342.00	Malignant neoplasm of upper-inner quadrant of female breast
42040	GP clinical event records	B343.00	Malignant neoplasm of lower-inner quadrant of female breast
42040	GP clinical event records	B344.00	Malignant neoplasm of upper-outer quadrant of female breast
42040	GP clinical event records	B345.00	Malignant neoplasm of lower-outer quadrant of female breast
42040	GP clinical event records	B346.00	Malignant neoplasm of axillary tail of female breast
42040	GP clinical event records	B347.00	Malignant neoplasm, overlapping lesion of breast
42040	GP clinical event records	B34..00	Malignant neoplasm of female breast
42040	GP clinical event records	B34..11	Ca female breast
42040	GP clinical event records	B34y000	Malignant neoplasm of ectopic site of female breast
42040	GP clinical event records	B34y.00	Malignant neoplasm of other site of female breast
42040	GP clinical event records	B34yz00	Malignant neoplasm of other site of female breast NOS
42040	GP clinical event records	B34z.00	Malignant neoplasm of female breast NOS
42040	GP clinical event records	B350000	Malignant neoplasm of nipple of male breast
42040	GP clinical event records	B350100	Malignant neoplasm of areola of male breast
42040	GP clinical event records	B350.00	Malignant neoplasm of nipple and areola of male breast
42040	GP clinical event records	B35..00	Malignant neoplasm of male breast
42040	GP clinical event records	B35z000	Malignant neoplasm of ectopic site of male breast
42040	GP clinical event records	B35z.00	Malignant neoplasm of other site of male breast
42040	GP clinical event records	B35zz00	Malignant neoplasm of male breast NOS
42040	GP clinical event records	B36..00	Local recurrence of malignant tumour of breast
42040	GP clinical event records	B830000	Lobular carcinoma in situ of breast
42040	GP clinical event records	B830100	Intraductal carcinoma in situ of breast
42040	GP clinical event records	B830.00	Carcinoma in situ of breast
42040	GP clinical event records	BB91.00	[M]Infiltrating duct carcinoma
42040	GP clinical event records	BB91.11	[M]Duct carcinoma NOS
42040	GP clinical event records	BB91000	[M]Intraductal papillary adenocarcinoma with invasion
42040	GP clinical event records	BB96.00	[M]Noninfiltrating intraductal papillary adenocarcinoma
42040	GP clinical event records	BB91100	[M]Infiltrating duct and lobular carcinoma
42040	GP clinical event records	BB92.00	[M]Comedocarcinoma, noninfiltrating
42040	GP clinical event records	BB93.00	[M]Comedocarcinoma NOS
42040	GP clinical event records	BB94.00	[M]Juvenile breast carcinoma
42040	GP clinical event records	BB94.11	[M]Secretory breast carcinoma
42040	GP clinical event records	BB9J.00	[M]Paget’s disease, mammary
42040	GP clinical event records	BB9J.11	[M]Paget’s disease, breast
42040	GP clinical event records	BB9K000	[M]Paget’s disease and intraductal carcinoma of breast
42040	GP clinical event records	BB9K.00	[M]Paget’s disease and infiltrating breast duct carcinoma
42040	GP clinical event records	BB9M.00	[M]Intracystic carcinoma NOS
42040	GP clinical event records	Byu6.00	[X]Malignant neoplasm of breast
42040	GP clinical event records	ByuFG00	[X]Other carcinoma in situ of breast
42040	GP clinical event records	ZV10300	[V]Personal history of malignant neoplasm of breast
42040	GP clinical event records	X78WW	Intraductal carcinoma in situ of breast
42040	GP clinical event records	X78WV	Lobular carcinoma in situ of breast
42040	GP clinical event records	XaFr8	Local recurrence of malignant tumour of breast
40006	Type of cancer: ICD10	C50	Malignant neoplasm of breast
40006	Type of cancer: ICD10	D05	Carcinoma in situ of breast