Metadata
| Name | Primary Malignancy of Cervical (pri_cervical) |
| Category | Cancers |
| Sex | |
| Adult | Yes |
| UUID | 928e6f96-6810-4bca-8ad6-4d2be1275a74 |
| Definition | A carcinoma arising from either the exocervical squamous epithelium or the endocervical glandular epithelium. |
Ontologies
| Disease Ontology (DOID) | DOID_4362 |
| GWAS Catalogue | EFO_0001061 |
| MeSH | D002583 |
| SNOMED-CT | 363354003 |
| FinnGen | C3_CERVIX_UTERI |
Key Summary Statistics
Cases from any source
| Total | 2444 |
| Female (%) | 2444 (100%) |
| Male (%) | 0 (0%) |
Year first recorded
Cases linked in all UK Biobank sources
Cross-source concordance
Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.
Incidence & prevalence
Baseline prevalence stratified by sex
| Female | 85.34 (79.15,91.53) |
| Male | 0.0 (0.0,0.0) |
Incidence stratified by sex
| Female | 0.64 (0.43,0.85) |
| Male | 0.0 (0.0,0.0) |
Incidence stratified by age
| Ages 40-44 | 0.3 (-0.04,0.65) |
| Ages 45-49 | 0.37 (0.05,0.7) |
| Ages 50-54 | 0.38 (0.08,0.69) |
| Ages 55-59 | 0.42 (0.13,0.71) |
| Ages 60-64 | 0.42 (0.17,0.67) |
| Ages 65-69 | 0.15 (-0.02,0.32) |
Period prevalence
Methods
Comparison with general population
Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)
| Population | Ages 40-49 | Ages 50-59 | Ages 60-69 |
| UK Biobank | 15 (11,18) | 16 (14,20) | 15 (13,18) |
| CALIBER | 23 (22,25) | 31 (28,33) | 36 (33,39) |
Stratified by age and Townsend deprivation status
| Deprivation status | Ages 40-49 | Ages 50-59 | Ages 60-69 |
| Least deprived | 15(8,26) | 15(9,22) | 11(7,16) |
| Low | 14(7,25) | 20(14,29) | 17(12,23) |
| Medium | 8(3,17) | 17(11,25) | 13(8,19) |
| High | 17(10,27) | 13(8,20) | 16(11,23) |
| Most deprived | 18(11,27) | 18(11,26) | 22(15,30) |
Stratified by age and country
| Country | Ages 40-49 | Ages 50-59 | Ages 60-69 |
| England | 13(10,17) | 16(13,19) | 15(12,18) |
| Scotland | 26(15,43) | 22(14,33) | 17(11,27) |
| Wales | 12(3,31) | 13(6,26) | 15(7,27) |
Definition
| UK Biobank field id | Description | Code | Value |
|---|---|---|---|
| 20001 | Cancer code, self-reported | 1041 | cervical cancer |
| 41202 | Diagnoses - main ICD10 | C53 | Malignant neoplasm of cervix uteri |
| 41204 | Diagnoses - secondary ICD10 | C53 | Malignant neoplasm of cervix uteri |
| 40001 | Underlying (primary) cause of death: ICD10 | C53 | Malignant neoplasm of cervix uteri |
| 40002 | Contributory (secondary) causes of death: ICD10 | C53 | Malignant neoplasm of cervix uteri |
| 42040 | GP clinical event records | B410000 | Malignant neoplasm of endocervical canal |
| 42040 | GP clinical event records | B410100 | Malignant neoplasm of endocervical gland |
| 42040 | GP clinical event records | B410.00 | Malignant neoplasm of endocervix |
| 42040 | GP clinical event records | B410z00 | Malignant neoplasm of endocervix NOS |
| 42040 | GP clinical event records | B411.00 | Malignant neoplasm of exocervix |
| 42040 | GP clinical event records | B412.00 | Malignant neoplasm, overlapping lesion of cervix uteri |
| 42040 | GP clinical event records | B41..00 | Malignant neoplasm of cervix uteri |
| 42040 | GP clinical event records | B41..11 | Cervical carcinoma (uterus) |
| 42040 | GP clinical event records | B41y000 | Malignant neoplasm of cervical stump |
| 42040 | GP clinical event records | B41y100 | Malignant neoplasm of squamocolumnar junction of cervix |
| 42040 | GP clinical event records | B41y.00 | Malignant neoplasm of other site of cervix |
| 42040 | GP clinical event records | B41yz00 | Malignant neoplasm of other site of cervix NOS |
| 42040 | GP clinical event records | B41z.00 | Malignant neoplasm of cervix uteri NOS |
| 42040 | GP clinical event records | ZV10411 | [V]Personal history of malignant neoplasm of cervix uteri |
| 40006 | Type of cancer: ICD10 | C53 | Malignant neoplasm of cervix uteri |