Metadata
| Name | Primary Malignancy of Kidney and Ureter (pri_kidney) |
| Category | Cancers |
| Sex | |
| Adult | Yes |
| UUID | da606197-ae5f-4af6-b6e7-a82f3554818f |
| Definition | A urinary system cancer that is located_in the kidney. |
Ontologies
| Disease Ontology (DOID) | DOID_263 |
| GWAS Catalogue | EFO_0000681 |
| MeSH | D007680 |
| SNOMED-CT | 126880001 |
| FinnGen | C3_URETER |
Key Summary Statistics
Cases from any source
| Total | 2871 |
| Female (%) | 1042 (36%) |
| Male (%) | 1829 (64%) |
Year first recorded
Cases linked in all UK Biobank sources
Cross-source concordance
Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.
Incidence & prevalence
Baseline prevalence stratified by sex
| Female | 8.84 (6.84,10.84) |
| Male | 24.36 (20.74,27.97) |
Incidence stratified by sex
| Female | 2.06 (1.68,2.43) |
| Male | 4.52 (3.91,5.12) |
Incidence stratified by age
| Ages 40-44 | 1.01 (0.38,1.63) |
| Ages 45-49 | 1.56 (0.89,2.22) |
| Ages 50-54 | 1.96 (1.27,2.66) |
| Ages 55-59 | 2.97 (2.2,3.74) |
| Ages 60-64 | 4.39 (3.58,5.19) |
| Ages 65-69 | 4.94 (3.96,5.91) |
Period prevalence
Methods
Comparison with general population
Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)
| Population | Ages 40-49 | Ages 50-59 | Ages 60-69 |
| UK Biobank | 9 (6,12) | 24 (21,29) | 46 (41,50) |
| CALIBER | 7 (6,7) | 17 (16,18) | 39 (37,41) |
Stratified by age and Townsend deprivation status
| Deprivation status | Ages 40-49 | Ages 50-59 | Ages 60-69 |
| Least deprived | 2(0,9) | 28(19,39) | 43(34,53) |
| Low | 4(1,13) | 21(14,31) | 50(40,61) |
| Medium | 14(6,25) | 21(14,31) | 56(46,68) |
| High | 13(7,24) | 20(13,29) | 41(32,52) |
| Most deprived | 10(5,18) | 31(22,43) | 37(28,48) |
Stratified by age and country
| Country | Ages 40-49 | Ages 50-59 | Ages 60-69 |
| England | 9(6,12) | 25(20,29) | 44(39,49) |
| Scotland | 12(4,25) | 26(16,39) | 57(43,74) |
| Wales | 7(1,24) | 20(9,36) | 52(36,72) |
Risk factors analysis
‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.
Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method
N=153944, Events=165
| Factor | Level | Hazard Ratio | P value |
| BMI | overweight | 0.93 (0.64, 1.33) | 0.683 |
| BMI | obese | 0.99 (0.66, 1.49) | 0.954 |
| BMI | underweight | 0 (0, Inf) | 0.994 |
| smoking | previous | 1.57 (1.13, 2.18) | 0.00649 |
| smoking | current | 1.16 (0.66, 2.02) | 0.611 |
| hypertension | yes | 0.69 (0.47, 1.01) | 0.0533 |
Definition
| UK Biobank field id | Description | Code | Value |
|---|---|---|---|
| 20001 | Cancer code, self-reported | 1034 | kidney/renal cell cancer |
| 20001 | Cancer code, self-reported | 1036 | other cancer of urinary tract |
| 41202 | Diagnoses - main ICD10 | C64 | Malignant neoplasm of kidney, except renal pelvis |
| 41202 | Diagnoses - main ICD10 | C65 | Malignant neoplasm of renal pelvis |
| 41202 | Diagnoses - main ICD10 | C66 | Malignant neoplasm of ureter |
| 41204 | Diagnoses - secondary ICD10 | C64 | Malignant neoplasm of kidney, except renal pelvis |
| 41204 | Diagnoses - secondary ICD10 | C65 | Malignant neoplasm of renal pelvis |
| 41204 | Diagnoses - secondary ICD10 | C66 | Malignant neoplasm of ureter |
| 40001 | Underlying (primary) cause of death: ICD10 | C64 | Malignant neoplasm of kidney, except renal pelvis |
| 40001 | Underlying (primary) cause of death: ICD10 | C65 | Malignant neoplasm of renal pelvis |
| 40001 | Underlying (primary) cause of death: ICD10 | C66 | Malignant neoplasm of ureter |
| 40002 | Contributory (secondary) causes of death: ICD10 | C64 | Malignant neoplasm of kidney, except renal pelvis |
| 40002 | Contributory (secondary) causes of death: ICD10 | C65 | Malignant neoplasm of renal pelvis |
| 40002 | Contributory (secondary) causes of death: ICD10 | C66 | Malignant neoplasm of ureter |
| 42040 | GP clinical event records | B4A0000 | Hypernephroma |
| 42040 | GP clinical event records | B4A0.00 | Malignant neoplasm of kidney parenchyma |
| 42040 | GP clinical event records | B4A1000 | Malignant neoplasm of renal calyces |
| 42040 | GP clinical event records | B4A1100 | Malignant neoplasm of ureteropelvic junction |
| 42040 | GP clinical event records | B4A1.00 | Malignant neoplasm of renal pelvis |
| 42040 | GP clinical event records | B4A1z00 | Malignant neoplasm of renal pelvis NOS |
| 42040 | GP clinical event records | B4A2.00 | Malignant neoplasm of ureter |
| 42040 | GP clinical event records | B4A..11 | Renal malignant neoplasm |
| 42040 | GP clinical event records | BB5a000 | [M]Renal cell carcinoma |
| 42040 | GP clinical event records | BB5a011 | [M]Grawitz tumour |
| 42040 | GP clinical event records | BB5a012 | [M]Hypernephroma |
| 42040 | GP clinical event records | ZV10512 | [V]Personal history of malignant neoplasm of kidney |
| 42040 | GP clinical event records | ZV10513 | [V]Personal history of malignant neoplasm of kidney |
| 42040 | GP clinical event records | XE2vQ | Malignant neoplasm of kidney and other unspecified urinary organs |
| 40006 | Type of cancer: ICD10 | C64 | Malignant neoplasm of kidney, except renal pelvis |
| 40006 | Type of cancer: ICD10 | C65 | Malignant neoplasm of renal pelvis |
| 40006 | Type of cancer: ICD10 | C66 | Malignant neoplasm of ureter |