Primary Malignancy of Liver

Metadata

Name	Primary Malignancy of Liver (pri_liver)
Category	Cancers
Sex
Adult	Yes
UUID	778ec151-80c0-4607-8f78-e428855bf502
Definition	nuA benign or malignant epithelial neoplasm that affects the liver parenchyma and intrahepatic bile ducts.

Ontologies

Disease Ontology (DOID)	DOID_3571
GWAS Catalogue	MONDO_0002691
MeSH	D008113
SNOMED-CT	93870000
FinnGen	C3_LIVER_INTRAHEPATIC_BILE_DUCTS

Key Summary Statistics

Cases from any source

Total	893
Female (%)	303 (34%)
Male (%)	590 (66%)

Year first recorded

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Incidence & prevalence

Baseline prevalence stratified by sex

Female	2.83 (1.7,3.96)
Male	5.88 (4.1,7.66)

Incidence stratified by sex

Female	0.35 (0.2,0.51)
Male	0.95 (0.67,1.22)

Incidence stratified by age

Ages 40-44	0.1 (-0.1,0.3)
Ages 45-49	0.0 (0.0,0.0)
Ages 50-54	0.38 (0.08,0.68)
Ages 55-59	0.52 (0.2,0.84)
Ages 60-64	0.92 (0.55,1.29)
Ages 65-69	1.21 (0.72,1.69)

Period prevalence

Methods

Comparison with general population

Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)

Population	Ages 40-49	Ages 50-59	Ages 60-69
UK Biobank	1 (0,2)	5 (3,7)	9 (7,11)
CALIBER	–	5 (5,6)	10 (9,11)

Stratified by age and Townsend deprivation status

Deprivation status	Ages 40-49	Ages 50-59	Ages 60-69
Least deprived	0(NaN,NaN)	2(0,7)	7(4,12)
Low	0(NaN,NaN)	3(1,8)	6(3,10)
Medium	1(0,6)	7(3,13)	9(5,14)
High	0(NaN,NaN)	6(2,12)	12(7,19)
Most deprived	3(1,8)	6(3,12)	9(5,15)

Stratified by age and country

Country	Ages 40-49	Ages 50-59	Ages 60-69
England	1(0,3)	5(3,8)	8(6,10)
Scotland	0(NaN,NaN)	3(1,10)	8(3,15)
Wales	0(NaN,NaN)	2(0,12)	16(8,29)

Definition

UK Biobank field id	Description	Code	Value
20001	Cancer code, self-reported	1024	liver/hepatocellular cancer
41202	Diagnoses - main ICD10	C22.0	Malignant neoplasm: Liver cell carcinoma
41202	Diagnoses - main ICD10	C22.2	Malignant neoplasm: Hepatoblastoma
41202	Diagnoses - main ICD10	C22.3	Malignant neoplasm: Angiosarcoma of liver
41202	Diagnoses - main ICD10	C22.4	Malignant neoplasm: Other sarcomas of liver
41202	Diagnoses - main ICD10	C22.7	Malignant neoplasm: Other specified carcinomas of liver
41202	Diagnoses - main ICD10	C22.9	Malignant neoplasm: Liver, unspecified
41204	Diagnoses - secondary ICD10	C22.0	Malignant neoplasm: Liver cell carcinoma
41204	Diagnoses - secondary ICD10	C22.2	Malignant neoplasm: Hepatoblastoma
41204	Diagnoses - secondary ICD10	C22.3	Malignant neoplasm: Angiosarcoma of liver
41204	Diagnoses - secondary ICD10	C22.4	Malignant neoplasm: Other sarcomas of liver
41204	Diagnoses - secondary ICD10	C22.7	Malignant neoplasm: Other specified carcinomas of liver
41204	Diagnoses - secondary ICD10	C22.9	Malignant neoplasm: Liver, unspecified
40001	Underlying (primary) cause of death: ICD10	C22.0	Malignant neoplasm: Liver cell carcinoma
40001	Underlying (primary) cause of death: ICD10	C22.2	Malignant neoplasm: Hepatoblastoma
40001	Underlying (primary) cause of death: ICD10	C22.3	Malignant neoplasm: Angiosarcoma of liver
40001	Underlying (primary) cause of death: ICD10	C22.4	Malignant neoplasm: Other sarcomas of liver
40001	Underlying (primary) cause of death: ICD10	C22.7	Malignant neoplasm: Other specified carcinomas of liver
40001	Underlying (primary) cause of death: ICD10	C22.9	Malignant neoplasm: Liver, unspecified
40002	Contributory (secondary) causes of death: ICD10	C22.0	Malignant neoplasm: Liver cell carcinoma
40002	Contributory (secondary) causes of death: ICD10	C22.2	Malignant neoplasm: Hepatoblastoma
40002	Contributory (secondary) causes of death: ICD10	C22.3	Malignant neoplasm: Angiosarcoma of liver
40002	Contributory (secondary) causes of death: ICD10	C22.4	Malignant neoplasm: Other sarcomas of liver
40002	Contributory (secondary) causes of death: ICD10	C22.7	Malignant neoplasm: Other specified carcinomas of liver
40002	Contributory (secondary) causes of death: ICD10	C22.9	Malignant neoplasm: Liver, unspecified
42040	GP clinical event records	B150000	Primary carcinoma of liver
42040	GP clinical event records	B150100	Hepatoblastoma of liver
42040	GP clinical event records	B150200	Primary angiosarcoma of liver
42040	GP clinical event records	B150300	Hepatocellular carcinoma
42040	GP clinical event records	B150.00	Primary malignant neoplasm of liver
42040	GP clinical event records	B150z00	Primary malignant neoplasm of liver NOS
42040	GP clinical event records	B152.00	Malignant neoplasm of liver unspecified
42040	GP clinical event records	BB5D500	[M]Hepatocellular carcinoma NOS
42040	GP clinical event records	BB5D511	[M]Hepatoma NOS
42040	GP clinical event records	BB5D512	[M]Hepatoma, malignant
42040	GP clinical event records	BB5D513	[M]Liver cell carcinoma
42040	GP clinical event records	BB5D700	[M]Combined hepatocellular carcinoma and cholangiocarcinoma
42040	GP clinical event records	BB5D711	[M]Hepatocholangiocarcinoma
42040	GP clinical event records	BB5D800	[M]Hepatocellular carcinoma, fibrolamellar
42040	GP clinical event records	Byu1100	[X]Other specified carcinomas of liver
42040	GP clinical event records	ZV10015	[V]Personal history of malignant neoplasm of liver
40006	Type of cancer: ICD10	C22.0	Malignant neoplasm: Liver cell carcinoma
40006	Type of cancer: ICD10	C22.2	Malignant neoplasm: Hepatoblastoma
40006	Type of cancer: ICD10	C22.3	Malignant neoplasm: Angiosarcoma of liver
40006	Type of cancer: ICD10	C22.4	Malignant neoplasm: Other sarcomas of liver
40006	Type of cancer: ICD10	C22.7	Malignant neoplasm: Other specified carcinomas of liver
40006	Type of cancer: ICD10	C22.9	Malignant neoplasm: Liver, unspecified