Primary Malignancy of Lung and trachea

Metadata

Name	Primary Malignancy of Lung and trachea (pri_lung)
Category	Cancers
Sex
Adult	Yes
UUID	49d08740-922a-47cd-b418-375da010e423
Definition	Malignant neoplasm of bronchus and lung.

Ontologies

Disease Ontology (DOID)	DOID_1325
GWAS Catalogue	EFO_0001071
MeSH	D008175
SNOMED-CT	93880001
FinnGen	C3_BRONCHUS_LUNG

Key Summary Statistics

Cases from any source

Total	6303
Female (%)	2949 (47%)
Male (%)	3354 (53%)

Year first recorded

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Incidence & prevalence

Baseline prevalence stratified by sex

Female	11.43 (9.16,13.71)
Male	26.6 (22.82,30.38)

Incidence stratified by sex

Female	6.03 (5.4,6.67)
Male	7.19 (6.43,7.96)

Incidence stratified by age

Ages 40-44	1.21 (0.52,1.89)
Ages 45-49	1.56 (0.89,2.22)
Ages 50-54	3.8 (2.84,4.77)
Ages 55-59	5.83 (4.75,6.91)
Ages 60-64	8.35 (7.24,9.46)
Ages 65-69	13.21 (11.61,14.81)

Period prevalence

Methods

Comparison with general population

Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)

Population	Ages 40-49	Ages 50-59	Ages 60-69
UK Biobank	9 (6,12)	32 (28,37)	67 (62,73)
CALIBER	9 (8,10)	38 (36,40)	108 (105,112)

Stratified by age and Townsend deprivation status

Deprivation status	Ages 40-49	Ages 50-59	Ages 60-69
Least deprived	5(1,14)	21(14,30)	46(37,57)
Low	6(2,15)	20(13,29)	40(31,50)
Medium	8(3,17)	26(18,37)	60(50,73)
High	15(8,25)	29(20,40)	78(66,93)
Most deprived	8(3,15)	63(50,78)	124(107,142)

Stratified by age and country

Country	Ages 40-49	Ages 50-59	Ages 60-69
England	8(6,12)	32(27,37)	65(59,71)
Scotland	9(3,20)	37(25,52)	75(60,93)
Wales	10(2,29)	24(13,41)	77(58,101)

Risk factors analysis

‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.

Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method

N=153944, Events=165

Factor	Level	Hazard Ratio	P value
BMI	overweight	0.93 (0.64, 1.33)	0.683
BMI	obese	0.99 (0.66, 1.49)	0.954
BMI	underweight	0 (0, Inf)	0.994
smoking	previous	1.57 (1.13, 2.18)	0.00649
smoking	current	1.16 (0.66, 2.02)	0.611
hypertension	yes	0.69 (0.47, 1.01)	0.0533

Definition

UK Biobank field id	Description	Code	Value
22180	Recent medication for lung cancer (not mesothelioma)	1	Yes
22140	Doctor diagnosed lung cancer (not mesothelioma)	1	Yes
20001	Cancer code, self-reported	1001	lung cancer
20001	Cancer code, self-reported	1006	larynx/throat cancer
41202	Diagnoses - main ICD10	C33	Malignant neoplasm of trachea
41202	Diagnoses - main ICD10	C34	Malignant neoplasm of bronchus and lung
41204	Diagnoses - secondary ICD10	C33	Malignant neoplasm of trachea
41204	Diagnoses - secondary ICD10	C34	Malignant neoplasm of bronchus and lung
40001	Underlying (primary) cause of death: ICD10	C33	Malignant neoplasm of trachea
40001	Underlying (primary) cause of death: ICD10	C34	Malignant neoplasm of bronchus and lung
40002	Contributory (secondary) causes of death: ICD10	C33	Malignant neoplasm of trachea
40002	Contributory (secondary) causes of death: ICD10	C34	Malignant neoplasm of bronchus and lung
42040	GP clinical event records	B220100	Malignant neoplasm of mucosa of trachea
42040	GP clinical event records	B220.00	Malignant neoplasm of trachea
42040	GP clinical event records	B220z00	Malignant neoplasm of trachea NOS
42040	GP clinical event records	B221000	Malignant neoplasm of carina of bronchus
42040	GP clinical event records	B221100	Malignant neoplasm of hilus of lung
42040	GP clinical event records	B221.00	Malignant neoplasm of main bronchus
42040	GP clinical event records	B221z00	Malignant neoplasm of main bronchus NOS
42040	GP clinical event records	B222000	Malignant neoplasm of upper lobe bronchus
42040	GP clinical event records	B222100	Malignant neoplasm of upper lobe of lung
42040	GP clinical event records	B222.00	Malignant neoplasm of upper lobe, bronchus or lung
42040	GP clinical event records	B222.11	Pancoast’s syndrome
42040	GP clinical event records	B222z00	Malignant neoplasm of upper lobe, bronchus or lung NOS
42040	GP clinical event records	B223000	Malignant neoplasm of middle lobe bronchus
42040	GP clinical event records	B223100	Malignant neoplasm of middle lobe of lung
42040	GP clinical event records	B223.00	Malignant neoplasm of middle lobe, bronchus or lung
42040	GP clinical event records	B223z00	Malignant neoplasm of middle lobe, bronchus or lung NOS
42040	GP clinical event records	B224000	Malignant neoplasm of lower lobe bronchus
42040	GP clinical event records	B224100	Malignant neoplasm of lower lobe of lung
42040	GP clinical event records	B224.00	Malignant neoplasm of lower lobe, bronchus or lung
42040	GP clinical event records	B224z00	Malignant neoplasm of lower lobe, bronchus or lung NOS
42040	GP clinical event records	B225.00	Malignant neoplasm of overlapping lesion of bronchus & lung
42040	GP clinical event records	B22..00	Malignant neoplasm of trachea, bronchus and lung
42040	GP clinical event records	B22y.00	Malignant neoplasm of other sites of bronchus or lung
42040	GP clinical event records	B22z.00	Malignant neoplasm of bronchus or lung NOS
42040	GP clinical event records	B22z.11	Lung cancer
42040	GP clinical event records	BB5S200	[M]Bronchiolo-alveolar adenocarcinoma
42040	GP clinical event records	BB5S211	[M]Alveolar cell carcinoma
42040	GP clinical event records	BB5S212	[M]Bronchiolar carcinoma
42040	GP clinical event records	BB5S400	[M]Alveolar adenocarcinoma
42040	GP clinical event records	Byu2000	[X]Malignant neoplasm of bronchus or lung, unspecified
42040	GP clinical event records	ZV10100	[V]Personal history of malig neop of trachea/bronchus/lung
42040	GP clinical event records	ZV10111	[V]Personal history of malignant neoplasm of bronchus
42040	GP clinical event records	ZV10112	[V]Personal history of malignant neoplasm of lung
42040	GP clinical event records	XE1vb	Malignant neoplasm of upper lobe, bronchus or lung
42040	GP clinical event records	XE1vc	Malignant neoplasm of bronchus or lung NOS
40006	Type of cancer: ICD10	C33	Malignant neoplasm of trachea
40006	Type of cancer: ICD10	C34	Malignant neoplasm of bronchus and lung