Primary Malignancy of Malignant Melanoma

Metadata

Name	Primary Malignancy of Malignant Melanoma (pri_melanoma)
Category	Cancers
Sex
Adult	Yes
UUID	a534cbbb-0b04-4347-8bf1-6eeeed899652
Definition	A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites.

Ontologies

Disease Ontology (DOID)	DOID_6846
GWAS Catalogue	EFO_0000756
MeSH	D008545
SNOMED-CT	2092003
FinnGen	C3_MELANOMA_SKIN

Key Summary Statistics

Cases from any source

Total	9592
Female (%)	5187 (54%)
Male (%)	4405 (46%)

Year first recorded

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Incidence & prevalence

Baseline prevalence stratified by sex

Female	126.72 (119.19,134.25)
Male	107.23 (99.68,114.79)

Incidence stratified by sex

Female	6.67 (5.99,7.34)
Male	7.97 (7.16,8.78)

Incidence stratified by age

Ages 40-44	3.24 (2.12,4.36)
Ages 45-49	4.03 (2.96,5.11)
Ages 50-54	5.95 (4.74,7.16)
Ages 55-59	6.84 (5.66,8.01)
Ages 60-64	9.45 (8.26,10.64)
Ages 65-69	10.09 (8.68,11.5)

Period prevalence

Methods

Comparison with general population

Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)

Population	Ages 40-49	Ages 50-59	Ages 60-69
UK Biobank	66 (58,74)	90 (83,98)	129 (122,137)
CALIBER	42 (40,44)	65 (62,67)	105 (101,108)

Stratified by age and Townsend deprivation status

Deprivation status	Ages 40-49	Ages 50-59	Ages 60-69
Least deprived	83(64,106)	104(88,123)	146(129,164)
Low	81(61,104)	111(93,131)	151(134,169)
Medium	65(48,85)	87(72,104)	133(117,150)
High	66(50,85)	86(71,104)	111(96,127)
Most deprived	44(32,58)	63(51,78)	97(83,114)

Stratified by age and country

Country	Ages 40-49	Ages 50-59	Ages 60-69
England	64(56,74)	83(75,91)	125(117,133)
Scotland	74(52,102)	102(82,126)	144(122,168)
Wales	64(39,99)	141(111,177)	153(126,186)

Risk factors analysis

‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.

Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method

N=153944, Events=165

Factor	Level	Hazard Ratio	P value
BMI	overweight	0.93 (0.64, 1.33)	0.683
BMI	obese	0.99 (0.66, 1.49)	0.954
BMI	underweight	0 (0, Inf)	0.994
smoking	previous	1.57 (1.13, 2.18)	0.00649
smoking	current	1.16 (0.66, 2.02)	0.611
hypertension	yes	0.69 (0.47, 1.01)	0.0533

Definition

UK Biobank field id	Description	Code	Value
20001	Cancer code, self-reported	1003	skin cancer
20001	Cancer code, self-reported	1059	malignant melanoma
41202	Diagnoses - main ICD10	C43	Malignant melanoma of skin
41204	Diagnoses - secondary ICD10	C43	Malignant melanoma of skin
40001	Underlying (primary) cause of death: ICD10	C43	Malignant melanoma of skin
40002	Contributory (secondary) causes of death: ICD10	C43	Malignant melanoma of skin
42040	GP clinical event records	1425000.0	H/O Malignant melanoma
42040	GP clinical event records	4M3..00	Breslow depth staging for melanoma
42040	GP clinical event records	4M70.00	Clark melanoma level 1
42040	GP clinical event records	4M71.00	Clark melanoma level 2
42040	GP clinical event records	4M72.00	Clark melanoma level 3
42040	GP clinical event records	4M73.00	Clark melanoma level 4
42040	GP clinical event records	4M74.00	Clark melanoma level 5
42040	GP clinical event records	7G03J00	Excision of melanoma
42040	GP clinical event records	B320.00	Malignant melanoma of lip
42040	GP clinical event records	B321.00	Malignant melanoma of eyelid including canthus
42040	GP clinical event records	B322000	Malignant melanoma of auricle (ear)
42040	GP clinical event records	B322100	Malignant melanoma of external auditory meatus
42040	GP clinical event records	B322.00	Malignant melanoma of ear and external auricular canal
42040	GP clinical event records	B322z00	Malignant melanoma of ear and external auricular canal NOS
42040	GP clinical event records	B323000	Malignant melanoma of external surface of cheek
42040	GP clinical event records	B323100	Malignant melanoma of chin
42040	GP clinical event records	B323200	Malignant melanoma of eyebrow
42040	GP clinical event records	B323300	Malignant melanoma of forehead
42040	GP clinical event records	B323400	Malignant melanoma of external surface of nose
42040	GP clinical event records	B323500	Malignant melanoma of temple
42040	GP clinical event records	B323.00	Malignant melanoma of other and unspecified parts of face
42040	GP clinical event records	B323z00	Malignant melanoma of face NOS
42040	GP clinical event records	B324000	Malignant melanoma of scalp
42040	GP clinical event records	B324100	Malignant melanoma of neck
42040	GP clinical event records	B324.00	Malignant melanoma of scalp and neck
42040	GP clinical event records	B324z00	Malignant melanoma of scalp and neck NOS
42040	GP clinical event records	B325000	Malignant melanoma of axilla
42040	GP clinical event records	B325100	Malignant melanoma of breast
42040	GP clinical event records	B325200	Malignant melanoma of buttock
42040	GP clinical event records	B325300	Malignant melanoma of groin
42040	GP clinical event records	B325400	Malignant melanoma of perianal skin
42040	GP clinical event records	B325500	Malignant melanoma of perineum
42040	GP clinical event records	B325600	Malignant melanoma of umbilicus
42040	GP clinical event records	B325700	Malignant melanoma of back
42040	GP clinical event records	B325800	Malignant melanoma of chest wall
42040	GP clinical event records	B325.00	Malignant melanoma of trunk (excluding scrotum)
42040	GP clinical event records	B325z00	Malignant melanoma of trunk, excluding scrotum, NOS
42040	GP clinical event records	B326000	Malignant melanoma of shoulder
42040	GP clinical event records	B326100	Malignant melanoma of upper arm
42040	GP clinical event records	B326200	Malignant melanoma of fore-arm
42040	GP clinical event records	B326300	Malignant melanoma of hand
42040	GP clinical event records	B326400	Malignant melanoma of finger
42040	GP clinical event records	B326500	Malignant melanoma of thumb
42040	GP clinical event records	B326.00	Malignant melanoma of upper limb and shoulder
42040	GP clinical event records	B326z00	Malignant melanoma of upper limb or shoulder NOS
42040	GP clinical event records	B327000	Malignant melanoma of hip
42040	GP clinical event records	B327100	Malignant melanoma of thigh
42040	GP clinical event records	B327200	Malignant melanoma of knee
42040	GP clinical event records	B327300	Malignant melanoma of popliteal fossa area
42040	GP clinical event records	B327400	Malignant melanoma of lower leg
42040	GP clinical event records	B327500	Malignant melanoma of ankle
42040	GP clinical event records	B327600	Malignant melanoma of heel
42040	GP clinical event records	B327700	Malignant melanoma of foot
42040	GP clinical event records	B327800	Malignant melanoma of toe
42040	GP clinical event records	B327900	Malignant melanoma of great toe
42040	GP clinical event records	B327.00	Malignant melanoma of lower limb and hip
42040	GP clinical event records	B327z00	Malignant melanoma of lower limb or hip NOS
42040	GP clinical event records	B32..00	Malignant melanoma of skin
42040	GP clinical event records	B32y000	Overlapping malignant melanoma of skin
42040	GP clinical event records	B32y.00	Malignant melanoma of other specified skin site
42040	GP clinical event records	B32z.00	Malignant melanoma of skin NOS
42040	GP clinical event records	BBE1000	[M]Malignant melanoma, regressing
42040	GP clinical event records	BBE1100	[M]Desmoplastic melanoma, malignant
42040	GP clinical event records	BBE1.00	[M]Malignant melanoma NOS
42040	GP clinical event records	BBE1.11	[M]Melanocarcinoma
42040	GP clinical event records	BBE1.12	[M]Melanoma NOS
42040	GP clinical event records	BBE1.13	[M]Melanosarcoma NOS
42040	GP clinical event records	BBE2.00	[M]Nodular melanoma
42040	GP clinical event records	BBE4.00	[M]Balloon cell melanoma
42040	GP clinical event records	BBEA.00	[M]Amelanotic melanoma
42040	GP clinical event records	BBEC.00	[M]Malignant melanoma in junctional naevus
42040	GP clinical event records	BBEF.00	[M]Hutchinson’s melanotic freckle
42040	GP clinical event records	BBEF.11	[M]Lentigo maligna
42040	GP clinical event records	BBEG000	[M]Acral lentiginous melanoma, malignant
42040	GP clinical event records	BBEG.00	[M]Malignant melanoma in Hutchinson’s melanotic freckle
42040	GP clinical event records	BBEG.11	[M]Lentigo maligna melanoma
42040	GP clinical event records	BBEH.00	[M]Superficial spreading melanoma
42040	GP clinical event records	BBEM.00	[M]Malignant melanoma in giant pigmented naevus
42040	GP clinical event records	BBEN.11	[M]Juvenila melanoma
42040	GP clinical event records	BBEP.00	[M]Epithelioid cell melanoma
42040	GP clinical event records	BBEQ.00	[M]Spindle cell melanoma NOS
42040	GP clinical event records	BBES.00	[M]Spindle cell melanoma, type B
42040	GP clinical event records	BBET.00	[M]Mixed epithelioid and spindle melanoma
42040	GP clinical event records	Byu4000	[X]Malignant melanoma of other+unspecified parts of face
42040	GP clinical event records	Byu4100	[X]Malignant melanoma of skin, unspecified
42040	GP clinical event records	XSNL7	Breslow depth staging for melanoma
42040	GP clinical event records	XSHw6	Clark melanoma level 3
42040	GP clinical event records	XSHw4	Clark melanoma level 1
42040	GP clinical event records	XSHw7	Clark melanoma level 4
42040	GP clinical event records	XaEGU	Malignant melanoma of chest wall
42040	GP clinical event records	XaCIv	Malignant melanoma of back
42040	GP clinical event records	XSHw8	Clark melanoma level 5
42040	GP clinical event records	XSHw5	Clark melanoma level 2
42040	GP clinical event records	XE1wX	[M]Malignant melanoma NOS
40006	Type of cancer: ICD10	C43	Malignant melanoma of skin