Metadata

Name Primary Malignancy of Mesothelioma (pri_mesothelioma)
Category Cancers
Sex
Adult Yes
UUID a2058d78-5505-497f-ab2d-a03ba68c3bc0
Definition Mesothelioma is a type of cancer that develops in the lining that covers the outer surface of some of the body’s organs.

Ontologies

Disease Ontology (DOID) DOID_1790
GWAS Catalogue EFO_0000770
MeSH D000086002
SNOMED-CT 62064005
FinnGen C3_MESOTHELIOMA

Key Summary Statistics

Cases from any source

Total 523
Female (%) 100 (19%)
Male (%) 423 (81%)

Year first recorded

pri_mesothelioma year of first event

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Cross-sourced pri_mesothelioma cases

Incidence & prevalence

Baseline prevalence stratified by sex

Female 0.0 (0.0,0.0)
Male 0.56 (0.01,1.11)

Incidence stratified by sex

Female 0.21 (0.09,0.33)
Male 1.3 (0.98,1.63)

Incidence stratified by age

Ages 40-44 0.0 (0.0,0.0)
Ages 45-49 0.07 (-0.07,0.22)
Ages 50-54 0.0 (0.0,0.0)
Ages 55-59 0.42 (0.13,0.7)
Ages 60-64 0.77 (0.43,1.1)
Ages 65-69 2.26 (1.6,2.92)

Period prevalence

Methods

Comparison with general population

Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)

CALIBER and UKB pri_mesothelioma prevalence comparison for multiple age groups

Population Ages 40-49 Ages 50-59 Ages 60-69
UK Biobank 0 (0,2) 1 (0,2) 7 (5,9)
CALIBER 7

Stratified by age and Townsend deprivation status

Deprivation status Ages 40-49 Ages 50-59 Ages 60-69
Least deprived 1(0,7) 2(0,6) 7(4,12)
Low 0(NaN,NaN) 0(NaN,NaN) 5(2,9)
Medium 0(NaN,NaN) 4(1,9) 8(5,14)
High 0(NaN,NaN) 0(NaN,NaN) 6(3,11)
Most deprived 1(0,5) 1(0,4) 8(4,14)

Stratified by age and country

Country Ages 40-49 Ages 50-59 Ages 60-69
England 0(0,2) 1(0,3) 7(5,9)
Scotland 0(NaN,NaN) 0(NaN,NaN) 6(2,13)
Wales 3(0,17) 2(0,12) 9(3,20)

Definition

UK Biobank field id Description Code Value
20001 Cancer code, self-reported 1064 mesothelioma
41202 Diagnoses - main ICD10 C45 Mesothelioma
41204 Diagnoses - secondary ICD10 C45 Mesothelioma
40001 Underlying (primary) cause of death: ICD10 C45 Mesothelioma
40002 Contributory (secondary) causes of death: ICD10 C45 Mesothelioma
42040 GP clinical event records BBP1.00 [M]Mesothelioma, malignant
42040 GP clinical event records BBP3.11 [M]Sarcomatoid mesothelioma
42040 GP clinical event records BBP5.00 [M]Epithelioid mesothelioma, malignant
42040 GP clinical event records BBP7.00 [M]Mesothelioma, biphasic type, malignant
40006 Type of cancer: ICD10 C45 Mesothelioma
22141 Doctor diagnosed mesothelioma of the lung 1 yes